Explanipedia

Consensus Statements for Clinical Practice in Advanced/Metastatic Colorectal Cancers in India Using a Modified Delphi Method Open

Anant Ramaswamy, Sujay Srinivas, Viraj Lavingia, Mounika Boppana, Chakor Vora , et al. · 2025

Colorectal cancer (CRC) is one of the most common malignancies across the world and is the fourth most common cancer among men in India as per the Global Cancer Observatory (GLOBOCAN) data 2020. Available data suggest that approximately 30…

Uniform Reporting of Next Generation Sequencing: Indian Society of Medical and Pediatric Oncology Open

Anu R I, Amol Patel, Neha Pathak, Prashant Mehta, Anuradha Choughule , et al. · 2025

Molecular oncology is the cornerstone for diagnosis, treatment, prognosis, and screening of individuals who present to an oncology clinic. The integration of molecular diagnostic techniques with therapeutic management of patients has resul…

Localized Rectal Cancer: Indian Consensus and Guidelines Open

Viraj Lavingia, Shefali Sardana, Mansi Khanderia, Niharika Bisht, Amol Patel , et al. · 2024

The rising incidence of colorectal cancer (CRC) in India, particularly the prevalence of rectal cancer over colon cancer (0.7:1), has been a growing concern in recent decades; especially notable is the trend of increasing cases among young…

Effectiveness of Immune Checkpoint Inhibitors in Various Tumor Types Treated by Low, Per-Weight, and Conventional Doses at a Tertiary Care Center in Mumbai Open

Amol Patel, Vivek Hande, Kaushik MR, Hemendra Dange, Amit Kumar Das , et al. · 2024

PURPOSE The cost of immune checkpoint inhibitors (ICIs) limits their accessibility to a small number of patients with cancer in low- and middle-income countries. Early-phase clinical trials have shown target inhibition and high activity at…

Factors Influencing the Risk of Involved and Close Squamous Cell Carcinoma Excision and Recurrence: A Comprehensive Analysis over a 7-Year Period Open

Mikesh Kalpesh Patel, M D Sreekumar, J. Manu-Gyamfi, Amol Patel · 2024

Background: This study collected data on patient management and outcomes following involved or close primary squamous cell carcinoma (SCC) excision, to determine what factors impacted the risk of involved or close excision and recurrence. …

A Survey on Unmet Need for Uniform Next-Generation Sequencing Reporting in India Open

Neha Pathak, Anu R I, Padmaj Kulkarni, Amol Patel · 2023

Introduction: Next-generation sequencing (NGS) has paved the way for precision oncology in oncology clinics today. With rapidly advancing therapeutics, it is becoming increasingly important to obtain information about the molecular milieu …

Phase 1/2 Study of the Timing and Efficacy of 3 mg Peg-GCSF in Neo/Adjuvant Dose Dense Breast Cancer Treatment Protocols Open

Amol Patel, Abhishek Pathak, Arti Sarin, Divya Shelly, Richa Ranjan , et al. · 2023

Background Peg-GCSF has similar efficacy at a dose of 60 µg/kg and 100 µg/kg. The conventional 6 mg SC dose was based on the maximum tolerable dose. In Japan, 3.6 mg dose was approved on the basis of dose finding studies. Peg-GCSF is an in…

Chewing Doma (Fermented Betel Nut): Culture versus Cancer? Open

Amol Patel, Manali I. Patel, Phub Tshering, Venkata Pradeep Babu Koyyala, Nikhil Ghadyalpatil · 2023

Areca nut consumption is embedded in many cultures, including that of Bhutan, several parts of India, and other South Eastern countries. Traditional fermenting of areca nut results in the production of what is called doma in Bhutan. The pr…

Molecular basis and clinical application of targeted therapy in oncology Open

TVSVGK Tilak, Amol Patel, Amul Kapoor · 2023

Cervical Cancer HPV Vaccination and Bhutan Open

Sachin Hingmire, Ugyen Tshomo, Tashi Dendrup, Amol Patel, Purvish M. Parikh · 2023

© 2023. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work…

Pharmacoeconomics Open

Amol Patel · 2022

With the rising cost of cancer care, there is a necessity felt to address this unique demanding situation. Unique in sense, desperation and hope are playing the main role for economic expenditure by the patients in diseases where outcomes …

Pembrolizumab Weight-Based Dosing: Conviction and Lacunae in Adopting a Cost-Saving Approach—A Survey Report Open

Amol Patel, Amol Akhade · 2022

Introduction Use of immunotherapy drugs has increased leaps and bounds in the last decade with promising results in some of the cancers. The use is limited in low- and middle-income countries due to cost constraints. Weight-based dosing is…

Letter to editor Open

M Parikh Purvish, Prashant Mehta, Amol Patel · 2022

The burden of cancer caregivers Open

KP Rohith, Amol Patel · 2022

Pembrolizumab weight based dosing – A call for policy change Open

Amol Patel, Amol Akhade, Purvish M. Parikh, Atul Sharma, Hemant Malhotra , et al. · 2022

