Amy Lock
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View article: Single-cell RNA sequencing clarifies dermal fibroblast subset representation <i>in vitro</i> and reveals variable persistence of keloid disease-associated features
Single-cell RNA sequencing clarifies dermal fibroblast subset representation <i>in vitro</i> and reveals variable persistence of keloid disease-associated features Open
In vitro models of scarring and fibrosis are essential to improve our understanding of disease mechanisms and ultimately develop much-needed effective therapeutic strategies. This is particularly true for keloids, the example of pathologic…
View article: Rheumatoid arthritis synovial fluid induces JAK-dependent intracellular activation of human sensory neurons
Rheumatoid arthritis synovial fluid induces JAK-dependent intracellular activation of human sensory neurons Open
JAK inhibitors (JAKi) are widely used antiinflammatory drugs. Recent data suggest that JAKi have superior effects on pain reduction in rheumatoid arthritis (RA). However, the underlying mechanisms for this observation are not fully underst…
View article: Modelling inflammation-induced peripheral sensitization in a dish—more complex than expected?
Modelling inflammation-induced peripheral sensitization in a dish—more complex than expected? Open
Peripheral sensitization of nociceptors is believed to be a key driver of chronic pain states. Here, we sought to study the effects of a modified version of inflammatory soup on the excitability of human stem cell–derived sensory neurons. …
View article: Blockade of rheumatoid arthritis synovial fluid-induced sensory neuron activation by JAK inhibitors
Blockade of rheumatoid arthritis synovial fluid-induced sensory neuron activation by JAK inhibitors Open
Objective Clinical studies suggest that compared to anti-TNF treatment, JAK inhibitors (JAKi) are superior in reducing pain in rheumatoid arthritis (RA). The underlying mechanisms for this observation are still unknown. Sensory neurons tra…