Amy B. Knudsen
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View article: Benefits of colorectal cancer screening using fecal immunochemical testing with varying positivity thresholds by age and sex
Benefits of colorectal cancer screening using fecal immunochemical testing with varying positivity thresholds by age and sex Open
Background Fecal immunochemical test (FIT) performance for colorectal cancer screening varies by age and sex, yet most FIT-based screening programs use uniform positivity thresholds. This study assessed the potential benefits of stratifyin…
View article: One in three adenomas could be missed by white-light colonoscopy – findings from a systematic review and meta-analysis
One in three adenomas could be missed by white-light colonoscopy – findings from a systematic review and meta-analysis Open
View article: Emulator-Based Bayesian Calibration of the CISNET Colorectal Cancer Models
Emulator-Based Bayesian Calibration of the CISNET Colorectal Cancer Models Open
Purpose To calibrate Cancer Intervention and Surveillance Modeling Network (CISNET)’s SimCRC, MISCAN-Colon, and CRC-SPIN simulation models of the natural history colorectal cancer (CRC) with an emulator-based Bayesian algorithm and interna…
View article: Characteristics of a cost-effective blood test for colorectal cancer screening
Characteristics of a cost-effective blood test for colorectal cancer screening Open
Background Blood-based biomarker tests can potentially change the landscape of colorectal cancer (CRC) screening. We characterize the conditions under which blood test screening would be as effective and cost-effective as annual fecal immu…
View article: Effectiveness and Cost-Effectiveness of Colorectal Cancer Screening With a Blood Test That Meets the Centers for Medicare & Medicaid Services Coverage Decision
Effectiveness and Cost-Effectiveness of Colorectal Cancer Screening With a Blood Test That Meets the Centers for Medicare & Medicaid Services Coverage Decision Open
View article: Neonatal Respiratory Morbidity among Late Preterm Births by Planned Mode of Delivery and Gestational Age
Neonatal Respiratory Morbidity among Late Preterm Births by Planned Mode of Delivery and Gestational Age Open
Objective To estimate the effect of late preterm antenatal steroids on the absolute risk of respiratory morbidity among subgroups of patients based on the planned mode of delivery and gestational age at presentation. Methods This was a sec…
View article: Cost-Effectiveness Analysis of Screening for Pancreatic Cancer Among High-Risk Populations
Cost-Effectiveness Analysis of Screening for Pancreatic Cancer Among High-Risk Populations Open
PURPOSE We evaluated the potential cost-effectiveness of combined magnetic resonance imaging (MRI) and endoscopic ultrasound (EUS) screening for pancreatic ductal adenocarcinoma (PDAC) among populations at high risk for the disease. METHOD…
View article: Estimated US Cancer Deaths Prevented With Increased Use of Lung, Colorectal, Breast, and Cervical Cancer Screening
Estimated US Cancer Deaths Prevented With Increased Use of Lung, Colorectal, Breast, and Cervical Cancer Screening Open
Importance Increased use of recommended screening could help achieve the Cancer Moonshot goal of reducing US cancer deaths. Objective To estimate the number of cancer deaths that could be prevented with a 10–percentage point increase in th…
View article: NordICC Trial Results in Line With Expected Colorectal Cancer Mortality Reduction After Colonoscopy: A Modeling Study
NordICC Trial Results in Line With Expected Colorectal Cancer Mortality Reduction After Colonoscopy: A Modeling Study Open
Colonoscopy screening is a widely recommended method for detecting colorectal cancer (CRC) in countries across the world.1Schreuders E.H. et al.Gut. 2015; 64: 1637-1649Crossref PubMed Scopus (843) Google Scholar However, until recently, no…
View article: Ultrasound Surveillance of Small, Incidentally Detected Gallbladder Polyps: Projected Benefits by Sex, Age, and Comorbidity Level
Ultrasound Surveillance of Small, Incidentally Detected Gallbladder Polyps: Projected Benefits by Sex, Age, and Comorbidity Level Open
View article: Estimated Reductions in Opioid Overdose Deaths With Sustainment of Public Health Interventions in 4 US States
Estimated Reductions in Opioid Overdose Deaths With Sustainment of Public Health Interventions in 4 US States Open
Importance In 2021, more than 80 000 US residents died from an opioid overdose. Public health intervention initiatives, such as the Helping to End Addiction Long-term (HEALing) Communities Study (HCS), are being launched with the goal of r…
View article: Editorial for This Article from Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates
Editorial for This Article from Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates Open
Editorial for This Article from Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates
View article: Supplementary Appendix from Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates
Supplementary Appendix from Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates Open
PDF file - 149K, Appendix containing detailed model description, estimates of survival by race, age and gender over time and Formulas for Calculation of Disparities and Proportion of Disparities Explained by Screening and Survival
View article: Data from Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates
Data from Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates Open
Background: Considerable disparities exist in colorectal cancer (CRC) incidence and mortality rates between blacks and whites in the United States. We estimated how much of these disparities could be explained by differences in CRC …
View article: Supplementary Appendix from Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates
Supplementary Appendix from Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates Open