Immuno-oncology (IO) drugs are now approved for use in metastatic, adjuvant, and/or neoadjuvant setting for a growing list of cancers including non-small cell lung cancer, small cell lung cancer, melanoma, urothelial cancer, renal cell car…

Cancer in the Adolescent and Young Adults (AYA) and Children: A Comprehensive Analysis of the Epidemiology and Psychosocial Morbidity in the Indian Population Open

Bhupesh Guleria, Sundaram Viswanath, Dharmesh Soneji, Rajan Kapoor, Prerna Guleria , et al. · 2021

Aims Adolescent and young adults (AYAs), children with cancer, and their guardians have unique psychosocial morbidities adversely effecting quality of life (QOL). This is measurable using patented tools. We analyzed epidemiological and cli…

ERBB and FGFR2 pathway inhibition in biliary tract cancers – Dawn of a new beginning Open

Amol Patel, Manoj Prashar · 2021

Pharmacoeconomics Open

Ian F. Tannock, Amol Patel · 2021

Advances in cancer treatment have led to substantial improvements in survival. These include several drugs for treatment of multiple myeloma and metastatic prostate cancer, and immunotherapy with checkpoint inhibitors for treatment of nons…

Reply to D. O'Reilly et al Open

Amol Patel, Vineet Govinda Gupta, Bivas Biswas, Sandip Ganguly, Chandan Krushna Das , et al. · 2021

Cancer trends and burden among Armed Forces personnel, veterans and their families: Cancer registry data analysis from tertiary care hospital Open

Amol Patel, R. Shankaran, Harinder Pal Singh, Shinjini Bhatnagar, Sharat Chandra Dash , et al. · 2021

Bathinda to Bikaner Open

Amol Patel · 2021

Revisiting Fulvestrant Dosing in Uncertain Economic Times Open

Amol Patel, Vineet Govinda Gupta, Bivas Biswas, Chandan Krushna Das, Atul Batra , et al. · 2021

Indian Council of Medical Research consensus document on hepatocellular carcinoma Open

Bhawna Sirohi, ShaileshV Shrikhande, Vinay Gaikwad, Amol Patel, Shraddha Patkar , et al. · 2020

This document aims to assist oncologists in making clinical decisions encountered while managing their patients with hepatocellular carcinoma (HCC), specific to Indian practice, based on consensus among experts. Most patients are staged by…

How We Treat Genitourinary Cancers During COVID-19 Pandemic? Open

Deepak Dabkara, Sandip Ganguly, Joydeep Ghosh, Amol Patel, Atul Batra , et al. · 2020

Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome - coronavirus 2 (SARS-CoV-2) has become a pandemic and affected the entire globe. Daily routine life is affected due to global restriction of movement and infected …

Genomic Landscape and Targeted Treatment of Gallbladder Cancer: Results of a First Ongoing Prospective Study Open

Amol Patel, Dharmesh Soneji, Harinder Pal Singh, Manish Kumar, Arnab Bandyopadhyay , et al. · 2020

Background Prognosis of gallbladder cancer (GBC) has not changed in the past 20 years. Comprehensive genomic profiling (CGP) carries potential to determine the actionability for multiple targets, including ERBB2, ERBB3, MET, ROSI, FGFR, an…

Discordance between Fluorescence In Situ Hybridization and Immunohistochemistry Analysis of Anaplastic Lymphoma Kinase Rearrangement in Indian Patients with Non-Small Cell Lung Cancer Open

Manish Kumar, Kishore Kumar, Harinder Pal Singh, Suresh Nair, Amol Patel , et al. · 2020

Aims This study aims to evaluate the incidence of anaplastic lymphoma kinase (ALK) mutation in nonsmall cell lung cancer (NSCLC) incorporating fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) methods and to look for…

Protecting health-care professionals and workers (other than COVID-19 management facilities) from contamination during COVID-19 pandemic (March 26, 2020 – India) Open

Purvish M. Parikh, Prashant Mehta, Shweta Bansal, Shyam Aggarwal, Amol Patel , et al. · 2020

Low-Dose Abiraterone in Metastatic Prostate Cancer: Is It Practice Changing? Facts and Facets Open

Amol Patel, Ian F. Tannock, Priyanka Srivastava, Bivas Biswas, Vineet Govinda Gupta , et al. · 2020

PURPOSE It is projected that approximately 50,000 new cases of prostate cancer will be diagnosed in 2020 in India. Survival has improved because of the development of effective drugs such as abiraterone acetate, but universal accessibility…

Colorectal Cancer Chemotherapy during COVID-19 Pandemic Open

Sainath Bhethanabhotla, Raja Pramanik, Priyanka Srivastava, Prashant Mehta, Amol Patel , et al. · 2020

The management of patients with colorectal cancer during the current SARS-CoV2 pandemic opens a Pandora's Box. While the world is facing an unprecedented crisis of fighting a life-threatening infectious disease, patients with colorectal ca…

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