Albert Heim
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View article: An Epidemic of Respiratory and Ocular Infections Caused by the Reemergence of a Recombinant Human Adenovirus, the Novel Type HAdV‐B114 (P7H3F3)
An Epidemic of Respiratory and Ocular Infections Caused by the Reemergence of a Recombinant Human Adenovirus, the Novel Type HAdV‐B114 (P7H3F3) Open
Human adenoviruses of species B (HAdV‐B) can cause upper respiratory tract infections and conjunctivitis, but also severe lower respiratory tract infections (LRTI). Although HAdV‐associated LRTI are non‐notifiable in Germany, typing data o…
View article: Current Trends of Human Adenovirus Types Among Hospitalized Children—A Systematic Review
Current Trends of Human Adenovirus Types Among Hospitalized Children—A Systematic Review Open
Human adenoviruses (HAdVs) are pathogens causing different illnesses, particularly in pediatric and immunocompromised patients in developed countries. The clinical spectrum of HAdV-infections ranges from mild to severe, and the clinical pr…
View article: TIGIT expression on natural killer cell subsets is an early indicator of alleviating liver inflammation following bulevirtide treatment in chronic hepatitis D
TIGIT expression on natural killer cell subsets is an early indicator of alleviating liver inflammation following bulevirtide treatment in chronic hepatitis D Open
Background and Aims: Bulevirtide (BLV) is a novel and the only approved treatment option for patients with chronic hepatitis D (CHD). BLV alleviates liver inflammation early during treatment when only minor HDV RNA changes are observed. We…
View article: Inhibition of B cell receptor signaling induced by the human adenovirus species D E3/49K protein
Inhibition of B cell receptor signaling induced by the human adenovirus species D E3/49K protein Open
Introduction The early transcription unit 3 (E3) of human adenoviruses (HAdVs) encodes several immunoevasins, including the E3/49K protein, which is unique for species D of HAdVs. It is expressed as surface transmembrane protein and shed. …
View article: Closing the Diagnostic Gap in Encephalitis and Acute Disseminated Encephalomyelitis through Digital Case Classification and Viral Metagenomics
Closing the Diagnostic Gap in Encephalitis and Acute Disseminated Encephalomyelitis through Digital Case Classification and Viral Metagenomics Open
Encephalitis and acute disseminated encephalomyelitis (ADEM) are often caused or triggered by viruses—but the specific pathogen commonly remains unidentified in routine care. We explored the use of viral metagenomic next-generation sequenc…
View article: Fulminant Adenoviral-Induced Hepatitis in Immunosuppressed Patients
Fulminant Adenoviral-Induced Hepatitis in Immunosuppressed Patients Open
Human adenovirus (HAdV) can often lead to fulminant hepatitis in immunocompromised patients, mostly after reactivation of HAdV. Different risk factors, e.g., transplantation and chemotherapy, increase the risk of developing a HAdV hepatiti…
View article: High genetic stability of co-circulating human adenovirus type 31 lineages over 59 years
High genetic stability of co-circulating human adenovirus type 31 lineages over 59 years Open
Type 31 of human adenovirus species A (HAdV-A31) is a significant pathogen primarily associated with diarrhoea in children but also with life-threatening disseminated disease in allogeneic haematopoietic stem cell transplant (HSCT) recipie…
View article: Molecular phylogeny of human adenovirus type 41 lineages
Molecular phylogeny of human adenovirus type 41 lineages Open
Type 41 of human adenovirus species F (HAdV-F41) is a frequent aetiology of gastroenteritis in children, and nosocomial as well as kindergarten outbreaks have been frequently described. In contrast to other HAdV types, HAdV-F41 was not ass…
View article: Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients
Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients Open
Background Respiratory syncytial virus (RSV) causes community-acquired respiratory tract infections during winter. However, outbreaks in hospitals also occur repeatedly. In particular, patients with hematologic malignancies are at an incre…
View article: Molecular Phylogeny of human adenovirus type 41 lineages
Molecular Phylogeny of human adenovirus type 41 lineages Open
Type 41 of human adenovirus species F (HAdV-F41) is a frequent aetiology of gastroenteritis in children, and nosocomial as well as kindergarten outbreaks have been frequently described. In contrast to other HAdV types, HAdV-F41 was not ass…
View article: Additional file 5 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients
Additional file 5 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients Open
Additional file 5. Summary of short read sequencing results
View article: Additional file 1 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients
Additional file 1 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients Open
Additional file 1. GenBank accession numbers of RSV-A genomes applied in probe design
