Amrit Ramesh
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View article: Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection
Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection Open
View article: Hyaluronan Synthesis Inhibition Impairs Antigen Presentation and Delays Transplantation Rejection
Hyaluronan Synthesis Inhibition Impairs Antigen Presentation and Delays Transplantation Rejection Open
A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation. We find…
View article: Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation
Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation Open
Metabolic reprogramming is considered important in the pathogenesis of the occlusive vasculopathy observed in pulmonary hypertension (PH). However, the mechanisms that link reprogrammed metabolism to aberrant expression of genes, which mod…