Amy S. Fox
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View article: A-231 Prediction of Severe COVID-19 Based on Routine Biomarker Assessment
A-231 Prediction of Severe COVID-19 Based on Routine Biomarker Assessment Open
Background Disease courses in COVID-19 patients vary widely. Prior studies did not focus on initial values of various laboratory biomarkers, instead used data throughout the disease course. Prediction of disease severity based on parameter…
View article: Risk Estimation of Severe COVID-19 Based on Initial Biomarker Assessment Across Racial and Ethnic Groups
Risk Estimation of Severe COVID-19 Based on Initial Biomarker Assessment Across Racial and Ethnic Groups Open
Context.— Disease courses in COVID-19 patients vary widely. Prediction of disease severity on initial diagnosis would aid appropriate therapy, but few studies include data from initial diagnosis. Objective.— To develop predictive models of…
View article: Genomic surveillance of SARS-CoV-2 during the first year of the pandemic in the Bronx enabled clinical and epidemiological inference
Genomic surveillance of SARS-CoV-2 during the first year of the pandemic in the Bronx enabled clinical and epidemiological inference Open
The Bronx was an early epicenter of the COVID-19 pandemic in the United States. We conducted temporal genomic surveillance of 104 SARS-CoV-2 genomes across the Bronx from March to October 2020. Although the local structure of SARS-CoV-2 li…
View article: SNP and Phylogenetic Characterization of Low Viral Load SARS-CoV-2 Specimens by Target Enrichment
SNP and Phylogenetic Characterization of Low Viral Load SARS-CoV-2 Specimens by Target Enrichment Open
Background: Surveillance of SARS-CoV-2 across the globe has enabled detection of new variants and informed the public health response. With highly sensitive methods like qPCR widely adopted for diagnosis, the ability to sequence and charac…
View article: 313. Host Protein Biomarkers Predicting Severity of Lung Damage due to COVID-19
313. Host Protein Biomarkers Predicting Severity of Lung Damage due to COVID-19 Open
Background Biomarkers to predict the severity of lung damage due to COVID-19 are urgently needed to inform management and treatment decisions. Our objective was to investigate the predictive value of host proteins for worsening respiratory…
View article: Single-Dilution COVID-19 Antibody Test with Qualitative and Quantitative Readouts
Single-Dilution COVID-19 Antibody Test with Qualitative and Quantitative Readouts Open
Serological surveillance has become an important public health tool during the COVID-19 pandemic. Detection of protective antibodies and seroconversion after SARS-CoV-2 infection or vaccination can help guide patient care plans and public …
View article: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Qualitative Immunoglobulin G Assays: The Value of Numeric Reporting
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Qualitative Immunoglobulin G Assays: The Value of Numeric Reporting Open
Context.— Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) testing is used for serosurveillance and will be important to evaluate vaccination status. Given the urgency to release coronavirus disease 2019 …
View article: Approaching the Interpretation of Discordances in SARS-CoV-2 Testing
Approaching the Interpretation of Discordances in SARS-CoV-2 Testing Open
The coronavirus disease 2019 pandemic has upended life throughout the globe. Appropriate emphasis has been placed on developing effective therapies and vaccines to curb the pandemic. While awaiting such countermeasures, mitigation efforts …
View article: Genomic surveillance of SARS-CoV-2 during the first year of the pandemic in the Bronx enabled clinical and epidemiological inference
Genomic surveillance of SARS-CoV-2 during the first year of the pandemic in the Bronx enabled clinical and epidemiological inference Open
The Bronx was an early epicenter of the COVID-19 pandemic in the USA. We conducted temporal genomic surveillance of SARS-CoV-2 genomes across the Bronx from March-October 2020. Although the local structure of SARS-CoV-2 lineages mirrored t…
View article: Treatment of Severe COVID-19 with Convalescent Plasma in Bronx, NYC
Treatment of Severe COVID-19 with Convalescent Plasma in Bronx, NYC Open
