Amy E. Danson
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View article: De novo design of high-affinity protein binders with AlphaProteo
De novo design of high-affinity protein binders with AlphaProteo Open
Computational design of protein-binding proteins is a fundamental capability with broad utility in biomedical research and biotechnology. Recent methods have made strides against some target proteins, but on-demand creation of high-affinit…
View article: High-Throughput Protein Crystallization <em>via</em> Microdialysis
High-Throughput Protein Crystallization <em>via</em> Microdialysis Open
Understanding the structure-function relationships of macromolecules, such as proteins, at the molecular level is vital for biomedicine and modern drug discovery. To date, X-ray crystallography remains the most successful method for solvin…
View article: Measuring Protein Aggregation and Stability Using High-Throughput Biophysical Approaches
Measuring Protein Aggregation and Stability Using High-Throughput Biophysical Approaches Open
Structure-function relationships of biological macromolecules, in particular proteins, provide crucial insights for fundamental biochemistry, medical research and early drug discovery. However, production of recombinant proteins, either fo…
View article: Super-Resolution Fluorescence Microscopy Reveals Clustering Behaviour of Chlamydia pneumoniae’s Major Outer Membrane Protein
Super-Resolution Fluorescence Microscopy Reveals Clustering Behaviour of Chlamydia pneumoniae’s Major Outer Membrane Protein Open
Chlamydia pneumoniae is a Gram-negative bacterium responsible for a number of human respiratory diseases and linked to some chronic inflammatory diseases. The major outer membrane protein (MOMP) of Chlamydia is a conserved immunologically …
View article: Bacterial Enhancer Binding Proteins—AAA+ Proteins in Transcription Activation
Bacterial Enhancer Binding Proteins—AAA+ Proteins in Transcription Activation Open
Bacterial enhancer-binding proteins (bEBPs) are specialised transcriptional activators. bEBPs are hexameric AAA+ ATPases and use ATPase activities to remodel RNA polymerase (RNAP) complexes that contain the major variant sigma factor, σ54 …
View article: Structure-function characterisation of Chlamydia pneumoniae’s major outer membrane protein
Structure-function characterisation of Chlamydia pneumoniae’s major outer membrane protein Open
Chlamydia pneumoniae is a Gram negative bacterium responsible for a number of human respiratory diseases and linked to some chronic inflammatory diseases. The major outer membrane protein (MOMP) of Chlamydia is a conserved immunologically …
View article: Structure–function characterisation of <i>Chlamydia pneumoniae</i> MOMP
Structure–function characterisation of <i>Chlamydia pneumoniae</i> MOMP Open
Major outer membrane proteins (MOMPs) are structurally and immunologically dominant proteins in the Chlam ydia outer membrane.Both the surface exposure and abundance of MOMP suggests a possible role in Chlam ydia-host interactions, highlig…