Amy E. McGrath
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View article: Genetic Encoding of <i>para</i>-Pentafluorosulfanyl Phenylalanine: A Highly Hydrophobic and Strongly Electronegative Group for Stable Protein Interactions
Genetic Encoding of <i>para</i>-Pentafluorosulfanyl Phenylalanine: A Highly Hydrophobic and Strongly Electronegative Group for Stable Protein Interactions Open
SF5Phe, para-pentafluorosulfanyl phenylalanine, is an unnatural amino acid with extreme physicochemical properties, which is stable in physiological conditions. Here we present newly developed aminoacyl-tRNA synthetases that enable genetic…
View article: Single-molecule live-cell imaging reveals RecB-dependent function of DNA polymerase IV in double strand break repair
Single-molecule live-cell imaging reveals RecB-dependent function of DNA polymerase IV in double strand break repair Open
Several functions have been proposed for the Escherichia coli DNA polymerase IV (pol IV). Although much research has focused on a potential role for pol IV in assisting pol III replisomes in the bypass of lesions, pol IV is rarely found at…
View article: Modulation of DNA polymerase IV activity by UmuD and RecA* observed by single-molecule time-lapse microscopy
Modulation of DNA polymerase IV activity by UmuD and RecA* observed by single-molecule time-lapse microscopy Open
DNA polymerase IV (pol IV) is expressed at increased levels in Escherichia coli cells suffering high levels of DNA damage. In a recent single-molecule imaging study, we demonstrated that elevating the pol IV concentration is not sufficient…
View article: Rational Design of a 3<sub>10</sub>‐Helical PIP‐Box Mimetic Targeting PCNA, the Human Sliding Clamp
Rational Design of a 3<sub>10</sub>‐Helical PIP‐Box Mimetic Targeting PCNA, the Human Sliding Clamp Open
Invited for the cover of this issue is the group of John B. Bruning at The University of Adelaide. The image depicts PCNA (the human sliding clamp) shown as a protein surface representation (colored in grey) in complex with the first p21‐d…
View article: Front Cover: Rational Design of a 3<sub>10</sub>‐Helical PIP‐Box Mimetic Targeting PCNA, the Human Sliding Clamp (Chem. Eur. J. 44/2018)
Front Cover: Rational Design of a 3<sub>10</sub>‐Helical PIP‐Box Mimetic Targeting PCNA, the Human Sliding Clamp (Chem. Eur. J. 44/2018) Open
PCNA Space Odyssey: PCNA (the human sliding clamp) is depicted as a protein surface representation (colored in grey) in complex with the first p21-derived peptide mimetic inhibitor (shown as sticks colored by element). Protein amino acids …
View article: Structural and Functional Studies of the β2-Sliding Clamp from Pathogenic Bacteria
Structural and Functional Studies of the β2-Sliding Clamp from Pathogenic Bacteria Open
The introduction of antibiotics in medicine revolutionised the treatment of common bacterial infections. However, bacteria have overcome the obstacles imposed by these compounds via several mechanisms. As a consequence, they are rapidly be…