Amy P. Patterson
YOU?
Author Swipe
View article: APOBEC-1 cofactors regulate APOBEC3-induced mutations in hepatitis B virus
APOBEC-1 cofactors regulate APOBEC3-induced mutations in hepatitis B virus Open
APOBEC3 proteins (A3s) play an important role in host innate immunity against viruses and DNA mutations in cancer. A3s-induced mutations in both viral and human DNA genomes vary significantly from non-lethal mutations in viruses to localiz…
View article: Class B Scavenger Receptor CD36 as a Potential Therapeutic Target in Inflammation Induced by Danger-Associated Molecular Patterns
Class B Scavenger Receptor CD36 as a Potential Therapeutic Target in Inflammation Induced by Danger-Associated Molecular Patterns Open
The class B scavenger receptor CD36 is known to bind and mediate the transport of lipid-related ligands and it functions as a pattern recognition receptor (PRR) for a variety of pathogens, including bacteria and viruses. In this study, we …
View article: Lessons Learned from National Heart, Lung, and Blood Institute Covid-19 Clinical Trials
Lessons Learned from National Heart, Lung, and Blood Institute Covid-19 Clinical Trials Open
In response to the Covid-19 pandemic, the National Heart, Lung, and Blood Institute launched five multisite clinical trials testing candidate host tissue-directed medical interventions to hasten recovery, improve function, and reduce morbi…
View article: Gene Therapy: Charting a Future Course—Summary of a National Institutes of Health Workshop, April 12, 2013
Gene Therapy: Charting a Future Course—Summary of a National Institutes of Health Workshop, April 12, 2013 Open
Recently, the gene therapy field has begun to experience clinical successes in a number of different diseases using various approaches and vectors. The workshop Gene Therapy: Charting a Future Course, sponsored by the National Institutes o…
View article: SR-BI mediates neutral lipid sorting from LDL to lipid droplets and facilitates their formation
SR-BI mediates neutral lipid sorting from LDL to lipid droplets and facilitates their formation Open
SR-BI binds various lipoproteins, including HDL, LDL as well as VLDL, and mediates selective cholesteryl ester (CE) uptake. HDL derived CE accumulates in cellular lipid droplets (LDs), which also store triacylglycerol (TAG). We hypothesize…
View article: At the Crossroads of Science and Society: Careers in Science Policy
At the Crossroads of Science and Society: Careers in Science Policy Open
Science policy offers a challenging and rewarding career path for scientists interested in the social, ethical, and legal implications of their field. This topic encompasses a broad spectrum of activities all in support of advancing the sc…
View article: Colon Epithelial MicroRNA Network in Fatty Liver
Colon Epithelial MicroRNA Network in Fatty Liver Open
Background & Aims. Intestinal barrier alterations are associated with fatty liver (FL) and metabolic syndrome (MetS), but microRNA (miR) signaling pathways in MetS-FL pathogenesis remain unclear. This study investigates an epithelial-focus…
View article: Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo
Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo Open
Serum amyloid A (SAA) is an acute phase protein with cytokine-like and chemotactic properties, that is markedly up-regulated during various inflammatory conditions. Several receptors, including FPRL-1, TLR2, TLR4, RAGE, class B scavenger r…
View article: Human SR-BI and SR-BII Potentiate Lipopolysaccharide-Induced Inflammation and Acute Liver and Kidney Injury in Mice
Human SR-BI and SR-BII Potentiate Lipopolysaccharide-Induced Inflammation and Acute Liver and Kidney Injury in Mice Open
The class B scavenger receptors BI (SR-BI) and BII (SR-BII) are high-density lipoprotein receptors that recognize various pathogens, including bacteria and their products. It has been reported that SR-BI/II null mice are more sensitive tha…