Amrita Joshi
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View article: TNF-α represses fibroblast to myofibroblast transition through the histone methyltransferase Setdb2
TNF-α represses fibroblast to myofibroblast transition through the histone methyltransferase Setdb2 Open
Fibroblast to myofibroblast transition is a critical event required for effective tissue repair. In pathologic wound repair processes, such as type 2 diabetes (T2D), fibroblast to myofibroblast transition is impaired. The exact factors tha…
View article: The histone methyltransferase SETDB2 modulates keratinocyte inflammatory phenotype in diabetic wound repair via an IFNβ/JAK/STAT mechanism 2142
The histone methyltransferase SETDB2 modulates keratinocyte inflammatory phenotype in diabetic wound repair via an IFNβ/JAK/STAT mechanism 2142 Open
Description Diabetic keratinocytes overexpress inflammatory cytokines, contributing to prolonged inflammation and impaired healing. Using diet-induced obese (DIO) and db/db murine models of type 2 diabetes (T2D) and single-cell sequencing …
View article: A rare population of TGFB-expressing resident macrophages undergoes macrophage to myofibroblast transition during wound repair 2260
A rare population of TGFB-expressing resident macrophages undergoes macrophage to myofibroblast transition during wound repair 2260 Open
Description Precise regulation of macrophage phenotype is essential for normal wound healing, and macrophage to myofibroblast transition (MMT) has been reported in various diseases. We used spatial sequencing of human wounds to characteriz…
View article: 0535 The histone methyltransferase WHSC1 modulates keratinocyte proliferation in wounds via regulation of proliferation and differentiation marker expression
0535 The histone methyltransferase WHSC1 modulates keratinocyte proliferation in wounds via regulation of proliferation and differentiation marker expression Open
View article: The TGFβ-Whsc1 Axis Drives Macrophage to Myofibroblast Transition During Wound Repair
The TGFβ-Whsc1 Axis Drives Macrophage to Myofibroblast Transition During Wound Repair Open
View article: Microkeratome-assisted vs femtosecond laser-assisted superficial anterior lamellar keratoplasty: A randomized controlled trial
Microkeratome-assisted vs femtosecond laser-assisted superficial anterior lamellar keratoplasty: A randomized controlled trial Open
Purpose: The purpose is to compare the outcomes between microkeratome-assisted superficial anterior lamellar keratoplasty (MK-SALK) and femtosecond laser-assisted superficial anterior lamellar keratoplasty (FL-SALK) for superficial corneal…
View article: Epigenetic alteration of smooth muscle cells regulates endothelin-dependent blood pressure and hypertensive arterial remodeling
Epigenetic alteration of smooth muscle cells regulates endothelin-dependent blood pressure and hypertensive arterial remodeling Open
Long-standing hypertension (HTN) affects multiple organs and leads to pathologic arterial remodeling, which is driven by smooth muscle cell (SMC) plasticity. To identify relevant genes regulating SMC function in HTN, we considered Genome W…
View article: Inhibition of vascular smooth muscle cell PERK/ATF4 ER stress signaling protects against abdominal aortic aneurysms
Inhibition of vascular smooth muscle cell PERK/ATF4 ER stress signaling protects against abdominal aortic aneurysms Open
Abdominal aortic aneurysms (AAA) are a life-threatening cardiovascular disease for which there is a lack of effective therapy preventing aortic rupture. During AAA formation, pathological vascular remodeling is driven by vascular smooth mu…
View article: Efficacy & safety of brolucizumab 6.0 mg versus 3.6 mg in diabetic macular edema
Efficacy & safety of brolucizumab 6.0 mg versus 3.6 mg in diabetic macular edema Open
View article: The STAT3/SETDB2 axis dictates NF-κB–mediated inflammation in macrophages during wound repair
The STAT3/SETDB2 axis dictates NF-κB–mediated inflammation in macrophages during wound repair Open
Macrophage transition from an inflammatory to reparative phenotype after tissue injury is controlled by epigenetic enzymes that regulate inflammatory gene expression. We have previously identified that the histone methyltransferase SETDB2 …
View article: The histone methyltransferase Mixed-lineage-leukemia-1 drives T cell phenotype via Notch signaling in diabetic tissue repair
The histone methyltransferase Mixed-lineage-leukemia-1 drives T cell phenotype via Notch signaling in diabetic tissue repair Open
Immune cell-mediated inflammation is important in normal tissue regeneration but can be pathologic in diabetic wounds. Limited literature exists on the role of CD4+ T cells in normal or diabetic wound repair; however, the imbalance of CD4+…
View article: Epigenetic Alteration of Smooth Muscle Cells Regulates Endothelin-Dependent Blood Pressure and Hypertensive Arterial Remodeling
Epigenetic Alteration of Smooth Muscle Cells Regulates Endothelin-Dependent Blood Pressure and Hypertensive Arterial Remodeling Open
Long-standing hypertension (HTN) affects multiple organ systems and leads to pathologic arterial remodeling, which is driven largely by smooth muscle cell (SMC) plasticity. Although genome wide association studies (GWAS) have identified nu…
View article: Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells
Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells Open
Plasmacytoid dendritic cells (pDCs) are first responders to tissue injury, where they prime naive T cells. The role of pDCs in physiologic wound repair has been examined, but little is known about pDCs in diabetic wound tissue and their in…
View article: Diabetic wound keratinocytes induce macrophage JMJD3-mediated Nlrp3 expression via IL-1R signaling
Diabetic wound keratinocytes induce macrophage JMJD3-mediated Nlrp3 expression via IL-1R signaling Open
AbstractMacrophage (Mφ) plasticity is critical for normal wound repair; however, in type 2 diabetic wounds, Mφs persist in a low-grade inflammatory state that prevents the resolution of wound inflammation. Increased NLRP3 inflammaso…
