Amy M. Ehrlich
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View article: HIF1α mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise.
HIF1α mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise. Open
The regulation of metabolism in peripheral tissues is intricately linked to circadian rhythms, with hypoxia-inducible factor-1α (HIF1α) implicated in modulating time-of-day-specific exercise responses. To investigate this relationship, we …
View article: Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake
Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake Open
View article: NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging Open
Nicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numerous regulatory proteins. Dysregulations of NAD metabolism are widely regarded as detriment…
View article: Housing Temperature Impacts the Systemic and Tissue‐Specific Molecular Responses to Cancer in Mice
Housing Temperature Impacts the Systemic and Tissue‐Specific Molecular Responses to Cancer in Mice Open
Background Cancer cachexia, affecting up to 80% of patients with cancer, is characterized by muscle and fat loss with functional decline. Preclinical research seeks to uncover the molecular mechanisms underlying cachexia to identify potent…
View article: Enhanced metabolic adaptations following late dark phase wheel running in high-fat diet-fed mice
Enhanced metabolic adaptations following late dark phase wheel running in high-fat diet-fed mice Open
View article: Housing temperature dictates the systemic and tissue-specific molecular responses to cancer in mice
Housing temperature dictates the systemic and tissue-specific molecular responses to cancer in mice Open
Summary Cancer cachexia is a metabolic condition affecting up to 80% of patients with cancer. Cachexia is mediated by reduced muscle and fat mass and impaired function, and it lowers survival for patients. With no approved drugs to treat c…
View article: Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia Open
View article: Metabolic plasticity and obesity-associated changes in diurnal postexercise metabolism in mice
Metabolic plasticity and obesity-associated changes in diurnal postexercise metabolism in mice Open
Overall, high-fat fed obese mice exhibit metabolic inflexibility, which is also evident in the diurnal exercise response. Our study provides physiological insight into exercise timing-dependent aspects in the dynamic regulation of metaboli…
View article: Insulin and Exercise-induced Phosphoproteomics of Human Skeletal Muscle Identify REPS1 as a New Regulator of Muscle Glucose Uptake
Insulin and Exercise-induced Phosphoproteomics of Human Skeletal Muscle Identify REPS1 as a New Regulator of Muscle Glucose Uptake Open
Skeletal muscle regulates glucose uptake in response to insulin and exercise which is critical for maintaining metabolic health. We conducted a comprehensive phosphoproteomic analysis of skeletal muscle from healthy people in response to a…
View article: Seasonal light hours modulate peripheral clocks and energy metabolism in mice
Seasonal light hours modulate peripheral clocks and energy metabolism in mice Open
Except for latitudes close to the equator, seasonal variation in light hours can change dramatically between summer and winter. Yet investigations into the interplay between energy metabolism and circadian rhythms typically use a 12 h ligh…
View article: Milk oligosaccharide-driven persistence of Bifidobacterium pseudocatenulatum modulates local and systemic microbial metabolites upon synbiotic treatment in conventionally colonized mice
Milk oligosaccharide-driven persistence of Bifidobacterium pseudocatenulatum modulates local and systemic microbial metabolites upon synbiotic treatment in conventionally colonized mice Open
Background Bifidobacteria represent an important gut commensal in humans, particularly during initial microbiome assembly in the first year of life. Enrichment of Bifidobacterium is mediated though the utilization of human milk oligosaccha…
View article: Time of day determines postexercise metabolism in mouse adipose tissue
Time of day determines postexercise metabolism in mouse adipose tissue Open
The circadian clock is a cell-autonomous transcription–translation feedback mechanism that anticipates and adapts physiology and behavior to different phases of the day. A variety of factors including hormones, temperature, food-intake, an…
View article: Protocol to assess arteriovenous differences across the liver and hindlimb muscles in mice following treadmill exercise
Protocol to assess arteriovenous differences across the liver and hindlimb muscles in mice following treadmill exercise Open
The tissue-specific release and uptake of metabolites in response to exercise is incompletely understood. Here, we detail a protocol to assess arteriovenous differences across the liver and hindlimb muscles in response to treadmill exercis…
View article: The 5-Cog Paradigm to Improve Detection of Cognitive Impairment and Dementia: Clinical Trial Protocol
The 5-Cog Paradigm to Improve Detection of Cognitive Impairment and Dementia: Clinical Trial Protocol Open
Cognitive impairment related to dementia is under-diagnosed in primary care despite availability of numerous cognitive assessment tools; under-diagnosis is more prevalent for members of racial and ethnic minority groups. Clinical decision-…
View article: Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis Open
View article: Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice
Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice Open
View article: Bifidobacteria-mediated immune system imprinting early in life
Bifidobacteria-mediated immune system imprinting early in life Open
