Amitinder Kaur
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View article: A rhesus macaque model of congenital cytomegalovirus infection reveals a spectrum of vertical transmission outcomes
A rhesus macaque model of congenital cytomegalovirus infection reveals a spectrum of vertical transmission outcomes Open
Congenital cytomegalovirus (cCMV) is the leading infectious cause of birth defects worldwide, yet immune determinants of protection to inform maternal vaccine design remain elusive due to the lack of a translational animal model. Here, we …
View article: Neutrophils at the Maternal‐Fetal Interface: Agents of Protection or Destruction?
Neutrophils at the Maternal‐Fetal Interface: Agents of Protection or Destruction? Open
Neutrophils, traditionally recognized for their role in innate immunity, have emerged as a key cell population at the maternal‐fetal interface, during both uncomplicated and pathological pregnancies. Neutrophil effector functions, includin…
View article: Inflammatory neutrophil responses and T cell activation in ART-treated SIVmac239-infected rhesus macaques
Inflammatory neutrophil responses and T cell activation in ART-treated SIVmac239-infected rhesus macaques Open
Modern antiretroviral therapy (ART) regimens have revolutionized the management of human immunodeficiency virus (HIV) and transformed it from a life-threatening disease to a manageable chronic condition. Despite the durable viral suppressi…
View article: Persistence of CMV-specific anti-HIV CAR T cells after adoptive immunotherapy
Persistence of CMV-specific anti-HIV CAR T cells after adoptive immunotherapy Open
The success of chimeric antigen receptor (CAR)-T cell (Tc) immunotherapy in refractory B-cell acute lymphoblastic leukemia (B-ALL) suggests adaptation of this strategy toward HIV. Because cytomegalovirus (CMV) vaccine vectors generated Tc …
View article: The pentameric complex is not required for congenital CMV transmission in seronegative rhesus macaques
The pentameric complex is not required for congenital CMV transmission in seronegative rhesus macaques Open
Congenital cytomegalovirus (cCMV) is the leading infectious cause of neonatal neurological impairment worldwide, but the viral factors enabling vertical spread across the placenta remain undetermined. The pentameric complex (PC), composed …
View article: Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity
Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity Open
Human cytomegalovirus (HCMV) encodes four viral Fc-gamma receptors (vFcγRs) that counteract antibody-mediated activation in vitro, but their role in infection and pathogenesis is unknown. To examine their in vivo function in an animal mode…
View article: A nonhuman primate model mirrors human congenital cytomegalovirus infection and reveals a spectrum of vertical transmission outcomes
A nonhuman primate model mirrors human congenital cytomegalovirus infection and reveals a spectrum of vertical transmission outcomes Open
Congenital cytomegalovirus (cCMV) is the leading infectious cause of birth defects worldwide, yet immune determinants of protection to inform design of a maternal vaccine remain elusive. Here, we characterized the outcome of primary rhesus…
View article: RhCMV Expands CCR5 Memory T Cells and promotes SIV reservoir genesis in the Gut Mucosa
RhCMV Expands CCR5 Memory T Cells and promotes SIV reservoir genesis in the Gut Mucosa Open
Cytomegalovirus (CMV) is a prevalent β-herpesvirus that persists asymptomatically in immunocompetent hosts. In people with HIV-1 (PWH), CMV is associated with persistence of the HIV-1 reservoir and particular inflammatory related co-morbid…
View article: Comparative analysis of rhesus macaque and human placental organoids highlights evolutionary differences in placentation
Comparative analysis of rhesus macaque and human placental organoids highlights evolutionary differences in placentation Open
Throughout evolution, the placenta has diversified in structure and cellular composition while maintaining its essential role in supporting fetal development. Trophoblasts, key cells responsible for nutrient exchange and immune modulation,…
View article: Extracellular domain, hinge, and transmembrane determinants affecting surface CD4 expression of a novel anti-HIV chimeric antigen receptor (CAR) construct
Extracellular domain, hinge, and transmembrane determinants affecting surface CD4 expression of a novel anti-HIV chimeric antigen receptor (CAR) construct Open
Chimeric antigen receptor (CAR)-T cells have demonstrated clinical potential, but current receptors still need improvements to be successful against chronic HIV infection. In this study, we address some requirements of CAR motifs for stron…
View article: Elevated Inflammation Associated with Markers of Neutrophil Function and Gastrointestinal Disruption in Pilot Study of Plasmodium fragile Co-Infection of ART-Treated SIVmac239+ Rhesus Macaques
Elevated Inflammation Associated with Markers of Neutrophil Function and Gastrointestinal Disruption in Pilot Study of Plasmodium fragile Co-Infection of ART-Treated SIVmac239+ Rhesus Macaques Open
Human immunodeficiency virus (HIV) and malaria, caused by infection with Plasmodium spp., are endemic in similar geographical locations. As a result, there is high potential for HIV/Plasmodium co-infection, which increases the pathology of…
View article: Co-Infection of ART-treated SIVmac239+ Rhesus Macaques with Plasmodium fragile Results in Elevated Inflammation which Associates with Neutrophil Function
Co-Infection of ART-treated SIVmac239+ Rhesus Macaques with Plasmodium fragile Results in Elevated Inflammation which Associates with Neutrophil Function Open
Human immunodeficiency virus (HIV) and malaria, caused by infection with Plasmodium spp., are endemic in similar geographical locations. As a result, there is high potential for HIV/Plasmodium co-infection, which increases the pathology of…
View article: Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity
Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity Open
Human cytomegalovirus (HCMV) encodes four viral Fc-gamma receptors (vFcγRs) that counteract antibody-mediated activation in vitro , but their role in infection and pathogenesis is unknown. To examine the in vivo function of vFcγRs in anima…
View article: Exploring HIV Vaccine Progress in the Pre-Clinical and Clinical Setting: From History to Future Prospects
Exploring HIV Vaccine Progress in the Pre-Clinical and Clinical Setting: From History to Future Prospects Open
The human immunodeficiency virus (HIV) continues to pose a significant global health challenge, with millions of people affected and new cases emerging each year. While various treatment and prevention methods exist, including antiretrovir…
View article: Exploring HIV Vaccine Progress in Pre-clinical and Clinical Settings: From History to Future Prospects.
