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Profiling the genomic landscape and evolutionary history of polyploid giant cancer cells in undifferentiated pleomorphic sarcomas Open

Amy L. Bowes, Sara Waise, Tom Lesluyes, Thomas Butters, Christie English , et al. · 2025

Polyploid giant cancer cells (PGCCs), characterised by multinucleation and atypical nuclear morphology, are a common feature of undifferentiated pleomorphic sarcomas. While PGCCs may be a critical substrate for cancer evolution, their form…

Cooperative and antagonistic interactions between sub-clones favour the co-existence of multiple resistance mechanisms in melanoma Open

Karin Schlegelmilch, Viola Hollek, Steven Hooper, Giovanni Giangreco, Sasha Bailey , et al. · 2025

Resistance to targeted therapies develops in the majority of patients, with numerous different mechanisms having been documented. This is frequently linked to intra-tumour heterogeneity and cancer cells transitioning into different states.…

Supplementary Table S1 from The History of Chromosomal Instability in Genome-Doubled Tumors Open

Toby M. Baker, Siqi Lai, Andrew R. Lynch, Tom Lesluyes, Haixi Yan , et al. · 2024

Table S1 shows the number of possible routes for different copy numbers states.

Supplementary Figures from The History of Chromosomal Instability in Genome-Doubled Tumors Open

Toby M. Baker, Siqi Lai, Andrew R. Lynch, Tom Lesluyes, Haixi Yan , et al. · 2024

Supplementary Figures S1 to S52 S1 WGD frequencies across cancer types and stage. S2 Effect of WGD constraint on timing accuracy. S3 Measuring timing accuracy on simulated data. S4-7 Measuring timing accuracy on simulated data by copy numb…

Supplementary Methods from The History of Chromosomal Instability in Genome-Doubled Tumors Open

Toby M. Baker, Siqi Lai, Andrew R. Lynch, Tom Lesluyes, Haixi Yan , et al. · 2024

Supplementary methods, including full description of the GRITIC method

Data from The History of Chromosomal Instability in Genome-Doubled Tumors Open

Toby M. Baker, Siqi Lai, Andrew R. Lynch, Tom Lesluyes, Haixi Yan , et al. · 2024

Tumors frequently display high chromosomal instability and contain multiple copies of genomic regions. Here, we describe Gain Route Identification and Timing In Cancer (GRITIC), a generic method for timing genomic gains leading to complex …

The History of Chromosomal Instability in Genome-Doubled Tumors Open

Toby M. Baker, Siqi Lai, Andrew R. Lynch, Tom Lesluyes, Haixi Yan , et al. · 2024

Tumors frequently display high chromosomal instability and contain multiple copies of genomic regions. Here, we describe Gain Route Identification and Timing In Cancer (GRITIC), a generic method for timing genomic gains leading to complex …

The history of chromosomal instability in genome doubled tumors Open

Toby M. Baker, Siqi Lai, Tom Lesluyes, Haixi Yan, Annelien Verfaillie , et al. · 2023

Tumors frequently display high chromosomal instability (CIN) and contain multiple copies of genomic regions. Here, we describe GRITIC, a generic method for timing genomic gains leading to complex copy number states, using single-sample bul…

Signatures of copy number alterations in human cancer Open

Christopher D. Steele, Ammal Abbasi, S. M. Ashiqul Islam, Amy L. Bowes, Azhar Khandekar , et al. · 2022

Leveraging single‐cell sequencing to unravel intratumour heterogeneity and tumour evolution in human cancers Open

Amy L. Bowes, Maxime Tarabichi, Nischalan Pillay, Peter Van Loo · 2022

Intratumour heterogeneity (ITH) and tumour evolution are well‐documented phenomena in human cancers. While the advent of next‐generation sequencing technologies has facilitated the large‐scale capture of genomic data, the field of single‐c…

Docosahexaenoic acid reduces microglia phagocytic activity via miR-124 and induces neuroprotection in rodent models of spinal cord contusion injury Open

Ping K. Yip, Amy L. Bowes, Jodie C.E. Hall, Miguel Ángel Burguillos, Ting Hin Richard Ip , et al. · 2019

Microglia are activated after spinal cord injury (SCI), but their phagocytic mechanisms and link to neuroprotection remain incompletely characterized. Docosahexaenoic acid (DHA) has been shown to have significant neuroprotective effects af…

Indirect Targeting of Subthalamic Deep Brain Stimulation Guided by Stereotactic Computed Tomography and Microelectrode Recordings in Patients With Parkinson’s Disease Open

Po‐Hsun Tu, Zhuo‐Hao Liu, Chiung Chu Chen, Wey Yil Lin, Amy L. Bowes , et al. · 2018

Objective: Magnetic resonance imaging fusion techniques guided by frame-based stereotactic computed tomography and microelectrode recordings are widely used to target the subthalamic nucleus. However, MRI is not always available. Th…

Neuroendoscopic surgery in children: does age at intervention influence safety and efficacy? A single-center experience Open

Amy L. Bowes, Josh King‐Robson, William Dawes, Greg James, Kristian Aquilina · 2017

OBJECTIVE The aim of this study was to review the safety of pediatric intraventricular endoscopy across separate age groups and to determine whether intraventricular endoscopy is associated with an increased risk of complications or reduce…

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