Amulya K. Panda
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View article: A holistic perspective on analytical method validation under International Council for Harmonisation Q2(R1)
A holistic perspective on analytical method validation under International Council for Harmonisation Q2(R1) Open
Validation is a fundamental requirement for ensuring compliance with Good Laboratory Practices and Current Good Manufacturing Practices. Each and every pharmaceutical sector ensures testing of excipients. IPQC material like excipients, dru…
View article: Evaluation of Postendodontic Pain Using Multiple and Single Rotary File Systems in Single-Visit Endodontics - A Comparative Study
Evaluation of Postendodontic Pain Using Multiple and Single Rotary File Systems in Single-Visit Endodontics - A Comparative Study Open
A BSTRACT Background: Postendodontic pain is a common concern following root canal treatment. The rotary file system used during the procedure significantly influences this pain. Materials and Methods: A total of 60 patients requiring sing…
View article: CoviWall, a whole-virion-inactivated B.1.617.2 vaccine candidate, induces potent humoral and Th1 cell response in mice and protects against B.1.617.2 strain challenge in Syrian hamsters
CoviWall, a whole-virion-inactivated B.1.617.2 vaccine candidate, induces potent humoral and Th1 cell response in mice and protects against B.1.617.2 strain challenge in Syrian hamsters Open
Rapid development of coronavirus disease 2019 (COVID-19) vaccines and antiviral drugs have significantly reduced morbidity and mortality worldwide. Although most of the vaccines were developed initially with the ancestral Wuhan antigen, he…
View article: Stimuli responsive Magnetic-Silica-Poly lactic-co-glycolic acid hybrid nanoparticles for targeted cancer chemo-immunotherapy
Stimuli responsive Magnetic-Silica-Poly lactic-co-glycolic acid hybrid nanoparticles for targeted cancer chemo-immunotherapy Open
Due to the emergence of drug resistance by tumor cells against chemotherapeutic agents by multiple mechanisms i.e. apoptosis suppression, alteration in drug metabolism and efflux mechanisms, epigenetic factors and DNA repair mechanism and …
View article: Electrochemical Detection of Vibrio cholerae by Amine Functionalized Biocompatible Gadolinium Oxide Nanoparticles
Electrochemical Detection of Vibrio cholerae by Amine Functionalized Biocompatible Gadolinium Oxide Nanoparticles Open
Herein, we report the biocompatible amine-functionalized gadolinium oxide nanoparticles (Gd2O3 NPs) for the possibility of electrochemical detection of Vibrio cholerae (Vc) cells. The microwave irradiation process is applied to synthesize …
View article: Novel Peptide Inhibitor of Human Tumor Necrosis Factor-α has Antiarthritic Activity
Novel Peptide Inhibitor of Human Tumor Necrosis Factor-α has Antiarthritic Activity Open
The inhibition of tumor necrosis factor-α (TNFα) trimer formation renders it inactive for binding to its receptors thus mitigating the vicious cycle of inflammation. We designed a peptide (PIYLGGVFQ) that simulates a sequence strand of hum…
View article: Novel Peptide Inhibitor of Human Tumor Necrosis Factor-α has Antiarthritic Activity
Novel Peptide Inhibitor of Human Tumor Necrosis Factor-α has Antiarthritic Activity Open
The inhibition of tumor necrosis factor-α (TNFα) trimer formation renders it inactive for binding to its receptors thus mitigating the vicious cycle of inflammation. We designed a peptide (PIYLGGVFQ) that simulates a sequence strand of hum…
View article: Troxerutin-Mediated Complement Pathway Inhibition is a Disease-Modifying Treatment for Inflammatory Arthritis
Troxerutin-Mediated Complement Pathway Inhibition is a Disease-Modifying Treatment for Inflammatory Arthritis Open
Troxerutin (TXR) is a phytochemical reported to possess anti-inflammatory and hepatoprotective effects. In this study, we aimed to exploit the antiarthritic properties of TXR using an adjuvant-induced arthritic (AIA) rat model. AIA-induced…
View article: Expression and Characterization of in vitro Aggregates and Inclusion Bodies of α-synuclein in E. coli
Expression and Characterization of in vitro Aggregates and Inclusion Bodies of α-synuclein in E. coli Open
α-synuclein (SNCA gene) aggregation in neuronal cells causes Parkinson's disease (PD), one of the most common neurodegenerative diseases.Mutations in the SNCA gene locus and accumulation of metal ions are the major hallmarks in PD patients…
View article: Troxerutin-mediated C9 inhibition is a disease-modifying treatment for inflammatory arthritis.
