Amy L. Kiskaddon
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View article: Cytomegalovirus Breakthrough in Pediatric Cardiac Transplant Recipients Receiving Weight-Based Dosing Valganciclovir Prophylaxis
Cytomegalovirus Breakthrough in Pediatric Cardiac Transplant Recipients Receiving Weight-Based Dosing Valganciclovir Prophylaxis Open
OBJECTIVE Valganciclovir is an antiviral used to prevent CMV infection. The optimal dosing strategy remains uncertain as manufacturer and weight-based dosing strategies exist. This study aims to define the risk of CMV breakthrough using a …
View article: Dosing of intravenous alprostadil in neonates with ductal-dependent CHD
Dosing of intravenous alprostadil in neonates with ductal-dependent CHD Open
Introduction: Neonates with ductal-dependent CHD rely on the patency of the ductus arteriosus to maintain circulation. Alprostadil is utilised to maintain ductal patency, although optimal dosing has not been determined. This study aims to …
View article: Pulmonary Hypertension Outcomes After Closure of Atrial Septal Defect in Infants With Developmental Lung Disease
Pulmonary Hypertension Outcomes After Closure of Atrial Septal Defect in Infants With Developmental Lung Disease Open
Pulmonary hypertension (PHTN) in infants with developmental lung disease, such as bronchopulmonary dysplasia (BPD), chronic lung disease of infancy (CLD), or congenital diaphragmatic hernia (CDH), can be exacerbated by atrial septal shunts…
View article: Caudal Anaesthesia: clonidine and morphine dosing and outcomes in paediatric cardiac surgery
Caudal Anaesthesia: clonidine and morphine dosing and outcomes in paediatric cardiac surgery Open
We describe caudal analgesia agent, dose, reported adverse events, and outcomes in a single-centre, retrospective cohort study of 200 patients undergoing cardiac surgery from October 2020 to April 2023. Median (interquartile range) doses o…
View article: Arterial thromboembolism, antithrombotic therapy, and risk of recurrent thromboembolism in children with CHD undergoing cardiac surgery
Arterial thromboembolism, antithrombotic therapy, and risk of recurrent thromboembolism in children with CHD undergoing cardiac surgery Open
Introduction: Data on arterial thromboembolism in children undergoing cardiac surgery are limited. We sought to characterise, and estimate rates of, incident and recurrent arterial thromboembolism, and describe antithrombotic therapies for…
View article: Forty‐eight‐hour cold‐stored whole blood in paediatric cardiac surgery: Implications for haemostasis and blood donor exposures
Forty‐eight‐hour cold‐stored whole blood in paediatric cardiac surgery: Implications for haemostasis and blood donor exposures Open
Background and Objectives Cold‐stored whole blood (CS‐WB) in paediatric cardiac surgery is making a resurgence, given its identified benefits compared to conventional blood component therapy (CT). Study Design and Methods A single‐centre r…
View article: Frequency, characteristics, antithrombotic therapies, and outcomes of thromboembolism in paediatric patients with CHD undergoing cardiac surgery: a single centre retrospective study
Frequency, characteristics, antithrombotic therapies, and outcomes of thromboembolism in paediatric patients with CHD undergoing cardiac surgery: a single centre retrospective study Open
Introduction: Thromboembolism is a complication in paediatric patients with CHD requiring cardiac surgery. Previous research has focused on post-operative thromboembolism. This study aimed to describe thromboembolism frequency before or af…
View article: Ketorolac Dosing and Outcomes in Neonates Following Congenital Heart Surgery: A Retrospective Analysis
Ketorolac Dosing and Outcomes in Neonates Following Congenital Heart Surgery: A Retrospective Analysis Open
BACKGROUND: Pain management is essential for postoperative surgery. Given the association of opioids with adverse outcomes, interest in the use of nonopioid analgesics, such as ketorolac, has increased. Published data on use in neonates ar…
View article: Tadalafil in Neonates and Infants With Pulmonary Hypertension Secondary to Bronchopulmonary Dysplasia
Tadalafil in Neonates and Infants With Pulmonary Hypertension Secondary to Bronchopulmonary Dysplasia Open
OBJECTIVES The primary outcome of this study was to describe the dosing regimen of tadalafil in neonates and infants diagnosed with pulmonary hypertension (PH) secondary to bronchopulmonary dysplasia (BPD). Secondary outcomes included tole…
View article: Ketorolac in neonates and infants following congenital heart surgery: a retrospective review
Ketorolac in neonates and infants following congenital heart surgery: a retrospective review Open
Introduction: Pain management is essential in the immediate post-surgical period. We sought to describe the ketorolac dose regimen in neonates and infants following cardiac surgery. Secondary outcomes included renal dysfunction, bleeding, …
View article: Incidence and Timing of Thromboembolism in Pediatric Patients with Congenital Heart Disease Undergoing Cardiac Surgery: A Single Center Retrospective Study
Incidence and Timing of Thromboembolism in Pediatric Patients with Congenital Heart Disease Undergoing Cardiac Surgery: A Single Center Retrospective Study Open
Background Thromboembolism (TE) is a complication in pediatric patients with congenital heart disease (CHD) due to disrupted blood flow, inflammation, foreign materials and cardiac surgery. Reported rates of TE in pediatric patients with C…
View article: Pharmacist Avoidance or Reductions in Medical Costs in Critically and Emergently Ill Pediatrics: PHARM-PEDS Study
Pharmacist Avoidance or Reductions in Medical Costs in Critically and Emergently Ill Pediatrics: PHARM-PEDS Study Open
OBJECTIVES: To comprehensively classify interventions performed by pediatric critical care clinical pharmacists and quantify cost avoidance (CA) generated through their accepted interventions. DESIGN: A multicenter, prospective, observatio…
View article: OC 48.3 Anticoagulation with Intravenous Direct Thrombin Inhibitors in Pediatric ECMO: A Systematic Review
OC 48.3 Anticoagulation with Intravenous Direct Thrombin Inhibitors in Pediatric ECMO: A Systematic Review Open
S. pneumoniae or S. aureus were instilled intranasally into C57BL/6 or vWF-/-mice.Lungs and blood were taken for further analysis.Results: Infusion of anti-αIIbβ3 mAb induced platelet recruitment to the liver with flow-dependent binding of…
View article: Sotalol in neonates for arrhythmias: Dosing, safety, and efficacy
Sotalol in neonates for arrhythmias: Dosing, safety, and efficacy Open
Introduction Various agents may be utilized to manage supraventricular tachycardia (SVT) in neonates and infants. Recently, sotalol has piqued interest given its reported success in managing neonates and infants with SVTs, especially with …
View article: Retrospective observational study of chloral hydrate use in mechanically-ventilated pediatric intensive care unit (PICU) patients 2012–2017
Retrospective observational study of chloral hydrate use in mechanically-ventilated pediatric intensive care unit (PICU) patients 2012–2017 Open
Introduction: Chloral hydrate (CH) has long been utilized as a pediatric procedural sedation agent. However, very little is published describing CH use in a pediatric intensive care unit (PICU) setting. The aim of this retrospective observ…
View article: Pediatric Extracorporeal Membrane Oxygenation Anticoagulation and Monitoring: Where We Were and Where Are We Now?
Pediatric Extracorporeal Membrane Oxygenation Anticoagulation and Monitoring: Where We Were and Where Are We Now? Open
Extracorporeal membrane oxygenation (ECMO) support in neonates and pediatric patients has continued to advance. In addition to technologic progress, there is a growing interest in the anticoagulation agents and laboratory monitoring strate…