Amy K. Bei
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View article: Oxytocin Deficiency in Childhood and Adolescence: Clinical Features, Diagnostic Challenges and Therapeutic Perspectives
Oxytocin Deficiency in Childhood and Adolescence: Clinical Features, Diagnostic Challenges and Therapeutic Perspectives Open
Oxytocin (OXT), traditionally linked to reproductive physiology, is now recognized as an important regulator of metabolic, skeletal, and socio-emotional processes. In children and adolescents, oxytocin deficiency (OXT-D) represents a signi…
View article: <i>Anopheles</i> mosquitoes exposed to long-acting antimalarials via drug-spiked bloodmeal absorb drug but do not suffer fitness costs
<i>Anopheles</i> mosquitoes exposed to long-acting antimalarials via drug-spiked bloodmeal absorb drug but do not suffer fitness costs Open
The World Health Organization’s recommendations regarding the use of antimalarials for the prevention of malaria in endemic areas have greatly expanded, allowing more flexibility in the demographic groups and regions where chemoprevention …
View article: Evaluating the potential of cross-species neutralization of anti-PfCyRPA and anti-PfRIPR Monoclonal Antibodies
Evaluating the potential of cross-species neutralization of anti-PfCyRPA and anti-PfRIPR Monoclonal Antibodies Open
PfCyRPA and PfRIPR are promising next-generation malaria blood-stage vaccine candidate antigens that play an essential role in erythrocyte invasion of Plasmodium falciparum . CyRPA and RIPR orthologs are present in all human-infecting Plas…
View article: Secondary Adrenal Insufficiency and Iatrogenic Cushing's Syndrome in a 13-Year-Old Male With Vogt-Koyanagi-Harada Disease: A Case Report
Secondary Adrenal Insufficiency and Iatrogenic Cushing's Syndrome in a 13-Year-Old Male With Vogt-Koyanagi-Harada Disease: A Case Report Open
Vogt-Koyanagi-Harada disease (VKH) is a rare autoimmune disorder, especially in children, requiring long-term corticosteroids. We report a 13-year-old male with VKH who developed iatrogenic Cushing's syndrome and secondary adrenal insuffic…
View article: Genetic Diversity of the Malaria Vaccine Candidate PfRIPR in a High Transmission Region of Senegal
Genetic Diversity of the Malaria Vaccine Candidate PfRIPR in a High Transmission Region of Senegal Open
Summary RH5-Interacting Protein (RIPR) is essential for the invasion of Plasmodium into host red blood cells and is currently being studied as a novel malaria vaccine candidate in Phase 1a clinical trials. To study the genetic diversity of…
View article: Idiopathic Short Stature in the Genomic Era: Integrating Auxology, Endocrinology, and Emerging Genetic Insights
Idiopathic Short Stature in the Genomic Era: Integrating Auxology, Endocrinology, and Emerging Genetic Insights Open
Idiopathic short stature (ISS) represents one of the most frequent yet enigmatic conditions in pediatric endocrinology. Traditionally defined by auxological parameters in the absence of identifiable causes, ISS has long served as a diagnos…
View article: Temporal changes in pneumococcal carriage among childcare-attending children during the COVID-19 pandemic in the Greater New Haven Area, USA
Temporal changes in pneumococcal carriage among childcare-attending children during the COVID-19 pandemic in the Greater New Haven Area, USA Open
View article: Precocious Puberty and Benign Variants in Female Children: Etiology, Diagnostic Challenges, and Clinical Management
Precocious Puberty and Benign Variants in Female Children: Etiology, Diagnostic Challenges, and Clinical Management Open
Precocious puberty, defined as the onset of secondary sexual characteristics before age 8 in girls, presents a diagnostic challenge in distinguishing between normal variants and pathological conditions requiring intervention. Central preco…
View article: Household practices and infrastructure associated with high Plasmodium falciparum infection rates among children under five years old in Northern Uganda
Household practices and infrastructure associated with high Plasmodium falciparum infection rates among children under five years old in Northern Uganda Open
View article: Temporal changes in pneumococcal carriage among childcare-attending children during the COVID-19 pandemic in the Greater New Haven Area, USA
Temporal changes in pneumococcal carriage among childcare-attending children during the COVID-19 pandemic in the Greater New Haven Area, USA Open
Introduction Non-pharmaceutical interventions (NPIs), which aimed to reduce transmission of SARS-CoV-2, also reduced the circulation of other respiratory pathogens. However, it remains unclear to what extent NPIs disrupted pneumococcal col…
