Amy Lehman
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View article: Cell type specific contributions of mTOR inhibition that drive neuroprotective mechanisms in Alzheimer’s disease
Cell type specific contributions of mTOR inhibition that drive neuroprotective mechanisms in Alzheimer’s disease Open
Background Studies investigating mTOR signaling provide compelling and reproducible evidence of the extension of lifespan across model organisms by treatment with the mTOR inhibitor rapamycin, and preclinical data suggests neuroprotective …
View article: Rural-Urban Residence and Stroke Risk and Severity in Postmenopausal Women: The Women's Health Initiative
Rural-Urban Residence and Stroke Risk and Severity in Postmenopausal Women: The Women's Health Initiative Open
Background: The impact of rural-urban residence on stroke risk and poor stroke outcomes among postmenopausal women is unknown. Methods: We used data from the Women's Health Initiative (WHI) (1993-2014; n = 155,186) to test the hypothesis t…
View article: Rural-urban residence and stage at breast cancer diagnosis among postmenopausal women: The women's health initiative
Rural-urban residence and stage at breast cancer diagnosis among postmenopausal women: The women's health initiative Open
Background: Although social exposures have complex and dynamic relationships and interactions, the existing literature on the impact of rural-urban residence on stage at breast cancer diagnosis does not examine heterogeneity of effect. We …
View article: Correction: Associations of coffee/caffeine consumption with postmenopausal breast cancer risk and their interactions with postmenopausal hormone use
Correction: Associations of coffee/caffeine consumption with postmenopausal breast cancer risk and their interactions with postmenopausal hormone use Open
View article: Pre‐diagnosis lipid levels and mortality after obesity‐related cancer diagnosis in the Women's Health Initiative cardiovascular disease biomarker cohort
Pre‐diagnosis lipid levels and mortality after obesity‐related cancer diagnosis in the Women's Health Initiative cardiovascular disease biomarker cohort Open
Background Published studies have demonstrated inconclusive relationships between serum lipid levels and mortality after cancer. Methods The primary objective was to evaluate the relationship between fasting lipid levels and mortality afte…
View article: Supplementary Figure Legend from The Proteasome Inhibitor Carfilzomib Functions Independently of p53 to Induce Cytotoxicity and an Atypical NF-κB Response in Chronic Lymphocytic Leukemia Cells
Supplementary Figure Legend from The Proteasome Inhibitor Carfilzomib Functions Independently of p53 to Induce Cytotoxicity and an Atypical NF-κB Response in Chronic Lymphocytic Leukemia Cells Open
PDF file - 183K
View article: Supplementary Figure 2 from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas
Supplementary Figure 2 from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas Open
PDF file - 7683K, HSV Antigen immunohistochemistry.
View article: Data from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas
Data from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas Open
Purpose: Oncolytic viruses (OV) based on herpes simplex virus type 1 (HSV1) are being used in clinical trials for a variety of cancers. The OV, rQNestin34.5, uses a nestin promoter/enhancer to selectively drive robust viral replicat…
View article: Data from The Proteasome Inhibitor Carfilzomib Functions Independently of p53 to Induce Cytotoxicity and an Atypical NF-κB Response in Chronic Lymphocytic Leukemia Cells
Data from The Proteasome Inhibitor Carfilzomib Functions Independently of p53 to Induce Cytotoxicity and an Atypical NF-κB Response in Chronic Lymphocytic Leukemia Cells Open
Purpose: The proteasome consists of chymotrypsin-like (CT-L), trypsin-like, and caspase-like subunits that cleave substrates preferentially by amino acid sequence. Proteasomes mediate degradation of regulatory proteins of the p53, B…
View article: Supplementary Figure Legend from The Proteasome Inhibitor Carfilzomib Functions Independently of p53 to Induce Cytotoxicity and an Atypical NF-κB Response in Chronic Lymphocytic Leukemia Cells
Supplementary Figure Legend from The Proteasome Inhibitor Carfilzomib Functions Independently of p53 to Induce Cytotoxicity and an Atypical NF-κB Response in Chronic Lymphocytic Leukemia Cells Open
PDF file - 183K
View article: Supplementary Figure Legend from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas
Supplementary Figure Legend from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas Open
PDF file - 96K
View article: Supplementary Table 1, Figure 1 from The Proteasome Inhibitor Carfilzomib Functions Independently of p53 to Induce Cytotoxicity and an Atypical NF-κB Response in Chronic Lymphocytic Leukemia Cells
Supplementary Table 1, Figure 1 from The Proteasome Inhibitor Carfilzomib Functions Independently of p53 to Induce Cytotoxicity and an Atypical NF-κB Response in Chronic Lymphocytic Leukemia Cells Open
PDF file - 82K, Supplementary Table 1: Fold changes of NF-κB target genes in CLL: CLL cells (n=12) were treated with 300 nM CFZ (1 hr), 1.7 �M CpG (4 hr) or 500 ng/ml CD40L (4 hr). RNA was extracted at 8 hr from CFZ treated samples and mRN…
View article: Data from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas
Data from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas Open
Purpose: Oncolytic viruses (OV) based on herpes simplex virus type 1 (HSV1) are being used in clinical trials for a variety of cancers. The OV, rQNestin34.5, uses a nestin promoter/enhancer to selectively drive robust viral replicat…
View article: Supplementary Figure 1 from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas
Supplementary Figure 1 from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas Open
PDF file - 1614K, Methylated CpG sites in the Nestin promoter region of rQNestin34.5, immediately upstream of the gamma1 34.5 gene.
