Amr R. Ghanam
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View article: PROLONGED FEVER DUE TO ACUTE PNEUMONIA REVEALING ATRABRONCHIAL FOREIGN BODY IN A 5-YEAR-OLD CHILD
PROLONGED FEVER DUE TO ACUTE PNEUMONIA REVEALING ATRABRONCHIAL FOREIGN BODY IN A 5-YEAR-OLD CHILD Open
Incidents involving intratracheobronchial foreign bodies (ITFBs) are common in children and can lead to serious long-term complications such as bronchiectasis. Typically, these incidents present with a penetration syndrome following the in…
View article: LOCALIZED JUVENILE SCLERODERMA IN ITS LINEAR FORM: A CASE STUDY
LOCALIZED JUVENILE SCLERODERMA IN ITS LINEAR FORM: A CASE STUDY Open
Localized juvenile scleroderma is an autoimmune disease with an unknown cause, marked by skin fibrosis and sometimes involving the underlying fascia, muscles, and skeletal tissue. The diseases severity can vary from isolated skin hardening…
View article: PREVALENCE OF EATING DISORDERS IN A PEDIATRIC POPULATION IN THE EASTERN REGION OF MOROCCO
PREVALENCE OF EATING DISORDERS IN A PEDIATRIC POPULATION IN THE EASTERN REGION OF MOROCCO Open
Biopsychosocial diseases, particularly eating disorders (EDs), are increasingly prevalent and involve different body systems and individual aspects as well as their social relationships. This study aims at finding out the extent to which e…
View article: DISCOVERY OF DYSKERATOSISCONGENITA BY APLASTICHEMORRHAGE: A REVEALINGCLINICAL CASE
DISCOVERY OF DYSKERATOSISCONGENITA BY APLASTICHEMORRHAGE: A REVEALINGCLINICAL CASE Open
Dyskeratosiscongenita (DC) is a rare geneticdisordercharacterized by a distinctive clinicaltriadaffecting the skin, mucous membranes and bonemarrow. Although the condition has been described for over a century, itoftenremainsunrecognized a…
View article: PROFILE OF ISCHEMIC STROKE IN CHILDREN: EXPERIENCE OF THE UNIVERSITY HOSPITAL CENTER OF OUJDA
PROFILE OF ISCHEMIC STROKE IN CHILDREN: EXPERIENCE OF THE UNIVERSITY HOSPITAL CENTER OF OUJDA Open
Ischemic strokes (IS) in children are rare but critical, presenting unique challenges due to age-specific factors. Defined by the American Heart Association as episodes of neurological dysfunction caused by focal infarctions, IS can lead t…
View article: Author Correction: Generation and comparative analysis of an Itga8-CreERT2 mouse with preferential activity in vascular smooth muscle cells
Author Correction: Generation and comparative analysis of an Itga8-CreERT2 mouse with preferential activity in vascular smooth muscle cells Open
View article: Supplementary Material for: Triple-A syndrome in Morocco: founder effect, age estimation of the AAAS c.1331+1G>A variant and implications for genetic diagnosis
Supplementary Material for: Triple-A syndrome in Morocco: founder effect, age estimation of the AAAS c.1331+1G>A variant and implications for genetic diagnosis Open
Introduction: Triple-A syndrome (Triple-A) is an autosomal recessive disorder characterized by alacrimia, achalasia and adrenal insufficiency. Several variants on the AAAS gene have been described, and some variants are clustered in partic…
View article: Prime Editing in Mice with an Engineered pegRNA
Prime Editing in Mice with an Engineered pegRNA Open
View article: Alternative transcribed 3' isoform of long non-coding RNA Malat1 inhibits mouse retinal oxidative stress
Alternative transcribed 3' isoform of long non-coding RNA Malat1 inhibits mouse retinal oxidative stress Open
View article: Generation and comparative analysis of an Itga8-CreERT2 mouse with preferential activity in vascular smooth muscle cells
Generation and comparative analysis of an Itga8-CreERT2 mouse with preferential activity in vascular smooth muscle cells Open
View article: In Silico Study and Excito-Repellent Activity of Vitex negundo L. Essential Oil against Anopheles gambiae
In Silico Study and Excito-Repellent Activity of Vitex negundo L. Essential Oil against Anopheles gambiae Open
(1) Background: Essential oil from Vitex negundo is known to have repellent and insecticidal properties toward the Anopheles gambiae and this is linked to its monoterpene and sesquiterpene content. In this work, an effort is made to deline…
View article: An Inducible <i>Cre</i> Mouse with Preferential Activity in Vascular Smooth Muscle Evades a Previously Lethal Intestinal Phenotype
An Inducible <i>Cre</i> Mouse with Preferential Activity in Vascular Smooth Muscle Evades a Previously Lethal Intestinal Phenotype Open
All smooth muscle cell (SMC) restricted Cre mice recombine floxed alleles in vascular and visceral SMCs. We generated a new tamoxifen-inducible CreER T2 mouse, Itga8-CreER T2 , and compared its activity to the widely used Myh11-CreER T2 mo…
