Amy E. Solinski
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View article: Structural Evidence for DUF512 as a Radical <i>S</i>-Adenosylmethionine Cobalamin-Binding Domain
Structural Evidence for DUF512 as a Radical <i>S</i>-Adenosylmethionine Cobalamin-Binding Domain Open
Cobalamin (Cbl)-dependent radical S-adenosylmethionine (SAM) enzymes constitute a large subclass of radical SAM (RS) enzymes that use Cbl to catalyze various types of reactions, the most common of which are methylations. Most Cbl-dependent…
View article: In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe
In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe Open
Natural products are important precursors for antibiotic drug design. These chemical scaffolds serve as synthetic inspiration for chemists who leverage their structures to develop novel antibacterials and chemical probes. We have previousl…
View article: Characterization of LipS1 and LipS2 from <i>Thermococcus kodakarensis</i>: Proteins Annotated as Biotin Synthases, which Together Catalyze Formation of the Lipoyl Cofactor
Characterization of LipS1 and LipS2 from <i>Thermococcus kodakarensis</i>: Proteins Annotated as Biotin Synthases, which Together Catalyze Formation of the Lipoyl Cofactor Open
Lipoic acid is an eight-carbon sulfur-containing biomolecule that functions primarily as a cofactor in several multienzyme complexes. It is biosynthesized as an attachment to a specific lysyl residue on one of the subunits of these multien…
View article: A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism
A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism Open
Targeting Streptococcus mutans is the primary focus in reducing dental caries, one of the most common maladies in the world. Previously, our groups discovered a potent bactericidal biaryl compound that was inspired by the natural product h…
View article: Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in <i>Streptococcus mutans</i>
Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in <i>Streptococcus mutans</i> Open
Understanding the broader biological impact of carolacton, a macrolactone natural product, has been ongoing for the past decade. Multiple studies have shown connections to regulatory systems, acid tolerance mechanisms, biofilm formation, a…
View article: The Natural Product Elegaphenone Potentiates Antibiotic Effects against <i>Pseudomonas aeruginosa</i>
The Natural Product Elegaphenone Potentiates Antibiotic Effects against <i>Pseudomonas aeruginosa</i> Open
Natural products represent a rich source of antibiotics that address versatile cellular targets. The deconvolution of their targets via chemical proteomics is often challenged by the introduction of large photocrosslinkers. Here we applied…
View article: Targeting <i>S. mutans</i> biofilms: a perspective on preventing dental caries
Targeting <i>S. mutans</i> biofilms: a perspective on preventing dental caries Open
This review aims to provide an overview of the current small molecule strategies used for targeting S. mutans biofilms, and a perspective of the future for the field.
View article: Honokiol-Inspired Analogs as Inhibitors of Oral Bacteria
Honokiol-Inspired Analogs as Inhibitors of Oral Bacteria Open
The oral microbiome is a complex ecological niche where both commensal and pathogenic bacteria coexist. Previous reports have cited that the plant isolate honokiol is a potent inhibitor of S. mutans biofilms. Herein we report a cross-coupl…
View article: Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in <i>Streptococcus mutans</i> Biofilms
Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in <i>Streptococcus mutans</i> Biofilms Open
The oral microbiome is a dynamic environment inhabited by both commensals and pathogens. Among these is Streptococcus mutans, the causative agent of dental caries, the most prevalent childhood disease. Carolacton has remarkably specific ac…
View article: An unexpected aromatization reaction during the preparation of 1,2-cyclohexanedione ethers
An unexpected aromatization reaction during the preparation of 1,2-cyclohexanedione ethers Open
In a heretofore-unreported reaction, 1,2-cyclohexandione reacts with a variety of alcohols under mild acid-catalyzed dehydration conditions to afford not only ethers of 1,2-cyclohexanedione but the corresponding aryl ethers as well in mode…