Amro Mostafa
YOU?
Author Swipe
View article: Adiposome Lipidomic Shifts Following Bariatric Surgery in Association With Weight Loss and Cardiometabolic Benefit
Adiposome Lipidomic Shifts Following Bariatric Surgery in Association With Weight Loss and Cardiometabolic Benefit Open
Context Adiposomes carry bioactive lipids that shape systemic metabolism and vascular function. Objective Building on our previous findings that obese adiposomes are ceramide/free fatty acid–enriched and linked to dysfunction, we tested wh…
View article: Adiposome Proteomics Uncover Molecular Signatures of Cardiometabolic Risk in Obese Individuals
Adiposome Proteomics Uncover Molecular Signatures of Cardiometabolic Risk in Obese Individuals Open
Background: Adipose-derived extracellular vesicles (adiposomes) are emerging as key mediators of inter-organ communication, yet their molecular composition and role in obesity-related pathophysiology remain underexplored. This study integr…
View article: Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to obesity and cardiometabolic risk
Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to obesity and cardiometabolic risk Open
BACKGROUNDObesity, a growing health concern, often leads to metabolic disturbances, systemic inflammation, and vascular dysfunction. Emerging evidence suggests that adipose tissue-derived extracellular vesicles (adiposomes) may propagate o…
View article: Adipokines in the Crosstalk between Adipose Tissues and Other Organs: Implications in Cardiometabolic Diseases
Adipokines in the Crosstalk between Adipose Tissues and Other Organs: Implications in Cardiometabolic Diseases Open
Adipose tissue was previously regarded as a dormant organ for lipid storage until the identification of adiponectin and leptin in the early 1990s. This revelation unveiled the dynamic endocrine function of adipose tissue, which has expande…
View article: Comparison of Adiposomal Lipids between Obese and Non-Obese Individuals
Comparison of Adiposomal Lipids between Obese and Non-Obese Individuals Open
Our recent findings revealed that human adipose tissues (AT)-derived extracellular vesicles (adiposomes) vary in cargo among obese and lean individuals. The main objective of this study was to investigate the adiposomal lipid profiles and …
View article: Adiposomes from Obese-Diabetic Individuals Promote Endothelial Dysfunction and Loss of Surface Caveolae
Adiposomes from Obese-Diabetic Individuals Promote Endothelial Dysfunction and Loss of Surface Caveolae Open
Glycosphingolipids (GSLs) are products of lipid glycosylation that have been implicated in the development of cardiovascular diseases. In diabetes, the adipocyte microenvironment is characterized by hyperglycemia and inflammation, resultin…