Amy L. Upton
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View article: Chromosomal over-replication in Escherichia coli recG cells is triggered by replication fork fusion and amplified if replichore symmetry is disturbed
Chromosomal over-replication in Escherichia coli recG cells is triggered by replication fork fusion and amplified if replichore symmetry is disturbed Open
Chromosome duplication initiates via the assembly of replication forks at defined origins. Forks proceed in opposite directions until they fuse with a converging fork. Recent work highlights that fork fusions are highly choreographed both …
View article: MatP regulates the coordinated action of topoisomerase IV and MukBEF in chromosome segregation
MatP regulates the coordinated action of topoisomerase IV and MukBEF in chromosome segregation Open
The Escherichia coli SMC complex, MukBEF, forms clusters of molecules that interact with the decatenase topisomerase IV and which are normally associated with the chromosome replication origin region ( ori ). Here we demonstrate an additio…
View article: The Consequences of Replicating in the Wrong Orientation: Bacterial Chromosome Duplication without an Active Replication Origin
The Consequences of Replicating in the Wrong Orientation: Bacterial Chromosome Duplication without an Active Replication Origin Open
Chromosome replication is regulated in all organisms at the assembly stage of the replication machinery at specific origins. In Escherichia coli , the DnaA initiator protein regulates the assembly of replication forks at oriC. This regulat…
View article: Shaping the landscape of the<i>Escherichia coli</i>chromosome: replication-transcription encounters in cells with an ectopic replication origin
Shaping the landscape of the<i>Escherichia coli</i>chromosome: replication-transcription encounters in cells with an ectopic replication origin Open
Each cell division requires the unwinding of millions of DNA base pairs to allow chromosome duplication and gene transcription. As DNA replication and transcription share the same template, conflicts between both processes are unavoidable …