View article: Of mice and human-specific long noncoding RNAs
Of mice and human-specific long noncoding RNAs Open
View article: Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression
Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression Open
Background Most single nucleotide variants (SNVs) occur in noncoding sequence where millions of transcription factor binding sites (TFBS) reside. Here, a comparative analysis of CRISPR-mediated homology-directed repair (HDR) versus the rec…
View article: Additional file 8 of Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression
Additional file 8 of Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression Open
Additional file 8. Supplementary Table S7. List of primers.
View article: Additional file 3 of Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression
Additional file 3 of Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression Open
Additional file 3. Supplementary Table S2. Dseq of bulk RNA-seq.
View article: Additional file 5 of Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression
Additional file 5 of Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression Open
Additional file 5. Supplementary Table S4. Pool 2 off-targets.
View article: Additional file 7 of Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression
Additional file 7 of Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression Open
Additional file 7. Supplementary Table S6. pegRNA off-targets and CArG boxes.
View article: Additional file 6 of Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression
Additional file 6 of Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression Open
Additional file 6. Supplementary Table S5. sgRNA off-targets and CArG boxes.
View article: Additional file 2 of Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression
Additional file 2 of Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression Open
Additional file 2. Supplementary Table S1. CRISPR targets.
View article: Additional file 4 of Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression
Additional file 4 of Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression Open
Additional file 4. Supplementary Table S3. Pool 1 off-targets.
View article: Prime Editing in Mice Reveals the Essentiality of a Single Base in Driving Tissue-Specific Gene Expression
Prime Editing in Mice Reveals the Essentiality of a Single Base in Driving Tissue-Specific Gene Expression Open
Most single nucleotide variants (SNVs) occur in noncoding sequence where millions of transcription factor binding sites (TFBS) reside. Several genome editing platforms have emerged to evaluate the functionality of TFBS in animals. Here, a …
View article: The aortic root in repaired tetralogy of Fallot: Serial measurements and impact of losartan treatment
The aortic root in repaired tetralogy of Fallot: Serial measurements and impact of losartan treatment Open
View article: New Insights into Chronological Mobility of Retrotransposons In Vivo
New Insights into Chronological Mobility of Retrotransposons In Vivo Open
Tissue aging is the gradual decline of physiological homeostasis accompanied with accumulation of senescent cells, decreased clearance of unwanted biological compounds, and depletion of stem cells. Senescent cells were cell cycle arrested …
View article: Correction to: The key role of CYC2 during meiosis in Tetrahymena Thermophila
Correction to: The key role of CYC2 during meiosis in Tetrahymena Thermophila Open
In the original publication, the funding information was incorrectly published. The correct funding information is provided in this correction. This work is supported by grants from the Projects of International Cooperation and Exchanges M…
View article: Shining the Light on Senescence Associated LncRNAs
Shining the Light on Senescence Associated LncRNAs Open
Cellular senescence can be described as a complex stress response that leads to irreversible cell cycle arrest. This process was originally described as an event that primary cells go through after many passages of cells during cell cultur…
View article: The key role of CYC2 during meiosis in Tetrahymena thermophila
The key role of CYC2 during meiosis in Tetrahymena thermophila Open
Meiotic recombination is carried out through a specialized pathway for the formation and repair of DNA double-strand breaks (DSBs) made by the Spo11 protein. The present study shed light on the functional role of cyclin, CYC2, in Tetrahyme…