Amresh Raina
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View article: Dosing patterns and dose effects of sacubitril/valsartan: A claims-based retrospective cohort study
Dosing patterns and dose effects of sacubitril/valsartan: A claims-based retrospective cohort study Open
Purpose The goals of this retrospective cohort analysis were to determine real-world dose and titration patterns of sacubitril/valsartan (SAC/VAL), a heart failure medication, and examine whether dose patterns are associated with healthcar…
View article: Congruency between clinician‐assessed risk and calculated risk of 1‐year mortality in patients with pulmonary arterial hypertension: A retrospective chart review
Congruency between clinician‐assessed risk and calculated risk of 1‐year mortality in patients with pulmonary arterial hypertension: A retrospective chart review Open
The objective of this analysis was to compare clinician‐based and formally calculated risk assessments by REVEAL Lite 2 and COMPERA 2.0 and to characterize parenteral prostacyclin utilization within 90 days of baseline in high‐risk patient…
View article: Transplanted Heart Complicated by Intracardiac Aspergilloma With Pericardial Involvement
Transplanted Heart Complicated by Intracardiac Aspergilloma With Pericardial Involvement Open
A cardiac transplant recipient initially presented with right eye pain and blurry vision. After extensive workup, she was diagnosed with intracardiac aspergilloma with pericardial involvement complicated by endogenous endophthalmitis and a…
View article: Inhaled treprostinil in pulmonary hypertension associated with COPD: PERFECT study results
Inhaled treprostinil in pulmonary hypertension associated with COPD: PERFECT study results Open
Background Pulmonary hypertension (PH) accompanying COPD (PH-COPD) is associated with worse outcomes than COPD alone. There are currently no approved therapies to treat PH-COPD. The PERFECT study ( ClinicalTrials.gov : NCT03496623 ) evalua…
View article: Survival analysis from the INCREASE study in PH-ILD: evaluating the impact of treatment crossover on overall mortality
Survival analysis from the INCREASE study in PH-ILD: evaluating the impact of treatment crossover on overall mortality Open
Objective A post-hoc analysis of the INCREASE trial and its open-label extension (OLE) was performed to evaluate whether inhaled treprostinil has a long-term survival benefit in patients with pulmonary hypertension associated with intersti…
View article: Rapidly progressive pulmonary hypertension and right ventricular failure in a heart and kidney transplant recipient
Rapidly progressive pulmonary hypertension and right ventricular failure in a heart and kidney transplant recipient Open
A 54‐year‐old man status post heart and kidney transplant presented with dyspnea. Imaging was consistent with lymphangitic carcinomatosis (LC), in the setting of biopsy proven adenocarcinoma. He developed pulmonary hypertension (PH) and di…
View article: Change in REVEAL Lite 2 and COMPERA 2.0 risk status in patients with pulmonary arterial hypertension initiating oral treprostinil on dual background therapy: a retrospective chart review
Change in REVEAL Lite 2 and COMPERA 2.0 risk status in patients with pulmonary arterial hypertension initiating oral treprostinil on dual background therapy: a retrospective chart review Open
Background Post-hoc analyses of the FREEDOM-EV study demonstrated that addition of oral treprostinil (ORE) to background monotherapy improves risk in patients with pulmonary arterial hypertension (PAH). Evidence is needed to understand the…
View article: Mortality in Pulmonary Arterial Hypertension in the Modern Era: Early Insights From the Pulmonary Hypertension Association Registry
Mortality in Pulmonary Arterial Hypertension in the Modern Era: Early Insights From the Pulmonary Hypertension Association Registry Open
Background Current mortality data for pulmonary arterial hypertension (PAH) in the United States are based on registries that enrolled patients prior to 2010. We sought to determine mortality in PAH in the modern era using the PHAR (Pulmon…
View article: Incidence of Post-Heart Transplant Chronic Thyroiditis and Its Association With Pretransplant Amiodarone Use
Incidence of Post-Heart Transplant Chronic Thyroiditis and Its Association With Pretransplant Amiodarone Use Open
The incidence of post-HT CT is high and is strongly associated with pre-HT amiodarone use underpinning the importance of closely following the post-HT thyroid profile in these patients.
