Amrita Bhat
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View article: Barriers to Care for Sleep Surgery at a Safety Net Hospital: Qualitative Patient Experiences
Barriers to Care for Sleep Surgery at a Safety Net Hospital: Qualitative Patient Experiences Open
Objective(s) Understanding barriers to surgical interventions for obstructive sleep apnea (OSA) is crucial to ensuring equity of access to OSA care. This study aims to understand the experiences of patients at a safety‐net hospital in gett…
View article: Trends in Complications of Pediatric Rhinosinusitis Before and During the COVID‐19 Era
Trends in Complications of Pediatric Rhinosinusitis Before and During the COVID‐19 Era Open
Objective To examine changes in trends of the incidence and characteristics of pediatric complicated rhinosinusitis with respect to the coronavirus disease 2019 (COVID‐19) pandemic. Study Design Retrospective cohort. Setting Single tertiar…
View article: Predictors of Decision to Pursue Sleep Surgery
Predictors of Decision to Pursue Sleep Surgery Open
Objective To identify predictors of patient decision to pursue sleep apnea surgery following initial consultation with a sleep surgeon. Study Design Retrospective cohort analysis. Setting Outpatient tertiary care academic center. Methods A…
View article: What are the Predictors of Success with Hypoglossal Nerve Stimulation?
What are the Predictors of Success with Hypoglossal Nerve Stimulation? Open
Obstructive sleep apnea (OSA) affects up to 4% of the adult population. Hypoglossal nerve stimulation (HNS) was approved by the FDA in 2014 as a treatment option for patients with moderate to severe OSA who cannot tolerate CPAP and, since …
View article: Patient Reported Outcome Measures used in Surgical Evaluation of Obstructive Sleep Apnea: A Systematic Review
Patient Reported Outcome Measures used in Surgical Evaluation of Obstructive Sleep Apnea: A Systematic Review Open
Objective To identify patient‐reported outcome measures (PROMs) used to measure adult obstructive sleep apnea (OSA)‐related quality of life in sleep surgery and analyze key psychometric properties in the original design and development of …
View article: Comparison of Chronic Sialadenitis Symptom Burden in Patients With Sialolithiasis Versus Stenosis Before and After Sialendoscopy
Comparison of Chronic Sialadenitis Symptom Burden in Patients With Sialolithiasis Versus Stenosis Before and After Sialendoscopy Open
Objective To define symptomatology and responses to treatment in chronic sialadenitis from sialolithiasis versus duct stenosis and establish a minimal clinically significant difference (MCID) in the validated Obstructive Salivary Problem I…
View article: Analysis of Internet‐Based Written Materials on Surgery for Obstructive Sleep Apnea
Analysis of Internet‐Based Written Materials on Surgery for Obstructive Sleep Apnea Open
Objective Obstructive sleep apnea (OSA) has many treatment options and the Internet is an important resource for patients. The quality of information reviewed by patients about sleep surgery is unknown. We assessed readability, accessibili…
View article: Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India
Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India Open
Background Telomeres are repetitive DNA sequences located at the ends of chromosomes, playing a vital role in maintaining chromosomal integrity and stability. Dysregulation of telomeres has been implicated in the development of various can…
View article: Cisplatin-based combination therapy for cancer
Cisplatin-based combination therapy for cancer Open
Cisplatin, that is, cis-diamminedichloroplatinum is a coordinate compound that is mainly preferred as prior treatment against several solid tumors and malignancies like ovaries, head and neck, testicular, and lung cancers because of its an…
View article: Figure S1 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Figure S1 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Figure S1. Bioinformatic analysis of differential lncRNA expression in LUAD. A. Table of samples included in the initial analysis. AEC = Alveolar Epithelial Cells. B. Volcano plot of differential analysis for lncRNA expression.
View article: Figure S6 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Figure S6 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Figure S6. TCGA LUAD methylation at the LINC00261 locus. A. Individual CpGs are denoted by their Illumina 450K designation. Scale = 0 (no methylation) to 1 (complete methylation). Hg19-based coordinates for each probe are listed below the …
View article: Figure S4 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Figure S4 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Figure S4. A. Migration of LINC00261 in A549 cell lines. The A549-shLINC00261 stable cell line and A549-shScrambled control were plated on transwell filters and measured by Violet blue staining. Statistical analysis was performed using a p…
View article: Figure S5 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Figure S5 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Figure S5. Gene expression analysis of LINC00261 co-regulated genes. A. Overlap between H522 differentially expressed genes. Blue circle = Differentially expressed genes in H522 RNAseq. Purple circle = genes co-expressed with LINC00261 in …
View article: Supplemental Tables 1,2,3 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Supplemental Tables 1,2,3 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Supplemental Table T1. List of Primers for LINC00261 detection and cloning. Supplemental Table T2. Differentially expressed lncRNAs in LUAD versus primary AEC. Supplemental Table T3. Differentially expressed genes in H522-CMV-LINC00261 vs …
View article: Figure S2 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Figure S2 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Figure S2. Further analysis of LINC00261 expression in multiple cancer types. A. Stratification of LINC00261 expression from TCGA LUSC samples based on stage at diagnosis. B. Upper panel: Overall survival of patients stratified by expressi…
View article: Figure S1 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Figure S1 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Figure S1. Bioinformatic analysis of differential lncRNA expression in LUAD. A. Table of samples included in the initial analysis. AEC = Alveolar Epithelial Cells. B. Volcano plot of differential analysis for lncRNA expression.