Troxerutin-mediated C9 inhibition is a disease-modifying treatment for inflammatory arthritis. Open
Troxerutin (TXR) is a phytochemical reported to possess anti-inflammatory and hepatoprotective effects. In this study, we aimed to exploit anti-arthritic properties of TXR using an adjuvant induced arthritic (AIA) rat model. AIA induced ra…
View article: Molecular Attributes Associated With Refolding of Inclusion Body Proteins Using the Freeze–Thaw Method
Molecular Attributes Associated With Refolding of Inclusion Body Proteins Using the Freeze–Thaw Method Open
Understanding the structure–function of inclusion bodies (IBs) in the last two decades has led to the development of several mild solubilization buffers for the improved recovery of bioactive proteins. The recently developed freeze–thaw-ba…
View article: Maternal vitamin B<sub>12</sub> in mice positively regulates bone, but not muscle mass and strength in post-weaning and mature offspring
Maternal vitamin B<sub>12</sub> in mice positively regulates bone, but not muscle mass and strength in post-weaning and mature offspring Open
Vitamin B 12 deficiency has been shown to affect bone mass in rodents and negatively impact bone formation in humans. In this study using mouse models, we define the effect of B 12 supplementation in the wild-type mother and B 12 deficienc…
View article: Troxerutin acts on complement mediated inflammation to ameliorate arthritic symptoms in rats
Troxerutin acts on complement mediated inflammation to ameliorate arthritic symptoms in rats Open
Troxerutin (TXR), is a phytochemical reported to possess anti-inflammatory and hepatoprotective effects. In this study, we aimed to exploit anti-arthritic properties of TXR using an adjuvant induced arthritic (AIA) rat model. AIA induced r…
View article: Structure-Function Relationship of Inclusion Bodies of a Multimeric Protein
Structure-Function Relationship of Inclusion Bodies of a Multimeric Protein Open
High level expression of recombinant proteins in bacteria often results in their aggregation into inclusion bodies. Formation of inclusion bodies poses a major bottleneck in high-throughput recovery of recombinant protein. These aggregates…
View article: An efficient electrochemical biosensor for Vitamin-D3 detection based on aspartic acid functionalized gadolinium oxide nanorods
An efficient electrochemical biosensor for Vitamin-D3 detection based on aspartic acid functionalized gadolinium oxide nanorods Open
In this study, an efficient electrochemical biosensor for Vitamin-D3 detection using gadolinium oxide nanorods (Gd2O3NRs) has been reported. Gd2O3NRs were hydrothermally synthesized and functionalized with aspartic acid (Asp-Gd2O3NRs). Asp…
View article: Curcumin-Artesunate Based Polymeric Nanoparticle; Antiplasmodial and Toxicological Evaluation in Murine Model
Curcumin-Artesunate Based Polymeric Nanoparticle; Antiplasmodial and Toxicological Evaluation in Murine Model Open
Mainstay chemotherapy for malaria is often faced with the problem of instability and poor bio-distribution thus resulting in impaired pharmacokinetics. Nanomedicine has been acclaimed for its success in drug delivery and improved efficacy.…
View article: Poly(D,L-lactic-co-glycolic acid)-based artesunate nanoparticles: formulation, antimalarial and toxicity assessments
Poly(D,L-lactic-co-glycolic acid)-based artesunate nanoparticles: formulation, antimalarial and toxicity assessments Open
A simple treatment of PLGA-entrapped artesunate nanoparticles with dual advantages of low toxicity and better antiplasmodial efficacy has been developed.
View article: Antiplasmodial Activity and Toxicological Assessment of Curcumin PLGA-Encapsulated Nanoparticles
Antiplasmodial Activity and Toxicological Assessment of Curcumin PLGA-Encapsulated Nanoparticles Open
Curcumin is a polyphenolic pigment isolated from the rhizomes of Curcuma longa (turmeric), a medicinal plant widely used in the ancient Indian and Chinese medicine. The antiplasmodial activity of curcumin is often hampered by its fast meta…