View article: Reasons for refusing parenteral therapy: a qualitative study of patients with pulmonary arterial hypertension
Reasons for refusing parenteral therapy: a qualitative study of patients with pulmonary arterial hypertension Open
While parenteral prostacyclin (pPCY) therapy, delivered either subcutaneously or intravenously, is recommended for pulmonary arterial hypertension patients with severe or rapidly developing disease, some patients refuse this treatment. Thi…
View article: Transition from parenteral prostacyclins to selexipag: safety and feasibility in selected patients
Transition from parenteral prostacyclins to selexipag: safety and feasibility in selected patients Open
There are limited data regarding the feasibility of transitioning from intravenous prostacyclins to selexipag in pulmonary arterial hypertension patients. We present a case series of successful transitions from intravenous prostacyclins to…
View article: Outcomes of patients hospitalized for acute pulmonary embolism by obstructive sleep apnea status
Outcomes of patients hospitalized for acute pulmonary embolism by obstructive sleep apnea status Open
Pulmonary embolism (PE) is a major cause of cardiovascular morbidity and mortality. Obstructive sleep apnea (OSA) is increasingly recognized in the aging population, especially with the rising obesity epidemic. The impact of OSA on inpatie…
View article: Data on clinical and economic burden associated with pulmonary arterial hypertension related hospitalizations in the United States
Data on clinical and economic burden associated with pulmonary arterial hypertension related hospitalizations in the United States Open
A comprehensive description of the contemporary trends in pulmonary arterial hypertension (PAH) related hospitalizations, associated inpatient outcomes and predictors of worse outcomes were reported in our paper recently published in the I…
View article: Safety and efficacy of transitioning from the combination of bosentan and sildenafil to alternative therapy in patients with pulmonary arterial hypertension
Safety and efficacy of transitioning from the combination of bosentan and sildenafil to alternative therapy in patients with pulmonary arterial hypertension Open
The combination of bosentan and sildenafil is commonly used to treat patients with pulmonary arterial hypertension (PAH); however, there is evidence of a significant drug interaction between these two medications. We sought to evaluate the…
View article: Quantification of Cardiac Output with Phase Contrast Magnetic Resonance Imaging in Patients with Pulmonary Hypertension
Quantification of Cardiac Output with Phase Contrast Magnetic Resonance Imaging in Patients with Pulmonary Hypertension Open
Objective: The purpose of the study is to compare phase contrast (PC) imaging with invasive measurements of cardiac output (CO) in patients with pulmonary hypertension (PH). Materials and Methods: We analyzed 81 cases with PH who underwent…
View article: <p>Understanding the early mortality benefit observed in the PARADIGM-HF trial: considerations for the management of heart failure with sacubitril/valsartan</p>
Understanding the early mortality benefit observed in the PARADIGM-HF trial: considerations for the management of heart failure with sacubitril/valsartan Open
This review aims to elucidate the optimal dosing of angiotensin receptor-neprilysin inhibitor (ARNI) therapy in the heart failure (HF) treatment paradigm through examination of the trial population characteristics and the mortality benefit…
View article: Sex-Based Differences in Left Ventricular Assist Device Utilization
Sex-Based Differences in Left Ventricular Assist Device Utilization Open
Background: Women comprise approximately one-third of the advanced heart failure population but may receive fewer advanced heart failure therapies including left ventricular assist devices (LVADs). During the early pulsatile-flow device er…
View article: Malpositioned endocardial left ventricular pacing lead extraction with transcatheter cerebral embolic protection in the setting of multiple prior embolic strokes
Malpositioned endocardial left ventricular pacing lead extraction with transcatheter cerebral embolic protection in the setting of multiple prior embolic strokes Open
Pacing lead malposition in the left ventricle increases risk of embolic stroke. We present a case of malpositioned left ventricular (LV) lead extraction using transcatheter cerebral embolic protection (TCEP) for procedure-related stroke pr…