Amy Mohan
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View article: Reduced Notch1 Cleavage Promotes the Development of Pulmonary Hypertension
Reduced Notch1 Cleavage Promotes the Development of Pulmonary Hypertension Open
Clinical trials of Dll4 (Delta-like 4) neutralizing antibodies (Dll4nAbs) in cancer patients are ongoing. Surprisingly, pulmonary hypertension (PH) occurs in 14% to 18% of patients treated with Dll4nAbs, but the mechanisms have not been st…
View article: Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm
Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm Open
Significance The rupture of abdominal aortic aneurysm (AAA) has high mortality while lacking effective therapeutics to prevent aneurysm progression. Identifying the regulators underlying aneurysm pathogenesis is essential. Herein, we repor…
View article: Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin
Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin Open
Rationale: Cardiomyopathy is characterized by the deposition of extracellular matrix by activated resident cardiac fibroblasts called myofibroblasts. There are currently no therapeutic approaches to blunt the development of pathological fi…
View article: Sex-Specific Platelet Activation Through Protease-Activated Receptors Reverses in Myocardial Infarction
Sex-Specific Platelet Activation Through Protease-Activated Receptors Reverses in Myocardial Infarction Open
Objective: The platelet phenotype in certain patients and clinical contexts may differ from healthy conditions. We evaluated platelet activation through specific receptors in healthy men and women, comparing this to patients presenting wit…
View article: Vinpocetine protects against the development of experimental abdominal aortic aneurysms
Vinpocetine protects against the development of experimental abdominal aortic aneurysms Open
Abdominal aortic aneurysm (AAA), commonly occurring in the aged population, is a degenerative disease that dilate and weaken infrarenal aorta due to progressive degeneration of aortic wall integrity. Vinpocetine, a derivative of alkaloid v…
View article: Platelet-derived β2m regulates age related monocyte/macrophage functions
Platelet-derived β2m regulates age related monocyte/macrophage functions Open
Platelets have central roles in both immune responses and development. Stimulated platelets express leukocyte adhesion molecules and release numerous immune modulatory factors that recruit and activate leukocytes, both at the sites of acti…
View article: Platelet-derived β2M regulates monocyte inflammatory responses
Platelet-derived β2M regulates monocyte inflammatory responses Open
β-2 Microglobulin (β2M) is a molecular chaperone for the major histocompatibility class I (MHC I) complex, hemochromatosis factor protein (HFE), and the neonatal Fc receptor (FcRn), but β2M may also have less understood chaperone-independe…
View article: Multiprotein Complex With TRPC (Transient Receptor Potential-Canonical) Channel, PDE1C (Phosphodiesterase 1C), and A2R (Adenosine A2 Receptor) Plays a Critical Role in Regulating Cardiomyocyte cAMP and Survival
Multiprotein Complex With TRPC (Transient Receptor Potential-Canonical) Channel, PDE1C (Phosphodiesterase 1C), and A2R (Adenosine A2 Receptor) Plays a Critical Role in Regulating Cardiomyocyte cAMP and Survival Open
Background: cAMP plays a critical role in regulating cardiomyocyte survival. Various cAMP signaling pathways behave distinctly or in opposition. We have previously reported that activation of cAMP hydrolysis by cyclic nucleotide phosphodie…
View article: Hypoxia and Ischemia Promote a Maladaptive Platelet Phenotype
Hypoxia and Ischemia Promote a Maladaptive Platelet Phenotype Open
Objective— Reduced blood flow and tissue oxygen tension conditions result from thrombotic and vascular diseases such as myocardial infarction, stroke, and peripheral vascular disease. It is largely assumed that while platelet activation is…