Amy N. Riesenberg
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View article: Modelling a pathological <i>GSX2</i> variant that selectively alters DNA binding reveals hypomorphic mouse brain defects
Modelling a pathological <i>GSX2</i> variant that selectively alters DNA binding reveals hypomorphic mouse brain defects Open
Gsx2 is a homeodomain transcription factor critical for development of the ventral telencephalon and hindbrain in mouse. Loss of Gsx2 function results in severe basal ganglia dysgenesis and defects in the nucleus tractus solitarius (nTS) o…
View article: Prenatal psychosocial stress-induced behavioral and neuroendocrine abnormalities are associated with sex-specific alterations in synaptic transmission and differentially modulated by maternal environment
Prenatal psychosocial stress-induced behavioral and neuroendocrine abnormalities are associated with sex-specific alterations in synaptic transmission and differentially modulated by maternal environment Open
Prenatal stress (PS) is associated with increased vulnerability to affective disorders. Transplacental glucocorticoid passage and stress-induced maternal environment alterations are recognized as potential routes of transmission that can f…
View article: Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina
Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina Open
In vertebrate retinal progenitor cells, the proneural factor Atoh7 exhibits a dynamic tissue and cellular expression pattern. Although the resulting Atoh7 retinal lineage contains all seven major cell types, only retinal ganglion cells req…
View article: Separate and coincident expression of <i>Hes1</i> and <i>Hes5</i> in the developing mouse eye
Separate and coincident expression of <i>Hes1</i> and <i>Hes5</i> in the developing mouse eye Open
Background : Notch signaling is broadly required during embryogenesis, frequently activating the transcription of two basic helix–loop–helix transcription factors, Hes1 and Hes5 . But, it remains unresolved when and where Hes1 and Hes5 act…
View article: Cell autonomous and nonautonomous requirements for Delltalike1 during early mouse retinal neurogenesis
Cell autonomous and nonautonomous requirements for Delltalike1 during early mouse retinal neurogenesis Open
Background: In the vertebrate retina, six neuronal and one glial cell class are produced from a common progenitor pool. During neurogenesis, adjacent retinal cells use Notch signaling to maintain a pool of progenitors by blocking particula…