Convalescent plasma with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) antibodies (CCP) may hold promise as a treatment for coronavirus disease 2019 (COVID-19). We compared the mortality and clinical outcome of patients with …
View article: Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC
Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC Open
Convalescent plasma with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) antibodies (CCP) may hold promise as treatment for Coronavirus Disease 2019 (COVID-19). We compared the mortality and clinical outcome of patients with CO…
View article: Extended storage of SARS-CoV-2 nasopharyngeal swabs does not negatively impact results of molecular-based testing across three clinical platforms
Extended storage of SARS-CoV-2 nasopharyngeal swabs does not negatively impact results of molecular-based testing across three clinical platforms Open
With the global outbreak of COVID-19, the demand for testing rapidly increased and quickly exceeded the testing capacities of many laboratories. Clinical tests which receive CE (Conformité Européenne) and Food and Drug Administration (FDA)…
View article: False Negative PCR Tests for SARS-COV-2 – the Elephant in the Room
False Negative PCR Tests for SARS-COV-2 – the Elephant in the Room Open
Without criterion standards, clinicians have often been at a loss to interpret the meaningfulness of negative SARS-COV2 PCR testing in admitted patients. We provide a compelling epidemiologic analysis to ascertain an estimated false negati…
View article: Development, clinical translation, and utility of a COVID-19 antibody test with qualitative and quantitative readouts
Development, clinical translation, and utility of a COVID-19 antibody test with qualitative and quantitative readouts Open
The COVID-19 global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to place an immense burden on societies and healthcare systems. A key component of COVID-19 control efforts is serologic testing …
View article: Performance Characteristics of a High-Throughput Automated Transcription-Mediated Amplification Test for SARS-CoV-2 Detection
Performance Characteristics of a High-Throughput Automated Transcription-Mediated Amplification Test for SARS-CoV-2 Detection Open
The COVID-19 pandemic caused by the new SARS-CoV-2 coronavirus has imposed severe challenges on laboratories in their effort to achieve sufficient diagnostic testing capability for identifying infected individuals. In this study, we report…
View article: Performance characteristics of a high throughput automated transcription mediated amplification test for SARS-CoV-2 detection
Performance characteristics of a high throughput automated transcription mediated amplification test for SARS-CoV-2 detection Open
The COVID-19 pandemic caused by the new SARS-CoV-2 coronavirus has imposed severe challenges on laboratories in their effort to achieve sufficient diagnostic testing capability for identifying infected individuals. In this study we report …
View article: Utility of Stool PCR for the Diagnosis of COVID-19: Comparison of Two Commercial Platforms
Utility of Stool PCR for the Diagnosis of COVID-19: Comparison of Two Commercial Platforms Open
The ability to detect SARS-CoV-2 in the upper respiratory tract ceases after 2 to 3 weeks post-symptom-onset in most patients. In contrast, SARS-CoV-2 can be detected in the stool of some patients for greater than 4 weeks, suggesting that …
View article: Extended Storage of SARS-CoV2 Nasopharyngeal Swabs Does Not Negatively Impact Results of Molecular-Based Testing
Extended Storage of SARS-CoV2 Nasopharyngeal Swabs Does Not Negatively Impact Results of Molecular-Based Testing Open
With the global outbreak of the novel coronavirus disease 2019, the demand for testing rapidly increased and quickly exceeded the testing capacities for many laboratories. Clinical tests which receive CE and FDA authorizations cannot alway…
View article: SurePath Specimens Versus ThinPrep Specimen Types on the COBAS 4800 Platform: High-Risk HPV Status and Cytology Correlation in an Ethnically Diverse Bronx Population
SurePath Specimens Versus ThinPrep Specimen Types on the COBAS 4800 Platform: High-Risk HPV Status and Cytology Correlation in an Ethnically Diverse Bronx Population Open
Cobas 4800 HPV testing of SP-collected specimen concentrates yields comparable results to TP-collected specimen concentrates. Based on the limited data that we derived, SP collection may be a more favorable methodology than TP collection f…