Amy Hackett
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View article: Phase I dose-escalation study of fractionated dose 177Lu-PSMA-617 for progressive metastatic castration resistant prostate cancer (mCRPC)
Phase I dose-escalation study of fractionated dose 177Lu-PSMA-617 for progressive metastatic castration resistant prostate cancer (mCRPC) Open
Background: PSMA is selectively overexpressed in advanced PC with upregulation by androgen receptor (AR) pathway dysregulation; limited expression in other organs. PC is radiosensitive with dose-response data. Dose-fractionation may allow …
View article: Antibody-Drug Conjugates in Bladder Cancer
Antibody-Drug Conjugates in Bladder Cancer Open
Urothelial carcinoma (UC) is characterized by expression of a plethora of cell surface antigens, thus offering opportunities for specific therapeutic targeting with use of antibody-drug conjugates (ADCs). ADCs are structured from two major…
View article: Lifelong neurogenesis in the cerebral ganglion of the Chinese mud snail,<i>Cipangopaludina chinensis</i>
Lifelong neurogenesis in the cerebral ganglion of the Chinese mud snail,<i>Cipangopaludina chinensis</i> Open
Introduction A small group of Gastropods possessing giant neurons have long been used to study a wide variety of fundamental neurophysiological phenomena. However, the majority of gastropods do not have large neurons but instead have large…