View article: 95 Assessing genetic diversity of the Pfs25 vaccine candidate: Implications for malaria transmission-blocking vaccine in Africa
95 Assessing genetic diversity of the Pfs25 vaccine candidate: Implications for malaria transmission-blocking vaccine in Africa Open
Objectives/Goals: Transmission-blocking vaccines hold promise for malaria elimination by reducing community transmission. But a major challenge that limits the development of efficacious vaccines is the vast parasite’s genetic diversity. T…
View article: Two Mosquito Salivary Antigens Demonstrate Promise as Biomarkers of Recent Exposure to <i>Plasmodium falciparum–</i>Infected Mosquito Bites
Two Mosquito Salivary Antigens Demonstrate Promise as Biomarkers of Recent Exposure to <i>Plasmodium falciparum–</i>Infected Mosquito Bites Open
Background Measuring malaria transmission intensity using the traditional entomological inoculation rate is difficult. Antibody responses to mosquito salivary proteins like SG6 have been used as biomarkers of exposure to Anopheles mosquito…
View article: Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against P. falciparum clinical isolates
Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against P. falciparum clinical isolates Open
Vaccines to the Plasmodium falciparum reticulocyte binding-like protein homologue 5 (PfRH5) target the blood-stage of the parasite life cycle. PfRH5 has the potential to trigger the production of strain-transcendent antibodies and has prov…
View article: Genetic diversity in the Plasmodium falciparum next-generation blood stage vaccine candidate antigen PfCyRPA in Senegal
Genetic diversity in the Plasmodium falciparum next-generation blood stage vaccine candidate antigen PfCyRPA in Senegal Open
The Plasmodium falciparum cysteine-rich protective antigen (PfCyRPA) is a promising target as a next-generation blood-stage malaria vaccine and together with PCRCR complex members, the reticulocyte binding-like homologous protein 5 (PfRh5)…
View article: A kalihinol analog disrupts apicoplast function and vesicular trafficking in <i>P. falciparum</i> malaria
A kalihinol analog disrupts apicoplast function and vesicular trafficking in <i>P. falciparum</i> malaria Open
We report the discovery of MED6-189, an analog of the kalihinol family of isocyanoterpene natural products that is effective against drug-sensitive and drug-resistant Plasmodium falciparum strains, blocking both asexual replication and sex…
View article: Understanding the significance of oxygen tension on the biology of Plasmodium falciparum blood stages: From the human body to the laboratory
Understanding the significance of oxygen tension on the biology of Plasmodium falciparum blood stages: From the human body to the laboratory Open
Plasmodium falciparum undergoes sequestration within deep tissues of the human body, spanning multiple organ systems with differing oxygen (O 2 ) concentrations. The parasite is exposed to an even greater range of O 2 concentrations as it …
View article: Improved species assignments across the entire Anopheles genus using targeted sequencing
Improved species assignments across the entire Anopheles genus using targeted sequencing Open
Accurate species identification of the mosquitoes in the genus Anopheles is of crucial importance to implement malaria control measures and monitor their effectiveness. We use a previously developed amplicon panel (ANOSPP) that retrieves s…
View article: A low-cost culture- and DNA extraction-free method for the molecular detection of pneumococcal carriage in saliva
A low-cost culture- and DNA extraction-free method for the molecular detection of pneumococcal carriage in saliva Open
Molecular methods have improved the sensitivity of the detection of pneumococcal carriage in saliva. However, they typically require sample culture enrichment and nucleic acid extraction prior to performing the detection assay and may limi…
View article: Two decades of molecular surveillance in Senegal reveal rapid changes in known drug resistance mutations over time
Two decades of molecular surveillance in Senegal reveal rapid changes in known drug resistance mutations over time Open
Background Drug resistance in Plasmodium falciparum is a major threat to malaria control efforts. Pathogen genomic surveillance could be invaluable for monitoring current and emerging parasite drug resistance. Methods Data from two decades…
View article: Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against<i>P. falciparum</i>clinical isolates
Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against<i>P. falciparum</i>clinical isolates Open
Vaccines to the Plasmodium falciparum reticulocyte binding-like protein homologue 5 (PfRH5) target the blood-stage of the parasite life cycle. PfRH5 has the potential to trigger the production of strain-transcendent antibodies and has prov…