Immune-microbe interactions early in life influence the risk of allergies, asthma, and other inflammatory diseases. Breastfeeding guides healthier immune-microbe relationships by providing nutrients to specialized microbes that in turn ben…
View article: Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity
Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity Open
View article: Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle
Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle Open
View article: <i>Bifidobacterium</i> catabolism of human milk oligosaccharides overrides endogenous competitive exclusion driving colonization and protection
<i>Bifidobacterium</i> catabolism of human milk oligosaccharides overrides endogenous competitive exclusion driving colonization and protection Open
Understanding how exogenous microbes stably colonize the animal gut is essential to reveal mechanisms of action and tailor effective probiotic treatments. Bifidobacterium species are naturally enriched in the gastrointestinal tract …
View article: Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells
Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells Open
Background Bifidobacterium longum subsp. infantis ( B. infantis ) is a commensal bacterium that colonizes the gastrointestinal tract of breast-fed infants. B. infantis can efficiently utilize the abundant supply of oligosaccharides found i…
View article: 171 Young Scholar Presentation: Dietary supplementation of Bacillus subtilis influenced intestinal health and metabolomic profiles of weaned pigs experimentally infected with a pathogenic E. coli
171 Young Scholar Presentation: Dietary supplementation of Bacillus subtilis influenced intestinal health and metabolomic profiles of weaned pigs experimentally infected with a pathogenic E. coli Open
There is growing evidence to support the beneficial effects of supplementing direct-fed microbials (DFM) on performance, health status, and immune responses of weaned pigs. Therefore, the objective of this study was to investigate dietary …
View article: Bifidobacteria-mediated immune system imprinting early in life
Bifidobacteria-mediated immune system imprinting early in life Open
SUMMARY Immune-microbe interactions early in life influence an individual’s risk of developing allergies, asthma and some autoimmune disorders. Breastfeeding helps guide the development of healthy immune-microbe relationships, in part by p…
View article: Contraction influences <i>Per2</i> gene expression in skeletal muscle through a calcium‐dependent pathway
Contraction influences <i>Per2</i> gene expression in skeletal muscle through a calcium‐dependent pathway Open
Key points Exercising at different times of day elicits different effects on exercise performance and metabolic health. However, the specific signals driving the observed time‐of‐day specific effects of exercise have not been fully identif…
View article: B. Infantis EVC001 Metabolites Improve Enterocyte Proliferation in Vitro
B. Infantis EVC001 Metabolites Improve Enterocyte Proliferation in Vitro Open
OBJECTIVES: Bacterial metabolites, including short chain fatty acids (SCFA) are essential for host cells to maintain homeostasis. Previous findings showed exclusively breastfed infants colonized with B. infantis EVC001 have significantly i…
View article: Dietary supplementation of Bacillus subtilis influenced intestinal health of weaned pigs experimentally infected with a pathogenic E. coli
Dietary supplementation of Bacillus subtilis influenced intestinal health of weaned pigs experimentally infected with a pathogenic E. coli Open
Background There is growing evidence to support the beneficial effects of supplementing direct-fed microbials (DFM) on performance, health status, and immune responses of weaned pigs. Therefore, the objective of this study was to investiga…
View article: UC Davis - Ex vivo assessment of barrier function-gut permeability v1
UC Davis - Ex vivo assessment of barrier function-gut permeability v1 Open
Summary: Gut tissue (by region- e.g ileum & colon) will be opened along the mesenteric border and mounted in Ussing chambers (Physiologic Instruments, San Diego, CA, USA), exposing 0.3 cm² of tissue surface area to 2.5ml of oxygenated Kreb…
View article: 069 Effects of dietary β-glucan on growth performance, diarrhea, and gut permeability of weanling pigs experimentally infected with a pathogenic Escherichia coli
069 Effects of dietary β-glucan on growth performance, diarrhea, and gut permeability of weanling pigs experimentally infected with a pathogenic Escherichia coli Open
ProGlucan is 100% dried algae, Euglena gracillus, which contains approximately 54% β-1,3-glucan. The objective of this experiment was to investigate the influence of dietary supplementation of ProGlucan on growth performance, diarrhea scor…
View article: POST-ACUTE CARE IN CJR-THE CRITICAL ROLE OF THE CERTIFIED HOME HEALTH AGENCY (CHHA)
POST-ACUTE CARE IN CJR-THE CRITICAL ROLE OF THE CERTIFIED HOME HEALTH AGENCY (CHHA) Open
Talk #4 Content Outline The speakers will outline the stages from design to implementation of a joint replacement program in a CHHA including collaboration with orthopedics, hospital leadership and discharge team; development of clinical p…
View article: Bundle in the Bronx: Impact of a Transition-of-Care Outpatient Parenteral Antibiotic Therapy Bundle on All-Cause 30-Day Hospital Readmissions
Bundle in the Bronx: Impact of a Transition-of-Care Outpatient Parenteral Antibiotic Therapy Bundle on All-Cause 30-Day Hospital Readmissions Open
Background A streamlined transition from inpatient to outpatient care can decrease 30-day readmissions. Outpatient parenteral antibiotic therapy (OPAT) programs have not reduced readmissions; an OPAT bundle has been suggested to improve ou…