Amy E. Sheehan
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View article: Astrocyte-dependent local neurite pruning in Beat-Va neurons
Astrocyte-dependent local neurite pruning in Beat-Va neurons Open
Developmental neuronal remodeling is extensive and mechanistically diverse across the nervous system. We sought to identify Drosophila pupal neurons that underwent mechanistically new types of neuronal remodeling and describe remodeling Be…
View article: An Ionic Sensor acts in Parallel to dSarm to Promote Neurodegeneration
An Ionic Sensor acts in Parallel to dSarm to Promote Neurodegeneration Open
How neurons to sense when they are terminally dysfunctional and activate neurodegeneration remains poorly defined. The pro-degenerative NAD + hydrolase dSarm/SARM1 can act as a metabolic sensor by detecting pathological changes in NAD + /N…
View article: Developmental and age-related synapse elimination is mediated by glial Croquemort
Developmental and age-related synapse elimination is mediated by glial Croquemort Open
Summary Neurons and glia work together to dynamically regulate neural circuit assembly and maintenance. In this study, we show Drosophila exhibit large-scale synapse formation and elimination as part of normal CNS circuit maturation, and t…
View article: Astrocyte-dependent local neurite pruning and Hox gene-mediated cell death in Beat-Va neurons
Astrocyte-dependent local neurite pruning and Hox gene-mediated cell death in Beat-Va neurons Open
Neuronal remodeling is extensive and mechanistically diverse across the nervous systems of complex metazoans. To explore circuit refinement mechanisms, we screened for new neuronal subtypes in the Drosophila nervous system that undergo rem…
View article: Tweek-dependent formation of ER-PM contact sites enables astrocyte phagocytic function and remodeling of neurons
Tweek-dependent formation of ER-PM contact sites enables astrocyte phagocytic function and remodeling of neurons Open
Summary Neuronal remodeling generates an enormous amount of cellular debris, which is cleared from the nervous system by glia. At the larva-to-adult transition, Drosophila astrocytes transform into phagocytes and engulf degenerating larval…
View article: <i>Discoidin domain receptor</i> regulates ensheathment, survival and caliber of peripheral axons
<i>Discoidin domain receptor</i> regulates ensheathment, survival and caliber of peripheral axons Open
Most invertebrate axons and small-caliber axons in mammalian peripheral nerves are unmyelinated but still ensheathed by glia. Here, we use Drosophila wrapping glia to study the development and function of non-myelinating axon ensheathment,…
View article: Glial TGFβ activity promotes neuron survival in peripheral nerves
Glial TGFβ activity promotes neuron survival in peripheral nerves Open
Maintaining long, energetically demanding axons throughout the life of an animal is a major challenge for the nervous system. Specialized glia ensheathe axons and support their function and integrity throughout life, but glial support mech…
View article: Astrocyte growth during morphogenesis is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor
Astrocyte growth during morphogenesis is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor Open
SUMMARY Astrocytes play crucial roles in regulating neural circuit function by forming a dense network of synapse-associated membrane specializations, but signaling pathways regulating astrocyte morphogenesis remain poorly defined. Here we…
View article: <i>Discoidin domain receptor</i> regulates ensheathment, survival, and caliber of peripheral axons
<i>Discoidin domain receptor</i> regulates ensheathment, survival, and caliber of peripheral axons Open
Invertebrate axons and small caliber axons in mammalian peripheral nerves are unmyelinated but still ensheathed by glia. How this type of ensheathment is controlled and its roles in supporting neuronal function remain unclear. Here we use …
View article: Glial TGFβ activity promotes axon survival in peripheral nerves
Glial TGFβ activity promotes axon survival in peripheral nerves Open
Axons can represent the majority of the volume of a neuron and are energetically very demanding. Specialized glia ensheathe axons and are believed to support axon function and maintenance throughout life, but molecular details of glia-neur…
View article: TSG101 negatively regulates mitochondrial biogenesis in axons
TSG101 negatively regulates mitochondrial biogenesis in axons Open
Significance Mitochondrial dysfunction has been associated with many age-dependent neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease, yet understanding how a neuron maintains a pool of functional mitochondria in suffi…
View article: Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation
Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation Open
Mitochondria are essential in long axons to provide metabolic support and sustain neuron integrity. A healthy mitochondrial pool is maintained by biogenesis, transport, mitophagy, fission, and fusion, but how these events are regulated in …
View article: The secreted neurotrophin Spätzle 3 promotes glial morphogenesis and supports neuronal survival and function
The secreted neurotrophin Spätzle 3 promotes glial morphogenesis and supports neuronal survival and function Open
Most glial functions depend on establishing intimate morphological relationships with neurons. Significant progress has been made in understanding neuron–glia signaling at synaptic and axonal contacts, but how glia support neuronal cell bo…
View article: Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling
Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling Open
Draper/Ced-1/MEGF-10 is an engulfment receptor that promotes clearance of cellular debris in C. elegans , Drosophila and mammals. Draper signals through an evolutionarily conserved Src family kinase cascade to drive cytoskeletal rearrangem…