PDF file - 149K, Appendix containing detailed model description, estimates of survival by race, age and gender over time and Formulas for Calculation of Disparities and Proportion of Disparities Explained by Screening and Survival
View article: Editorial for This Article from Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates
Editorial for This Article from Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates Open
Editorial for This Article from Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates
View article: Data from Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates
Data from Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates Open
Background: Considerable disparities exist in colorectal cancer (CRC) incidence and mortality rates between blacks and whites in the United States. We estimated how much of these disparities could be explained by differences in CRC …
View article: Randomized Trial of Facilitated Adherence to Screening Colonoscopy vs Sequential Fecal-Based Blood Test
Randomized Trial of Facilitated Adherence to Screening Colonoscopy vs Sequential Fecal-Based Blood Test Open
View article: Emulator-based Bayesian calibration of the CISNET colorectal cancer models
Emulator-based Bayesian calibration of the CISNET colorectal cancer models Open
Purpose To calibrate Cancer Intervention and Surveillance Modeling Network (CISNET) ’s SimCRC, MISCAN-Colon, and CRC-SPIN simulation models of the natural history colorectal cancer (CRC) with an emulator-based Bayesian algorithm and intern…
View article: Characterization and Valuation of the Uncertainty of Calibrated Parameters in Microsimulation Decision Models
Characterization and Valuation of the Uncertainty of Calibrated Parameters in Microsimulation Decision Models Open
Background: We evaluated the implications of different approaches to characterize the uncertainty of calibrated parameters of microsimulation decision models (DMs) and quantified the value of such uncertainty in decision making. Methods: W…
View article: Colorectal Cancer Screening in Young Adults
Colorectal Cancer Screening in Young Adults Open
LettersJuly 2021Colorectal Cancer Screening in Young AdultsAmy B. Knudsen, PhD, Carolyn M. Rutter, PhD, Reinier G.S. Meester, PhD, Iris Lansdorp-Vogelaar, PhD, Ann G. Zauber, PhD, Karen M. Kuntz, ScDAmy B. Knudsen, PhDMassachusetts General…
View article: Colorectal Cancer Screening
Colorectal Cancer Screening Open
This microsimulation modeling analysis suggests that screening for colorectal cancer with stool tests, endoscopic tests, or computed tomography colonography starting at age 45 years provides an efficient balance of colonoscopy burden and l…
View article: Black and White Differences in Colorectal Cancer Screening and Screening Outcomes: A Narrative Review
Black and White Differences in Colorectal Cancer Screening and Screening Outcomes: A Narrative Review Open
Racial disparities in colorectal cancer incidence are widely documented. There are two potential mechanisms for these disparities: differences in access to screening, including screening follow-up, and differences in underlying risk of col…
View article: Validation of Colorectal Cancer Models on Long-term Outcomes from a Randomized Controlled Trial
Validation of Colorectal Cancer Models on Long-term Outcomes from a Randomized Controlled Trial Open
Microsimulation models are often used to predict long-term outcomes and guide policy decisions regarding cancer screening. The United Kingdom Flexible Sigmoidoscopy Screening (UKFSS) Trial examines a one-time intervention of flexible sigmo…
View article: Comparing the Cost-Effectiveness of Innovative Colorectal Cancer Screening Tests
Comparing the Cost-Effectiveness of Innovative Colorectal Cancer Screening Tests Open
Background Colorectal cancer (CRC) screening with colonoscopy and the fecal immunochemical test (FIT) is underused. Innovative tests could increase screening acceptance. This study determined which of the available alternatives is most pro…
View article: Intensity of Surveillance for Patients With Colorectal Adenomas
Intensity of Surveillance for Patients With Colorectal Adenomas Open
Letters17 March 2020Intensity of Surveillance for Patients With Colorectal AdenomasReinier G.S. Meester, PhD, Iris Lansdorp-Vogelaar, PhD, Sidney J. Winawer, MD, DSc, Ann G. Zauber, PhD, Amy B. Knudsen, PhD, and Uri Ladabaum, MD, MSReinier…
View article: High-Intensity Versus Low-Intensity Surveillance for Patients With Colorectal Adenomas
High-Intensity Versus Low-Intensity Surveillance for Patients With Colorectal Adenomas Open
National Cancer Institute.
View article: Potential survival benefits from optimized chemotherapy implementation in advanced ovarian cancer: Projections from a microsimulation model
Potential survival benefits from optimized chemotherapy implementation in advanced ovarian cancer: Projections from a microsimulation model Open
Population-level life expectancy in stage IIIC epithelial ovarian cancer could be substantially improved through greater uptake of available chemotherapy regimens.
View article: Cost-effectiveness of a multitarget stool DNA test for colorectal cancer screening of Medicare beneficiaries
Cost-effectiveness of a multitarget stool DNA test for colorectal cancer screening of Medicare beneficiaries Open
Compared to no screening, triennial mtSDNA screening reduces CRC incidence and mortality at acceptable costs. However, compared to nearly all other CRC screening strategies reimbursed by CMS it is less effective and considerably more costl…
View article: Characterization and valuation of uncertainty of calibrated parameters in stochastic decision models
Characterization and valuation of uncertainty of calibrated parameters in stochastic decision models Open
We evaluated the implications of different approaches to characterize uncertainty of calibrated parameters of stochastic decision models (DMs) in the quantified value of such uncertainty in decision making. We used a microsimulation DM of …