Amy Miles
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View article: Brain structure and working memory adaptations associated with maturation and aging in mice
Brain structure and working memory adaptations associated with maturation and aging in mice Open
Introduction As the population skews toward older age, elucidating mechanisms underlying human brain aging becomes imperative. Structural MRI has facilitated non-invasive investigation of lifespan brain morphology changes, yet this domain …
View article: Brain Structure and Working Memory Adaptations Associated with Maturation and Aging in Mice
Brain Structure and Working Memory Adaptations Associated with Maturation and Aging in Mice Open
Introduction As the population skews toward older age, elucidating mechanisms underlying human brain aging becomes imperative. Structural MRI has facilitated non-invasive investigation of lifespan brain morphology changes, yet this domain …
View article: Neuroimaging features of depression–frailty phenotype in older adults: a pilot study
Neuroimaging features of depression–frailty phenotype in older adults: a pilot study Open
We showed the LLD+Frailty group is associated with significant microstructural changes within WM tracts compared to Never-depressed+Robust individuals. Our findings indicate the possibility of a heightened neuroinflammatory burden as a pot…
View article: Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group
Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group Open
View article: Energetic constraints drive sex‐specific parental care in the monomorphic Leach's storm‐petrel <i>Hydrobates leucorhous</i>
Energetic constraints drive sex‐specific parental care in the monomorphic Leach's storm‐petrel <i>Hydrobates leucorhous</i> Open
Sex‐specific parental care in dimorphic species may be unsurprising, but why this occurs in monomorphic species is more puzzling. To date, however, there have been few examinations of the causes of this phenomenon. Here, we evaluated possi…
View article: Prenatal stress and its association with amygdala-related structural covariance patterns in youth
Prenatal stress and its association with amygdala-related structural covariance patterns in youth Open
View article: Author response for "Energetic constraints drive sex‐specific parental care in the monomorphic Leach's storm‐petrel Hydrobates leucorhous"
Author response for "Energetic constraints drive sex‐specific parental care in the monomorphic Leach's storm‐petrel Hydrobates leucorhous" Open
View article: Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk
Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk Open
View article: Correction: Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms
Correction: Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms Open
A Correction to this paper has been published: https://doi.org/10.1038/s41398-021-01277-y
View article: Novel polygenic risk score links depression-related cortical transcriptomic changes to brain morphology and symptom severity
Novel polygenic risk score links depression-related cortical transcriptomic changes to brain morphology and symptom severity Open
Our group developed a transcriptome-based polygenic risk score (T-PRS) that uses common genetic variants to capture ‘depression-like’ shifts in cortical gene expression. Here, we mapped T-PRS onto diagnosis and symptom severity in major de…
View article: Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms
Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms Open
View article: Assessing Exposure to Disinfection By-products in Women of Reproductive Age Living in Corpus Christi, Texas, and Cobb County, Georgia: Descriptive Results and Methods
Assessing Exposure to Disinfection By-products in Women of Reproductive Age Living in Corpus Christi, Texas, and Cobb County, Georgia: Descriptive Results and Methods Open
We conducted a field study in Corpus Christi, Texas, and Cobb County, Georgia, to evaluate exposure measures for disinfection by-products, with special emphasis on trihalomethanes (THMs). Participants were mothers living in either geograph…
View article: Temporally and sex‐specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood
Temporally and sex‐specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood Open
Maternal stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the fi…
View article: Reduced anterior cingulate cortex volume induced by chronic stress correlates with increased behavioral emotionality and decreased synaptic puncta density
Reduced anterior cingulate cortex volume induced by chronic stress correlates with increased behavioral emotionality and decreased synaptic puncta density Open
Clinical and preclinical studies report that chronic stress induces behavioral deficits as well as volumetric and synaptic alterations in corticolimbic brain regions including the anterior cingulate cortex (ACC), amygdala (AMY), nucleus ac…
View article: Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms
Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms Open
Convergent data from imaging and postmortem brain transcriptome studies implicate corticolimbic circuit (CLC) dysregulation in the pathophysiology of depression. To more directly bridge these lines of work, we generated a novel transcripto…
View article: White matter microstructure in women with acute and remitted anorexia nervosa: an exploratory neuroimaging study
White matter microstructure in women with acute and remitted anorexia nervosa: an exploratory neuroimaging study Open
Anorexia nervosa (AN) is a highly heritable psychiatric disorder characterized by starvation and emaciation and associated with changes in brain structure. The precise nature of these changes remains unclear, as does their developmental ti…
View article: Structural neuroimaging signatures of anorexia nervosa features in a mixed sample enriched for disease vulnerability
Structural neuroimaging signatures of anorexia nervosa features in a mixed sample enriched for disease vulnerability Open
Brain-behavior relationships that could provide insight into risk-associated pathophysiology have not been thoroughly assessed in anorexia nervosa (AN). Therefore, we sought to identify grey and white matter signatures of AN symptoms and r…