View article: Two mosquito salivary antigens demonstrate promise as biomarkers of recent exposure to <i>P. falciparum</i> infected mosquito bites
Two mosquito salivary antigens demonstrate promise as biomarkers of recent exposure to <i>P. falciparum</i> infected mosquito bites Open
Background Measuring malaria transmission intensity using the traditional entomological inoculation rate is difficult. Antibody responses to mosquito salivary proteins such as SG6 have previously been used as biomarkers of exposure to Anop…
View article: A low-cost culture- and DNA extraction-free method for the molecular detection of pneumococcal carriage in saliva
A low-cost culture- and DNA extraction-free method for the molecular detection of pneumococcal carriage in saliva Open
Background Molecular methods have improved the sensitivity of detection of pneumococcal carriage in saliva. However, they typically require sample culture-enrichment and nucleic acid extraction, prior to performing the detection assay. The…
View article: Ex vivo susceptibility and molecular signature assessment of antimalarial-based combination therapies (ACT) partner drugs resistance in Senegal
Ex vivo susceptibility and molecular signature assessment of antimalarial-based combination therapies (ACT) partner drugs resistance in Senegal Open
Background Over the last decades, Plasmodium falciparum – the main causative agent of malaria – has constantly developed resistance to antimalarial drugs such as chloroquine, sulfadoxine-pyrimethamine or artemisinin derivatives. Therefore,…
View article: Ex vivo RSA and pfkelch13 targeted-amplicon deep sequencing reveal parasites susceptibility to artemisinin in Senegal, 2017
Ex vivo RSA and pfkelch13 targeted-amplicon deep sequencing reveal parasites susceptibility to artemisinin in Senegal, 2017 Open
Background Malaria control is highly dependent on the effectiveness of artemisinin-based combination therapy (ACT), the current frontline malaria curative treatment. Unfortunately, the emergence and spread of parasites resistant to artemis…
View article: Identification of an in vitro artemisinin-resistant Plasmodium falciparum kelch13 R515K mutant parasite in Senegal
Identification of an in vitro artemisinin-resistant Plasmodium falciparum kelch13 R515K mutant parasite in Senegal Open
The emergence of artemisinin partial resistance (ART-r) in Plasmodium falciparum malaria parasites has substantially compromised the efficacy of antimalarial treatments across southeast Asia (SE Asia). The spread of ART-r within the Africa…
View article: Two decades of molecular surveillance in Senegal reveal changes in known drug resistance mutations associated with historical drug use and seasonal malaria chemoprevention
Two decades of molecular surveillance in Senegal reveal changes in known drug resistance mutations associated with historical drug use and seasonal malaria chemoprevention Open
Drug resistance in Plasmodium falciparum is a major threat to malaria control efforts. We analyzed data from two decades (2000-2020) of continuous molecular surveillance of P. falciparum parasite strains in Senegal to determine how histori…
View article: Tracking antimalarial drug resistance using mosquito blood meals: a cross-sectional study
Tracking antimalarial drug resistance using mosquito blood meals: a cross-sectional study Open
For the French translation of the abstract see Supplementary Materials section.
View article: Ex vivo RSA and Pfkelch13 targeted-amplicon deep sequencing reveal parasites susceptibility to artemisinin in Senegal, 2017
Ex vivo RSA and Pfkelch13 targeted-amplicon deep sequencing reveal parasites susceptibility to artemisinin in Senegal, 2017 Open
Introduction. Malaria control is highly dependent on the effectiveness of artemisinin-based combination therapies (ACTs), the current frontline malaria curative treatments. Unfortunately, the emergence and spread of parasites resistant to …
View article: Routine saliva testing for SARS-CoV-2 in children: Methods for partnering with community childcare centers
Routine saliva testing for SARS-CoV-2 in children: Methods for partnering with community childcare centers Open
While considerable attention was placed on SARS-CoV-2 testing and surveillance programs in the K-12 setting, younger age groups in childcare centers were largely overlooked. Childcare facilities are vital to communities, allowing parents/g…
View article: Plasmodium infection is associated with cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein
Plasmodium infection is associated with cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein Open