View article: Diabetic Wound Keratinocytes Induce Macrophage JMJD3-Mediated Nlrp3 Expression via IL-1R Signaling
Diabetic Wound Keratinocytes Induce Macrophage JMJD3-Mediated Nlrp3 Expression via IL-1R Signaling Open
Macrophage (Mφ) plasticity is critical for normal wound repair; however, in type 2 diabetic wounds, Mφs persist in a low-grade inflammatory state that prevents the resolution of wound inflammation. Increased NLRP3 inflammasome activity has…
View article: Diabetic wound keratinocytes induce macrophage JMJD3-mediated Nlrp3 expression via IL-1R signaling
Diabetic wound keratinocytes induce macrophage JMJD3-mediated Nlrp3 expression via IL-1R signaling Open
AbstractMacrophage (Mφ) plasticity is critical for normal wound repair; however, in type 2 diabetic wounds, Mφs persist in a low-grade inflammatory state that prevents the resolution of wound inflammation. Increased NLRP3 inflammaso…
View article: Impaired Epigenetic Reprogramming prevents Fibroblast to Myofibroblast Transition in Diabetic Wounds
Impaired Epigenetic Reprogramming prevents Fibroblast to Myofibroblast Transition in Diabetic Wounds Open
View article: The Tgfb-Whsc1 Axis Drives Macrophage to Myofibroblast Transition During Wound Repair
The Tgfb-Whsc1 Axis Drives Macrophage to Myofibroblast Transition During Wound Repair Open
View article: Tnfa-setdb2 Pathway Regulates Fibroblast to Myofibroblast Transition in Wound Repair
Tnfa-setdb2 Pathway Regulates Fibroblast to Myofibroblast Transition in Wound Repair Open
View article: Evolving Trends in Corneal Surgery
Evolving Trends in Corneal Surgery Open
Corneal surgery has seen significant advancements in recent years, revolutionizing the way we treat various corneal conditions. These advancements have improved patient outcomes, reduced recovery time, and expanded the scope of treatable c…
View article: Corneal transplantation: A walk to vision
Corneal transplantation: A walk to vision Open
View article: Emerging Trends and Management of Congenital Nystagmus
Emerging Trends and Management of Congenital Nystagmus Open
Nystagmus is an involuntary, rhythmic oscillation of the eyes that leads to a reduction in visual acuity due to the displacement of the image from the fovea. As per the age of onset, it can be grouped into infantile nystagmus and acquired …
View article: Retinal Surgery Evolution with New Trends
Retinal Surgery Evolution with New Trends Open
Retinal surgery has undergone a complete transformation in the past century. The earliest reported results of Gonin et al . with ignipuncture in 1923 heralded the scientifically evidenced treatment of retinal detachment. The article follow…
View article: Eye on the Future: Virtual Reality Surgical Simulator
Eye on the Future: Virtual Reality Surgical Simulator Open
The virtual reality (VR) surgical simulator marks the beginning of an era of technology-based teaching which will help the trainees learn new perspectives on surgical anatomy and repeatedly practice intricate microsurgical steps to their w…
View article: The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase–Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development
The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase–Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development Open
Objective: To determine macrophage-specific alterations in epigenetic enzyme function contributing to the development of abdominal aortic aneurysms (AAAs). Background: AAA is a life-threatening disease, characterized by pathologic vascular…
View article: The histone methyltransferase Whsc1 regulates TGFβ-driven macrophage to myofibroblast transition
The histone methyltransferase Whsc1 regulates TGFβ-driven macrophage to myofibroblast transition Open
In normal wound healing, macrophages regulate early and late inflammation, allowing for resolution of tissue injury and subsequent healing. During normal tissue repair, macrophages undergo transition to myofibroblasts, which promote wound …
View article: IL-17A-mediated JMJD3 regulation of integrin alpha 3 gene expression alters migration of diabetic keratinocytes and impairs wound repair
IL-17A-mediated JMJD3 regulation of integrin alpha 3 gene expression alters migration of diabetic keratinocytes and impairs wound repair Open
Keratinocytes are key structural cells in cell migration during wound repair. Keratinocyte migration is dysfunctional in diabetes and results in non-healing, however, the reason for this is unclear. Using bulk and single cell sequencing, w…
View article: Diabetic wound macrophage IL6 drives fibroblast dysfunction via the histone methyltransferase, SETDB2
Diabetic wound macrophage IL6 drives fibroblast dysfunction via the histone methyltransferase, SETDB2 Open
Interactions between innate immune cells and structural cells are vital to proper tissue repair and regeneration after injury. Under pathologic conditions such as type 2 diabetes (T2D), Mϕs exist in a chronic inflammatory state that drives…
View article: Diabetic wound keratinocytes induce macrophage JMJD3-mediated <i>Nlrp3</i> expression via IL1R signaling
Diabetic wound keratinocytes induce macrophage JMJD3-mediated <i>Nlrp3</i> expression via IL1R signaling Open
Type 2 diabetic (T2D) wound Macrophages (Mϕs) display a delayed chronic inflammatory state that prevents the resolution of wound inflammation. Increased NLRP3 inflammasome gene expression and activation in Mϕs contributes to impaired wound…
View article: CUSTOMERS' SATISFACTION WITH APPLICATION BASED BANKING: AN EMPIRICAL STUDY OF UDAIPUR CITY
CUSTOMERS' SATISFACTION WITH APPLICATION BASED BANKING: AN EMPIRICAL STUDY OF UDAIPUR CITY Open
In the present era, Technology is affecting both qualitatively and quantitatively life of each and every one. The exponential growth of information technology has touched the lives of millions of people and introduced major changes in the …