Amy Goodwin
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View article: In Vivo Glx Measurements From GABA‐Edited HERMES at 3 T Are Not Consistent With Those From Short‐TE PRESS Across Scanners, Brain Regions, Diagnostic and Age Groups
In Vivo Glx Measurements From GABA‐Edited HERMES at 3 T Are Not Consistent With Those From Short‐TE PRESS Across Scanners, Brain Regions, Diagnostic and Age Groups Open
1H‐Magnetic resonance spectroscopy (1H‐MRS) is a noninvasive technique for quantifying brain metabolites, including glutamate, glutathione (GSH), and γ‐aminobutyric acid (GABA), which are essential for brain function and implicated in vari…
View article: Data sharing in child and adolescent psychiatry research: Key challenges (and some potential solutions)
Data sharing in child and adolescent psychiatry research: Key challenges (and some potential solutions) Open
Background The field of biomedical research is entering a new era, in which public data sharing is increasingly the norm. There are many advantages of embracing data sharing initiatives, including tackling the replication crisis through en…
View article: Family history of ADHD associates with stronger problem‐solving skills amongst 2‐ to 3‐year‐olds
Family history of ADHD associates with stronger problem‐solving skills amongst 2‐ to 3‐year‐olds Open
Background Attention‐Deficit/Hyperactivity Disorder (ADHD) is linked to strengths in creative problem‐solving amongst school‐aged children and adults. In contrast, autism (which frequently co‐occurs with ADHD) is associated with lower gene…
View article: Simple Executive Function as an endophenotype of autism-ADHD, and differing associations between simple versus complex Executive Functions and autism/ADHD traits
Simple Executive Function as an endophenotype of autism-ADHD, and differing associations between simple versus complex Executive Functions and autism/ADHD traits Open
Autism and ADHD are associated with difficulties with Executive Functions (EFs), but the prevalence and nature of these difficulties in early development is not well understood. In this longitudinal study, 107 children with a family histor…
View article: Simple Executive Function as an endophenotype of autism-ADHD, and differing associations between simple versus complex Executive Functions and autism/ADHD traits
Simple Executive Function as an endophenotype of autism-ADHD, and differing associations between simple versus complex Executive Functions and autism/ADHD traits Open
Executive Functions (EFs) enable us to control attention and behaviour in pursuit of a goal. In this longitudinal study, 107 children with a family history of autism and/or ADHD (FH-autism/ADHD), and 24 children with no FH-autism/ADHD comp…
View article: <i>Uh</i> and <i>um</i> in autism: The case of hesitation marker usage in Dutch-speaking autistic preschoolers
<i>Uh</i> and <i>um</i> in autism: The case of hesitation marker usage in Dutch-speaking autistic preschoolers Open
English-speaking autistic children use the hesitation marker um less often than non-autistic children but use uh at a similar rate. It is unclear why this is the case. We employed a sample of Dutch-speaking children from the Preschool Brai…
View article: Cortical markers of excitation/inhibition balance are associated with sensory responsivity from infancy in longitudinal cohorts enriched for autism and ADHD
Cortical markers of excitation/inhibition balance are associated with sensory responsivity from infancy in longitudinal cohorts enriched for autism and ADHD Open
Autism and ADHD are characterised by atypical sensory responsivity, and this may be driven by alterations in the balance of cortical excitation to inhibition (E/I). Studies in early development are required to establish the primary of effe…
View article: From the lab to the field: acceptability of using electroencephalography with Indian preschool children
From the lab to the field: acceptability of using electroencephalography with Indian preschool children Open
Background: Measurement of social and cognitive brain development using electroencephalography (EEG) offers the potential for early identification of children with elevated risk of developmental delay. However, there have been no published…
View article: Cortical responses to social stimuli in infants at elevated likelihood of ASD and/or ADHD: A prospective cross-condition fNIRS study
Cortical responses to social stimuli in infants at elevated likelihood of ASD and/or ADHD: A prospective cross-condition fNIRS study Open
Autism spectrum disorders (ASD) and attention-deficit hyperactivity disorder (ADHD) are highly prevalent neurodevelopmental conditions that often co-occur and present both common and distinct neurodevelopmental profiles. Studying the devel…
View article: Parent attitudes towards data sharing in developmental science
Parent attitudes towards data sharing in developmental science Open
Data sharing in developmental science is increasingly encouraged, supported by funder and publisher mandates for open data access. Data sharing can accelerate the pace of discovery, link researchers with high quality analytic expertise to …
View article: Three year outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder
Three year outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder Open
Background Most research on early outcomes in infants with a family history (FH) of autism has focussed on categorically defined autism, although some have language and developmental delays. Less is known about outcomes in infants with a F…
View article: Infant Excitation/Inhibition Balance Interacts with Executive Attention to Predict Autistic Traits in Childhood
Infant Excitation/Inhibition Balance Interacts with Executive Attention to Predict Autistic Traits in Childhood Open
Background: Autism is proposed to be characterised by an atypical balance of cortical excitation and inhibition (E/I). However, most studies have examined E/I alterations in older autistic individuals, meaning that findings could in part r…
View article: From the lab to the field: acceptability of using electroencephalography with Indian preschool children
From the lab to the field: acceptability of using electroencephalography with Indian preschool children Open
Background: Measurement of social and cognitive brain development using electroencephalography (EEG) offers the potential for early identification of children with elevated risk of developmental delay. However, there have been no published…
View article: Altered theta–beta ratio in infancy associates with family history of ADHD and later ADHD‐relevant temperamental traits
Altered theta–beta ratio in infancy associates with family history of ADHD and later ADHD‐relevant temperamental traits Open
Background Uncovering the neural mechanisms that underlie symptoms of attention deficit hyperactivity disorder (ADHD) requires studying brain development prior to the emergence of behavioural difficulties. One new approach to this is prosp…
View article: Behavioural Measures of Infant Activity but Not Attention Associate with Later Preschool ADHD Traits
Behavioural Measures of Infant Activity but Not Attention Associate with Later Preschool ADHD Traits Open
Mapping infant neurocognitive differences that precede later ADHD-related behaviours is critical for designing early interventions. In this study, we investigated (1) group differences in a battery of measures assessing aspects of attentio…
View article: Infant EEG theta modulation predicts childhood intelligence
Infant EEG theta modulation predicts childhood intelligence Open
Intellectual functioning is a critical determinant of economic and personal productivity. Identifying early neural predictors of cognitive function in infancy will allow us to map the neurodevelopmental pathways that underpin individual di…