View article: Supplementary Figure Legend from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas
Supplementary Figure Legend from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas Open
PDF file - 96K
View article: Supplementary Figure 1 from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas
Supplementary Figure 1 from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas Open
PDF file - 1614K, Methylated CpG sites in the Nestin promoter region of rQNestin34.5, immediately upstream of the gamma1 34.5 gene.
View article: Supplementary Figure 2 from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas
Supplementary Figure 2 from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas Open
PDF file - 7683K, HSV Antigen immunohistochemistry.
View article: Supplementary Table 1, Figure 1 from The Proteasome Inhibitor Carfilzomib Functions Independently of p53 to Induce Cytotoxicity and an Atypical NF-κB Response in Chronic Lymphocytic Leukemia Cells
Supplementary Table 1, Figure 1 from The Proteasome Inhibitor Carfilzomib Functions Independently of p53 to Induce Cytotoxicity and an Atypical NF-κB Response in Chronic Lymphocytic Leukemia Cells Open
PDF file - 82K, Supplementary Table 1: Fold changes of NF-κB target genes in CLL: CLL cells (n=12) were treated with 300 nM CFZ (1 hr), 1.7 �M CpG (4 hr) or 500 ng/ml CD40L (4 hr). RNA was extracted at 8 hr from CFZ treated samples and mRN…
View article: Data from The Proteasome Inhibitor Carfilzomib Functions Independently of p53 to Induce Cytotoxicity and an Atypical NF-κB Response in Chronic Lymphocytic Leukemia Cells
Data from The Proteasome Inhibitor Carfilzomib Functions Independently of p53 to Induce Cytotoxicity and an Atypical NF-κB Response in Chronic Lymphocytic Leukemia Cells Open
Purpose: The proteasome consists of chymotrypsin-like (CT-L), trypsin-like, and caspase-like subunits that cleave substrates preferentially by amino acid sequence. Proteasomes mediate degradation of regulatory proteins of the p53, B…
View article: Calcium Supplements and Risk of CVD: A Meta-Analysis of Randomized Trials
Calcium Supplements and Risk of CVD: A Meta-Analysis of Randomized Trials Open
View article: Dysregulation of PRMT5 in Chronic Lymphocytic Leukemia Promotes Progression with High Risk of Richter's Transformation
Dysregulation of PRMT5 in Chronic Lymphocytic Leukemia Promotes Progression with High Risk of Richter's Transformation Open
Richter’s Transformation (RT) is a poorly understood and fatal progression of chronic lymphocytic leukemia (CLL) manifesting histologically as diffuse large B-cell lymphoma. PRMT5 is implicated in lymphomagenesis, but its role in CLL or RT…
View article: Targeting OXPHOS de novo purine synthesis as the nexus of <i>FLT3</i> inhibitor–mediated synergistic antileukemic actions
Targeting OXPHOS de novo purine synthesis as the nexus of <i>FLT3</i> inhibitor–mediated synergistic antileukemic actions Open
Using a genome-wide CRISPR screen, we identified CDK9 , DHODH , and PRMT5 as synthetic lethal partners with gilteritinib treatment in fms-like tyrosine kinase 3 ( FLT3 )–internal tandem duplication (ITD) acute myeloid leukemia (AML) and ge…
View article: Associations of coffee/caffeine consumption with postmenopausal breast cancer risk and their interactions with postmenopausal hormone use
Associations of coffee/caffeine consumption with postmenopausal breast cancer risk and their interactions with postmenopausal hormone use Open
View article: Lightweight Mobile Automated Assistant-to-physician for Global Lower-resource Areas
Lightweight Mobile Automated Assistant-to-physician for Global Lower-resource Areas Open
Importance Lower-resource areas in Africa and Asia face a unique set of healthcare challenges: the dual high burden of communicable and non-communicable diseases; a paucity of highly trained primary healthcare providers in both rural and d…
View article: Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia
Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia Open
View article: Lightweight Mobile Automated Assistant-to-physician for Global Lower-resource Areas
Lightweight Mobile Automated Assistant-to-physician for Global Lower-resource Areas Open
Importance: Lower-resource areas in Africa and Asia face a unique set of healthcare challenges: the dual high burden of communicable and non-communicable diseases; a paucity of highly trained primary healthcare providers in both rural and …
View article: Ibrutinib treatment ameliorates murine chronic graft-versus-host disease
Ibrutinib treatment ameliorates murine chronic graft-versus-host disease Open
Chronic graft-versus-host disease (cGVHD) is a life-threatening impediment to allogeneic hematopoietic stem cell transplantation, and current therapies do not completely prevent and/or treat cGVHD. CD4+ T cells and B cells mediate cGVHD; t…
View article: Anti-tumor NAMPT inhibitor, KPT-9274, mediates gender-dependent murine anemia and nephrotoxicity by regulating SIRT3-mediated SOD deacetylation
Anti-tumor NAMPT inhibitor, KPT-9274, mediates gender-dependent murine anemia and nephrotoxicity by regulating SIRT3-mediated SOD deacetylation Open
View article: Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia
Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia Open
View article: Synergistic effect of BCL2 and FLT3 co-inhibition in acute myeloid leukemia
Synergistic effect of BCL2 and FLT3 co-inhibition in acute myeloid leukemia Open
Acute myeloid leukemia (AML) is a heterogeneous and complex disease, and treatments for this disease have not been curative for the majority of patients. In younger patients, internal tandem duplication of FLT3 ( FLT3 -ITD) is a common mut…