Amrish Sharma
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View article: Supplementary Figures S1-S9 from Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non–Small Cell Lung Cancer
Supplementary Figures S1-S9 from Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non–Small Cell Lung Cancer Open
Supplementary Figures
View article: Data from Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non–Small Cell Lung Cancer
Data from Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non–Small Cell Lung Cancer Open
Purpose: The MEK inhibitor trametinib radiosensitizes KRAS-mutant non–small cell lung cancer (NSCLC) and is being tested clinically with chemoradiation. However, variability in response to trametinib suggests that additional pathway…
View article: Supplementary figure legends from Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non–Small Cell Lung Cancer
Supplementary figure legends from Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non–Small Cell Lung Cancer Open
Supplementary figure legends
View article: Supplementary Figures S1-S9 from Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non–Small Cell Lung Cancer
Supplementary Figures S1-S9 from Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non–Small Cell Lung Cancer Open
Supplementary Figures
View article: Supplementary figure legends from Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non–Small Cell Lung Cancer
Supplementary figure legends from Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non–Small Cell Lung Cancer Open
Supplementary figure legends
View article: Data from Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non–Small Cell Lung Cancer
Data from Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non–Small Cell Lung Cancer Open
Purpose: The MEK inhibitor trametinib radiosensitizes KRAS-mutant non–small cell lung cancer (NSCLC) and is being tested clinically with chemoradiation. However, variability in response to trametinib suggests that additional pathway…
View article: Supplementary Table S1 from Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non–Small Cell Lung Cancer
Supplementary Table S1 from Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non–Small Cell Lung Cancer Open
Oligos for pLentiCRISPRv2 construction
View article: Supplementary Table S1 from Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non–Small Cell Lung Cancer
Supplementary Table S1 from Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non–Small Cell Lung Cancer Open
Oligos for pLentiCRISPRv2 construction
View article: Supplementary Figure 1 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Figure 1 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 155KB, UTX knockdown had no effect on cell migration, whereas MLL4 depletion moderately decreased cell migration.
View article: Supplementary Figure 6 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Figure 6 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 57KB, MLL4 Knockdown decreased UTX mRNA and protein levels, but UTX knockdown did not have any significant effect on MLL4 mRNA levels.
View article: Supplementary Figure and Table Legends from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Figure and Table Legends from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 102KB
View article: Supplementary Table 1 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Table 1 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 22KB, Primer and shRNA sequences.
View article: Supplementary Figure 5 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Figure 5 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 33KB, UTX or MLL4 knockdown did not have any obvious effect on total cellular levels of H3K27me3 and H3K4me3.
View article: Supplementary Table 2 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Table 2 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 61KB, Statistically significant Gene Ontology (GO) terms of genes co- downregulated by UTX and MLL4 knockdown.
View article: Data from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Data from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
Histone methyltransferases and demethylases reversibly modulate histone lysine methylation, which is considered a key epigenetic mark associated with gene regulation. Recently, aberrant regulation of gene expression by histone methylation …
View article: Supplementary Figure 2 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Figure 2 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 33KB, UTX or MLL4 knockdown reduced expression levels of MMP-9, MMP-11, Six1, Cyclin A1, and CSPG4 genes in MDA-MB-468 cells.
View article: Supplementary Figure and Table Legends from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Figure and Table Legends from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 102KB
View article: Supplementary Figure 1 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Figure 1 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 155KB, UTX knockdown had no effect on cell migration, whereas MLL4 depletion moderately decreased cell migration.
View article: Supplementary Figure 5 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Figure 5 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 33KB, UTX or MLL4 knockdown did not have any obvious effect on total cellular levels of H3K27me3 and H3K4me3.
View article: Supplementary Figure 3 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Figure 3 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 21KB, UTX depletion did not affect the expression of Rb gene and other Rb pathway genes.
View article: Supplementary Figure 4 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Figure 4 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 48KB, Two different MLL4 antibodies confirmed that MLL4 is recruited to MMP-9, MMP-11, and Six1 genes.
View article: Supplementary Table 1 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Table 1 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 22KB, Primer and shRNA sequences.
View article: Supplementary Table 2 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Table 2 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 61KB, Statistically significant Gene Ontology (GO) terms of genes co- downregulated by UTX and MLL4 knockdown.
View article: Supplementary Figure 6 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Figure 6 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 57KB, MLL4 Knockdown decreased UTX mRNA and protein levels, but UTX knockdown did not have any significant effect on MLL4 mRNA levels.
View article: Supplementary Figure 4 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Figure 4 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 48KB, Two different MLL4 antibodies confirmed that MLL4 is recruited to MMP-9, MMP-11, and Six1 genes.
View article: Supplementary Figure 3 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Figure 3 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 21KB, UTX depletion did not affect the expression of Rb gene and other Rb pathway genes.
View article: Supplementary Figure 2 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Supplementary Figure 2 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
PDF file - 33KB, UTX or MLL4 knockdown reduced expression levels of MMP-9, MMP-11, Six1, Cyclin A1, and CSPG4 genes in MDA-MB-468 cells.
View article: Data from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Data from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells Open
Histone methyltransferases and demethylases reversibly modulate histone lysine methylation, which is considered a key epigenetic mark associated with gene regulation. Recently, aberrant regulation of gene expression by histone methylation …
View article: A Systematic Review and Meta-analysis of the Impact of Radiation-Related Lymphopenia on Outcomes in High-Grade Gliomas
A Systematic Review and Meta-analysis of the Impact of Radiation-Related Lymphopenia on Outcomes in High-Grade Gliomas Open
Introduction Malignant gliomas are the most common primary malignant brain tumors and are typically treated with maximal safe surgical resection followed by chemoradiation. One of the unintended effects of radiation is depletion of circula…
View article: A Systematic Review of Radiation-Related Lymphopenia in Genito-urinary Malignancies
A Systematic Review of Radiation-Related Lymphopenia in Genito-urinary Malignancies Open
The impact of radiation-related lymphopenia on clinical outcomes has been reported in various solid malignancies such as high grade gliomas, head and neck cancers, thoracic malignancies and gastro-intestinal malignancies but its impact is …