View article: Additional file 4 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients
Additional file 4 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients Open
Additional file 4. Fasta files of all RSV capture probes
View article: Additional file 2 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients
Additional file 2 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients Open
Additional file 2. GenBank accession numbers of RSV-B genomes applied in probe design
View article: Additional file 7 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients
Additional file 7 of Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients Open
Additional file 7. Overview of SNPs of all RSV sequences obtained
View article: Human cytomegalovirus multiple-strain infections and viral population diversity in haematopoietic stem cell transplant recipients analysed by high-throughput sequencing
Human cytomegalovirus multiple-strain infections and viral population diversity in haematopoietic stem cell transplant recipients analysed by high-throughput sequencing Open
Human cytomegalovirus (HCMV) is an important opportunistic pathogen in allogeneic haematopoietic stem cell transplant (HSCT) recipients. High-throughput sequencing of target-enriched libraries was performed to characterise the diversity of…
View article: Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2 with grinch
Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2 with grinch Open
Late in 2020, two genetically-distinct clusters of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with mutations of biological concern were reported, one in the United Kingdom and one in South Africa. Using a combination of d…
View article: Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2
Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2 Open
Late in 2020, two genetically-distinct clusters of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with mutations of biological concern were reported, one in the United Kingdom and one in South Africa. Using a combination of d…
View article: The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral <i>UL4</i> / <i>UL5</i> Transcripts
The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral <i>UL4</i> / <i>UL5</i> Transcripts Open
Viral infections have a large impact on society, leading to major human and economic losses and even global instability. So far, many viral infections, including human cytomegalovirus (HCMV) infection, are treated with a small repertoire o…
View article: Posttransplantation MRD monitoring in patients with AML by next-generation sequencing using DTA and non-DTA mutations
Posttransplantation MRD monitoring in patients with AML by next-generation sequencing using DTA and non-DTA mutations Open
Next-generation sequencing (NGS)-based measurable residual disease (MRD) monitoring in patients with acute myeloid leukemia (AML) is widely applicable and prognostic prior to allogeneic hematopoietic cell transplantation (alloHCT). We eval…
View article: The zinc finger antiviral protein ZAP destabilises viral transcripts and restricts human cytomegalovirus
The zinc finger antiviral protein ZAP destabilises viral transcripts and restricts human cytomegalovirus Open
Interferon-stimulated gene products (ISGs) play a crucial role in early infection control. The ISG zinc finger CCCH-type antiviral protein 1 (ZAP/ZC3HAV1) antagonises several RNA viruses by binding to CG-rich RNA sequences, whereas its eff…
View article: Fully automated detection and differentiation of pandemic and endemic coronaviruses (NL63, 229E, HKU1, OC43 and SARS-CoV-2) on the Hologic Panther Fusion
Fully automated detection and differentiation of pandemic and endemic coronaviruses (NL63, 229E, HKU1, OC43 and SARS-CoV-2) on the Hologic Panther Fusion Open
The Hologic Panther Fusion (PF) platform provides fully automated CE marked diagnostics for respiratory viruses, including recently SARS-coronavirus 2 by a transcription mediated amplification (TMA) assay, but not for the endemic human cor…
View article: High-Throughput Cloning and Characterization of Emerging Adenovirus Types 70, 73, 74, and 75
High-Throughput Cloning and Characterization of Emerging Adenovirus Types 70, 73, 74, and 75 Open
Recently an increasing number of new adenovirus types associated with type-dependent pathogenicity have been identified. However, identification of these clinical isolates represents the very first step to characterize novel pathogens. For…
View article: Whole-Genome Approach to Assessing Human Cytomegalovirus Dynamics in Transplant Patients Undergoing Antiviral Therapy
Whole-Genome Approach to Assessing Human Cytomegalovirus Dynamics in Transplant Patients Undergoing Antiviral Therapy Open
Human cytomegalovirus (HCMV) is the most frequent cause of opportunistic viral infection following transplantation. Viral factors of potential clinical importance include the selection of mutants resistant to antiviral drugs and the occurr…