Exploring HIV Vaccine Progress in Pre-clinical and Clinical Settings: From History to Future Prospects. Open
The human immunodeficiency virus (HIV) continues to pose a significant global health challenge, with millions of people affected and new cases emerging each year. While various treatment and prevention methods exist, including antiretrovir…
View article: Extracellular domain, hinge, and transmembrane determinants affecting surface CD4 expression of a novel anti-HIV chimeric antigen receptor (CAR) construct
Extracellular domain, hinge, and transmembrane determinants affecting surface CD4 expression of a novel anti-HIV chimeric antigen receptor (CAR) construct Open
Chimeric antigen receptor (CAR)-T cells have demonstrated clinical potential, but current receptors still need improvements to be successful against chronic HIV infection. In this study, we address some requirements of CAR motifs for stron…
View article: Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model
Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model Open
Cytomegalovirus (CMV) is the most common congenital infection and cause of birth defects worldwide. Primary CMV infection during pregnancy leads to a higher frequency of congenital CMV (cCMV) than maternal re-infection, suggesting that mat…
View article: Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection
Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection Open
Congenital cytomegalovirus (cCMV) is the leading infectious cause of neurologic defects in newborns with particularly severe sequelae in the setting of primary CMV infection in the first trimester of pregnancy. The majority of cCMV cases w…
View article: Mathematical Modeling of Rhesus Cytomegalovirus Transplacental Transmission in Seronegative Rhesus Macaques
Mathematical Modeling of Rhesus Cytomegalovirus Transplacental Transmission in Seronegative Rhesus Macaques Open
Approximately 0.7% of infants are born with congenital cytomegalovirus (CMV), making it the most common congenital infection. About 1 in 5 congenitally infected babies will suffer long-term sequelae, including sensorineural deafness, intel…
View article: Role of immunometabolism during congenital cytomegalovirus infection
Role of immunometabolism during congenital cytomegalovirus infection Open
Cytomegalovirus (CMV) is a master manipulator of host metabolic pathways. The impact of CMV metabolic rewiring during congenital CMV on immune function is unknown. CMV infection can directly alter glycolytic and oxidative phosphorylation p…
View article: Comparison of fine‐needle aspiration techniques
Comparison of fine‐needle aspiration techniques Open
Background Fine‐needle aspiration (FNA) has been reported since 1912 beginning with the use of trocars and other specialized instruments that were impractical. Since then, FNA has proven to be a successful alternative technique to excision…
View article: The pentameric complex is not required for vertical transmission of cytomegalovirus in seronegative pregnant rhesus macaques
The pentameric complex is not required for vertical transmission of cytomegalovirus in seronegative pregnant rhesus macaques Open
Congenital cytomegalovirus (cCMV) infection is the leading infectious cause of neonatal neurological impairment but essential virological determinants of transplacental CMV transmission remain unclear. The pentameric complex (PC), composed…
View article: Rhesus macaque cytomegalovirus deploys viral Fcγ receptors to evade antibody-mediated cellular immunity
Rhesus macaque cytomegalovirus deploys viral Fcγ receptors to evade antibody-mediated cellular immunity Open
Cytomegalovirus (CMV) is a top priority in vaccine development due to the high burden of disease in immunocompromised populations and congenitally infected infants. Evidence suggests that CMV-specific Fc-mediated antibody effector response…
View article: Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model
Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model Open
Cytomegalovirus (CMV) is the most common congenital infection and cause of birth defects worldwide. Primary CMV infection during pregnancy leads to a higher frequency of congenital CMV (cCMV) than maternal re-infection, suggesting that mat…
View article: Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection
Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection Open
Congenital cytomegalovirus (cCMV) is the leading infectious cause of neurologic defects in newborns with particularly severe sequelae in the setting of primary CMV infection in the first trimester of pregnancy. The majority of cCMV cases w…
View article: Derisking Human Cytomegalovirus Vaccine Clinical Development in Relevant Preclinical Models
Derisking Human Cytomegalovirus Vaccine Clinical Development in Relevant Preclinical Models Open
(See the major article by Li et al, on pages XX–XX.) The field of vaccinology will be forever changed by the breath-takingly rapid speed of development of safe and effective vaccines for severe acute respiratory syndrome-coronavirus-2 (SAR…