Amol P. Kamboj
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View article: Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis
Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis Open
Psoriasis, an immune-mediated inflammatory disease, affects nearly 125 million people globally. The interleukin (IL)-17A homodimer is a key driver of psoriasis and other autoimmune diseases, including psoriatic arthritis, axial spondyloart…
View article: Do General Pathologists Assess Gastric and Duodenal Eosinophilia?
Do General Pathologists Assess Gastric and Duodenal Eosinophilia? Open
Context.— Eosinophilic diseases of the gastrointestinal tract (EGIDs), eosinophilic gastritis (EoG), and eosinophilic duodenitis (EoD) are rarely suspected clinically and infrequently detected by pathologists. Objective.— To determine whet…
View article: Mast cell activation is associated with post‐acute COVID‐19 syndrome
Mast cell activation is associated with post‐acute COVID‐19 syndrome Open
As of July 2021, over 30-million Americans have recovered from documented COVID-19 infection, and prevalence studies suggest up to twice as many may be undocumented.1 For the survivors of COVID-19, chronic morbidity is common, with reports…
View article: Diagnostic Delay in Patients with Eosinophilic Gastritis and/or Duodenitis: A Population-Based Study
Diagnostic Delay in Patients with Eosinophilic Gastritis and/or Duodenitis: A Population-Based Study Open
This study found that patients with EG/EoD experienced an average of 3.6 years between initial symptom presentation and diagnosis and revealed several factors contributing to diagnostic delay. We hope that these findings, together with hei…
View article: Anti–Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis
Anti–Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis Open
In patients with eosinophilic gastritis or duodenitis, AK002 reduced gastrointestinal eosinophils and symptoms. Infusion-related reactions were more common with AK002 than with placebo. (Funded by Allakos; ENIGMA ClinicalTrials.gov number,…
View article: Atopic Dermatitis Skin Biopsies Have High Numbers of Activated Mast Cells that Are Inhibited by AK002 after Stimulation Ex Vivo
Atopic Dermatitis Skin Biopsies Have High Numbers of Activated Mast Cells that Are Inhibited by AK002 after Stimulation Ex Vivo Open
View article: AK002, an Anti-Siglec-8 Antibody, Depletes Tissue Eosinophils and Improves Dysphagia Symptoms in Patients with Eosinophilic Esophagitis
AK002, an Anti-Siglec-8 Antibody, Depletes Tissue Eosinophils and Improves Dysphagia Symptoms in Patients with Eosinophilic Esophagitis Open
View article: A Longitudinal, Population-Based Study of the Difficult Journey to Diagnosis Endured by Patients with Eosinophilic Gastritis and Eosinophilic Gastroenteritis
A Longitudinal, Population-Based Study of the Difficult Journey to Diagnosis Endured by Patients with Eosinophilic Gastritis and Eosinophilic Gastroenteritis Open