Amy Baumgartner
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View article: Glycemia, Insulin Sensitivity, and Secretion Improve 3 Months Post-sleeve Gastrectomy in Youth With Type 2 Diabetes
Glycemia, Insulin Sensitivity, and Secretion Improve 3 Months Post-sleeve Gastrectomy in Youth With Type 2 Diabetes Open
Context Metabolic bariatric surgery reduces weight in youth with severe obesity; however, its impacts on youth-onset type 2 diabetes (T2D) are unclear. Objective We evaluated short-term outcomes in youth with T2D 3 months after vertical sl…
View article: 370 Epicardial adipose tissue and cardiometabolic health in youth-onset type 2 diabetes undergoing vertical sleeve gastrectomy
370 Epicardial adipose tissue and cardiometabolic health in youth-onset type 2 diabetes undergoing vertical sleeve gastrectomy Open
OBJECTIVES/GOALS: The goal of this study is to investigate the potential independent relationship between epicardial adipose tissue (EAT) and cardiometabolic health in youth-onset type 2 diabetes (T2D) and explore changes in EAT as a poten…
View article: Bromocriptine Improves Central Aortic Stiffness in Adolescents With Type 1 Diabetes: Arterial Health Results From the BCQR-T1D Study
Bromocriptine Improves Central Aortic Stiffness in Adolescents With Type 1 Diabetes: Arterial Health Results From the BCQR-T1D Study Open
Background: The presence of vascular dysfunction is a well-recognized feature in youth with type 1 diabetes (T1D), accentuating their lifetime risk of cardiovascular events. Therapeutic strategies to mitigate vascular dysfunction are a hig…
View article: Bromocriptine <scp>quick‐release</scp> as adjunct therapy in youth and adults with type 1 diabetes: A randomized, <scp>placebo‐controlled</scp> crossover study
Bromocriptine <span>quick‐release</span> as adjunct therapy in youth and adults with type 1 diabetes: A randomized, <span>placebo‐controlled</span> crossover study Open
Aim To evaluate the potential for glycaemic, renal and vascular benefits of bromocriptine quick release (BCQR) in adolescents and adults with type 1 diabetes. Materials and Methods Forty adolescents and 40 adults with type 1 diabetes aged …
View article: Impact of Obesity on Measures of Cardiovascular and Kidney Health in Youth With Type 1 Diabetes as Compared With Youth With Type 2 Diabetes
Impact of Obesity on Measures of Cardiovascular and Kidney Health in Youth With Type 1 Diabetes as Compared With Youth With Type 2 Diabetes Open
OBJECTIVE Insulin resistance and obesity are independently associated with type 1 diabetes (T1D) and are known risk factors for cardiovascular and kidney diseases, the leading causes of death in T1D. We evaluated the effect of BMI on cardi…
View article: Results from the Effects of <scp>ME</scp> tformin on cardiovascula <scp>R</scp> function in <scp>A</scp> do <scp>L</scp> escents with type 1 Diabetes ( <scp>EMERALD</scp> ) study: A brief report of kidney and inflammatory outcomes
Results from the Effects of <span>ME</span> tformin on cardiovascula <span>R</span> function in <span>A</span> do <span>L</span> escents with type 1 Diabetes ( <span>EMERALD</span> ) study: A brief report of kidney and inflammatory outcomes Open
Youth with type 1 diabetes (T1D) demonstrate insulin resistance, independently of glycaemia, when compared to normoglycaemic peers. Insulin resistance increases the risk of cardiovascular disease and diabetic kidney disease, factors also a…
View article: Muscle Insulin Resistance in Youth with Obesity and Normoglycemia is Associated with Altered Fat Metabolism
Muscle Insulin Resistance in Youth with Obesity and Normoglycemia is Associated with Altered Fat Metabolism Open
Objective This study aimed to phenotype and compare adipose, hepatic, and muscle insulin sensitivity (IS) in a diet‐ and physical activity–controlled cohort of normoglycemic youth with obesity with that of participants without obesity (con…
View article: Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance
Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance Open
Adolescents with type 2 diabetes (T2D) have severe insulin resistance (IR) secondary to obesity, genetics, and puberty, and IR predicts metabolic comorbidities. Adults with T2D have multitissue IR, which has guided therapeutic developments…
View article: Metformin Improves Insulin Sensitivity and Vascular Health in Youth With Type 1 Diabetes Mellitus
Metformin Improves Insulin Sensitivity and Vascular Health in Youth With Type 1 Diabetes Mellitus Open
Background: Cardiovascular disease is the leading cause of mortality in type 1 diabetes mellitus (T1DM) and relates strongly to insulin resistance (IR). Lean and obese adolescents with T1DM have marked IR. Metformin improves surrogate mark…
View article: Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance
Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance Open
Adolescents with T1D have adipose, hepatic and peripheral IR. This IR occurs regardless of obesity and metabolic syndrome features. Youth with T1D may benefit from interventions directed at improving IR in these tissues, and this area requ…
View article: Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies
Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies Open
ADA/ISPAD goal achievement was associated with greater IS and cardiopulmonary fitness.
View article: Alternate glycemic markers reflect glycemic variability in continuous glucose monitoring in youth with prediabetes and type 2 diabetes
Alternate glycemic markers reflect glycemic variability in continuous glucose monitoring in youth with prediabetes and type 2 diabetes Open
Alternate glycemic markers predict glycemic variability as measured by CGM in youth with prediabetes and T2D. After adjusting for HbA1c, these alternate markers continued to predict components of glycemic variability detected by CGM.
View article: Hepatic Steatosis is Common in Adolescents with Obesity and <scp>PCOS</scp> and Relates to <i>De Novo</i> Lipogenesis but not Insulin Resistance
Hepatic Steatosis is Common in Adolescents with Obesity and <span>PCOS</span> and Relates to <i>De Novo</i> Lipogenesis but not Insulin Resistance Open
Objective Increased liver fat and type 2 diabetes are prevalent in women with polycystic ovarian syndrome (PCOS) and cause excess mortality, yet little is known about their development during adolescence. The objective of this study was to…
View article: The role of glycemia in insulin resistance in youth with type 1 and type 2 diabetes
The role of glycemia in insulin resistance in youth with type 1 and type 2 diabetes Open
Markers of metabolic syndrome and hyperglycemia predicted decreased IS in T2D youth. Paradoxically, hypoglycemia predicted decreased IS in T1D youth and hyperglycemia, particularly overnight, predicted improved IS. These preliminary result…
View article: Cardiopulmonary Dysfunction and Adiponectin in Adolescents With Type 2 Diabetes
Cardiopulmonary Dysfunction and Adiponectin in Adolescents With Type 2 Diabetes Open
Background Myocardial mechanics are altered in adults with obesity and type 2 diabetes (T2D); insulin resistance and adipokines have been implicated as important risk factors for cardiovascular disease, but these relationships are poorly d…
View article: Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids
Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids Open
Hyperandrogenic syndrome (HAS) is associated with insulin resistance (IR) and type 2 diabetes. Muscle IR in type 2 diabetes is linked with defects in mitochondrial oxidative capacity. In vivo muscle mitochondrial function has not been stud…