View article: Supplemental Tables 1,2,3 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Supplemental Tables 1,2,3 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Supplemental Table T1. List of Primers for LINC00261 detection and cloning. Supplemental Table T2. Differentially expressed lncRNAs in LUAD versus primary AEC. Supplemental Table T3. Differentially expressed genes in H522-CMV-LINC00261 vs …
View article: Figure S7 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Figure S7 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Figure S7. TCGA LUAD methylation at the FOXA2 locus. A. Individual CpGs are denoted by their Illumina 450K designation. Scale = 0 (no methylation) to 1 (complete methylation). Hg19-based coordinates for each probe are listed below the cg a…
View article: Figure S6 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Figure S6 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Figure S6. TCGA LUAD methylation at the LINC00261 locus. A. Individual CpGs are denoted by their Illumina 450K designation. Scale = 0 (no methylation) to 1 (complete methylation). Hg19-based coordinates for each probe are listed below the …
View article: Data from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Data from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Lung cancer is the leading cause of cancer-related death in the United States. Long noncoding RNAs (lncRNA) are a class of regulatory molecules whose role in lung carcinogenesis is poorly understood. In this study, we profiled lncRNA expre…
View article: Figure S5 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Figure S5 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Figure S5. Gene expression analysis of LINC00261 co-regulated genes. A. Overlap between H522 differentially expressed genes. Blue circle = Differentially expressed genes in H522 RNAseq. Purple circle = genes co-expressed with LINC00261 in …
View article: Figure S2 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Figure S2 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Figure S2. Further analysis of LINC00261 expression in multiple cancer types. A. Stratification of LINC00261 expression from TCGA LUSC samples based on stage at diagnosis. B. Upper panel: Overall survival of patients stratified by expressi…
View article: Figure S7 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Figure S7 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Figure S7. TCGA LUAD methylation at the FOXA2 locus. A. Individual CpGs are denoted by their Illumina 450K designation. Scale = 0 (no methylation) to 1 (complete methylation). Hg19-based coordinates for each probe are listed below the cg a…
View article: Figure S4 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Figure S4 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Figure S4. A. Migration of LINC00261 in A549 cell lines. The A549-shLINC00261 stable cell line and A549-shScrambled control were plated on transwell filters and measured by Violet blue staining. Statistical analysis was performed using a p…
View article: Figure S3 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Figure S3 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Figure S3. Characterization of stable H522-CMV-LINC00261 cell lines. A. qRT-PCR levels of LINC00261 expression in H522 cells transfected with ectopic CMV-LINC00261 and CMV-NEO backbone as the control vector. Three stable cells lines of eac…
View article: Data from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Data from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Lung cancer is the leading cause of cancer-related death in the United States. Long noncoding RNAs (lncRNA) are a class of regulatory molecules whose role in lung carcinogenesis is poorly understood. In this study, we profiled lncRNA expre…
View article: Figure S3 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Figure S3 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Open
Figure S3. Characterization of stable H522-CMV-LINC00261 cell lines. A. qRT-PCR levels of LINC00261 expression in H522 cells transfected with ectopic CMV-LINC00261 and CMV-NEO backbone as the control vector. Three stable cells lines of eac…
View article: Genetic Analysis of colorectal carcinoma using high throughput SNP genotyping technique within the population of Jammu and Kashmir
Genetic Analysis of colorectal carcinoma using high throughput SNP genotyping technique within the population of Jammu and Kashmir Open
Background SNP genotyping has become increasingly more common place to understand the genetic basis of complex diseases like cancer. SNP-genotyping through massARRAY is a cost-effective method to quantitatively analyse the variation of gen…
View article: Role of Paired Box 5 (PAX 5) Genetic Variant in the Development and Progression of Leukemia.
Role of Paired Box 5 (PAX 5) Genetic Variant in the Development and Progression of Leukemia. Open
Leukemia is a heterogeneous disorder, characterized by a high proliferation of white blood cells. Various genetic studies have tried to reveal the role of contributory SNPs responsible for the development of leukemia. The expression of thi…