Amy Coe
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View article: The WiserAD Trial: Protocol for the Pragmatic, Randomised Controlled Trial of a Structured Online Support Intervention to Inform and Assist Antidepressant Deprescribing in Primary Care. (Preprint)
The WiserAD Trial: Protocol for the Pragmatic, Randomised Controlled Trial of a Structured Online Support Intervention to Inform and Assist Antidepressant Deprescribing in Primary Care. (Preprint) Open
BACKGROUND The use of antidepressant medications is increasing globally. However, despite their obvious benefits, there is reason to believe that ongoing use of these medications is often not properly monitored or deprescribed when a pers…
View article: Plasma and CSF neurofilament light chain distinguish neurodegenerative from primary psychiatric conditions in a clinical setting
Plasma and CSF neurofilament light chain distinguish neurodegenerative from primary psychiatric conditions in a clinical setting Open
INTRODUCTION People with neurodegenerative disorders (ND) frequently face diagnostic delay and misdiagnosis. We investigated blood and cerebrospinal fluid (CSF) neurofilament light chain (NfL) to distinguish ND from primary psychiatric dis…
View article: Plasma and CSF neurofilament light chain distinguish neurodegenerative from primary psychiatric conditions in a clinical setting
Plasma and CSF neurofilament light chain distinguish neurodegenerative from primary psychiatric conditions in a clinical setting Open
INTRODUCTION Many patients with neurodegenerative disorders (ND) face diagnostic delay and misdiagnosis. We investigated blood and cerebrospinal fluid (CSF) neurofilament light chain (NfL) to distinguish ND from primary psychiatric disorde…
View article: Social media group support for antidepressant deprescribing: a mixed-methods survey of patient experiences
Social media group support for antidepressant deprescribing: a mixed-methods survey of patient experiences Open
Background Antidepressant use has continually increased in recent decades and although they are an effective treatment for moderate-to-severe depression, when there is no longer a clinical benefit, deprescribing should occur. Currently, ro…
View article: Understanding Australian general practice patients’ decisions to deprescribe antidepressants in the WiserAD trial: a realist informed approach
Understanding Australian general practice patients’ decisions to deprescribe antidepressants in the WiserAD trial: a realist informed approach Open
Objectives To evaluate how an approach to antidepressant deprescribing works, for whom, and in what contexts by (1) examining the experiences and perceptions of the approach for antidepressant users, (2) identifying the mechanisms of the a…
View article: A mixed-methods evaluation of the impacts of an online Carer wellbeing and connection program
A mixed-methods evaluation of the impacts of an online Carer wellbeing and connection program Open
The online program effectively reduced psychological distress and loneliness and improved carer wellbeing.
View article: Plasma neurofilament light in behavioural variant frontotemporal dementia compared to mood and psychotic disorders
Plasma neurofilament light in behavioural variant frontotemporal dementia compared to mood and psychotic disorders Open
Objective Blood biomarkers of neuronal injury such as neurofilament light (NfL) are being intensively studied to improve diagnosis and treatment of neurodegenerative disorders, but gaps remain in its ability to assist in distinguishing neu…
View article: Self-reported reasons for reducing or stopping antidepressant medications in primary care: thematic analysis of the <i>diamond</i> longitudinal study
Self-reported reasons for reducing or stopping antidepressant medications in primary care: thematic analysis of the <i>diamond</i> longitudinal study Open
Background: Current treatment guidelines advise that the deprescribing of antidepressants should occur around 6 months post-remission of symptoms. However, this is not routinely occurring in clinical practice, with between 30% and 50% of a…
View article: General Practice Patients’ Experiences and Perceptions of the WiserAD Structured Web-Based Support Tool for Antidepressant Deprescribing: Protocol for a Mixed Methods Case Study With Realist Evaluation
General Practice Patients’ Experiences and Perceptions of the WiserAD Structured Web-Based Support Tool for Antidepressant Deprescribing: Protocol for a Mixed Methods Case Study With Realist Evaluation Open
Background Research suggests that the rapid increase in worldwide antidepressant use is mainly due to a rise in long-term and potentially inappropriate use. It has been suggested that 1 in 3 antidepressant users among general practice pati…
View article: A mixed methods case study realist evaluation of the WiserAD structured online support tool for antidepressant deprescribing in general practice: A study protocol (Preprint)
A mixed methods case study realist evaluation of the WiserAD structured online support tool for antidepressant deprescribing in general practice: A study protocol (Preprint) Open
BACKGROUND Research suggests that the rapid increase in worldwide antidepressant use is mainly due to a rise in long-term and potentially inappropriate use. General practice patients who are no longer experiencing clinical benefit from th…
View article: Economic evaluation of the Target-D platform to match depression management to severity prognosis in primary care: A within-trial cost-utility analysis
Economic evaluation of the Target-D platform to match depression management to severity prognosis in primary care: A within-trial cost-utility analysis Open
Background Target-D, a new person-centred e-health platform matching depression care to symptom severity prognosis (minimal/mild, moderate or severe) has demonstrated greater improvement in depressive symptoms than usual care plus attentio…
View article: Deprescribing intervention activities mapped to guiding principles for use in general practice: a scoping review
Deprescribing intervention activities mapped to guiding principles for use in general practice: a scoping review Open
Objective To identify and characterise activities for deprescribing used in general practice and to map the identified activities to pioneering principles of deprescribing. Setting Primary care. Data sources Medline, EMBASE (Ovid), CINAHL,…
View article: Matching depression management to severity prognosis in primary care: results of the Target-D randomised controlled trial
Matching depression management to severity prognosis in primary care: results of the Target-D randomised controlled trial Open
Background Mental health treatment rates are increasing, but the burden of disease has not reduced. Tools to support efficient resource distribution are required. Aim To investigate whether a person-centred e-health (Target-D) platform mat…
View article: Development of a Mobile Clinical Prediction Tool to Estimate Future Depression Severity and Guide Treatment in Primary Care: User-Centered Design
Development of a Mobile Clinical Prediction Tool to Estimate Future Depression Severity and Guide Treatment in Primary Care: User-Centered Design Open
User-centered design led to valuable improvements in the content and design of an app designed to improve allocation of and engagement in depression treatment. Iterative design allowed us to develop a tool that allows users to feel hope, e…
View article: Development of a Mobile Clinical Prediction Tool to Estimate Future Depression Severity and Guide Treatment in Primary Care: User-Centered Design
Development of a Mobile Clinical Prediction Tool to Estimate Future Depression Severity and Guide Treatment in Primary Care: User-Centered Design Open
Background: Around the world, depression is both under- and overtreated. The diamond clinical prediction tool was developed to assist with appropriate treatment allocation by estimating the 3-month prognosis among people with current depre…
View article: Informal Mentors Supporting Beginning Teachers in Professional Confidence and Classroom Management at a Private School
Informal Mentors Supporting Beginning Teachers in Professional Confidence and Classroom Management at a Private School Open
The purpose of the study was to evaluate the impact of informal mentoring on new teacher statements of professional confidence and perceptions of classroom management.
\nThe study was designed to use experienced teachers to help mentor new…