Amy Pascoe
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View article: Airflow for reducing breathlessness in people with serious respiratory illness: a systematic review
Airflow for reducing breathlessness in people with serious respiratory illness: a systematic review Open
Background Increased airflow is reported as helpful in reducing the sensation of breathlessness. This systematic review aimed to assess the effectiveness of airflow on breathlessness (primary outcome, measured using a validated tool at res…
View article: Diversity and inclusivity in clinical trial populations for maintenance inhaler therapy in people with COPD: a systematic review
Diversity and inclusivity in clinical trial populations for maintenance inhaler therapy in people with COPD: a systematic review Open
Introduction Social determinants of health (SDH) influence chronic obstructive pulmonary disease (COPD) prevalence, progression, and treatment, yet their inclusion in clinical trials is poorly understood. This study examined recruitment st…
View article: Social determinants of health in clinical trials examining long-term oral antibiotics in COPD: a systematic review
Social determinants of health in clinical trials examining long-term oral antibiotics in COPD: a systematic review Open
Introduction Social determinants of health (SDH) including age, sex, ethnicity, socioeconomic status, education, occupation and rural status impact the development and prognosis of COPD. Nevertheless, it is unclear whether SDH are reported…
View article: Managing breathlessness for people with advanced respiratory disease
Managing breathlessness for people with advanced respiratory disease Open
Chronic respiratory diseases encompass diverse, nonmalignant respiratory diseases that share common symptoms, including cough, fatigue and chronic breathlessness. Chronic breathlessness imposes a significant burden on patients and is chall…
View article: Lack of diversity in antifibrotic trials for pulmonary fibrosis: a systematic review
Lack of diversity in antifibrotic trials for pulmonary fibrosis: a systematic review Open
Introduction Social determinants of health (SDH), including age, sex, ethnicity, socioeconomic status and rurality, influence health outcomes. Clinical trials investigating antifibrotic agents for people with idiopathic pulmonary fibrosis …
View article: A mixed-methods pilot study of domiciliary nasal high-flow therapy for breathlessness in people with chronic obstructive pulmonary disease who do not qualify for domiciliary long-term oxygen therapy
A mixed-methods pilot study of domiciliary nasal high-flow therapy for breathlessness in people with chronic obstructive pulmonary disease who do not qualify for domiciliary long-term oxygen therapy Open
Background: High-flow nasal oxygen (HFNO) therapy delivers humidified, heated air with flow rates of up to 60 L/min with oxygen entrained. HFNO has advantages over conventional oxygen therapy, including precise and reliable fraction of ins…
View article: A narrative review of proactive palliative care models for people with COPD
A narrative review of proactive palliative care models for people with COPD Open
Chronic obstructive pulmonary disease (COPD) refers to a group of lung diseases that are distinct in underlying aetiology but share a common disease course of persistent and progressive airflow restriction. People living with COPD, as well…
View article: Opioids for the palliation of symptoms in people with serious respiratory illness: a systematic review and meta-analysis
Opioids for the palliation of symptoms in people with serious respiratory illness: a systematic review and meta-analysis Open
Background People living with serious respiratory illness experience a high burden of distressing symptoms. Although opioids are prescribed for symptom management, they generate adverse events, and their benefits are unclear. Methods We ex…
View article: High-flow nasal oxygen therapy compared with conventional oxygen therapy in hospitalised patients with respiratory illness: a systematic review and meta-analysis
High-flow nasal oxygen therapy compared with conventional oxygen therapy in hospitalised patients with respiratory illness: a systematic review and meta-analysis Open
Background High-flow nasal oxygen therapy (HFNO) is used in diverse hospital settings to treat patients with acute respiratory failure (ARF). This systematic review aims to summarise the evidence regarding any benefits HFNO therapy has com…
View article: Provision of palliative care for people with chronic obstructive pulmonary disease: a narrative review
Provision of palliative care for people with chronic obstructive pulmonary disease: a narrative review Open
Despite high level of symptom burden, many people with COPD miss out on palliative care. Expanding capacity of traditional specialist palliative care by upskilling generalist healthcare providers and integrating specialist palliative care …
View article: European Respiratory Society clinical practice guideline on symptom management for adults with serious respiratory illness
European Respiratory Society clinical practice guideline on symptom management for adults with serious respiratory illness Open
Respiratory symptoms are ubiquitous and impair health-related quality of life in people with respiratory disease. This European Respiratory Society (ERS) task force aimed to provide recommendations for symptomatic treatment in people with …
View article: Palliative Approach Remains Lacking in Terminal Hospital Admissions for Chronic Disease Across Rural Settings: Multisite Retrospective Medical Record Audit
Palliative Approach Remains Lacking in Terminal Hospital Admissions for Chronic Disease Across Rural Settings: Multisite Retrospective Medical Record Audit Open
End-of-life planning and specialist palliative care involvement occurred infrequently for people with chronic disease who died in rural hospitals. Targeted strategies are necessary to improve care for these prevalent and high needs rural p…
View article: Breaking the spiral: How negative mood can fuel exertional breathlessness in people with chronic obstructive pulmonary disease
Breaking the spiral: How negative mood can fuel exertional breathlessness in people with chronic obstructive pulmonary disease Open
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View article: Rural general practitioner confidence in diagnosing and managing dementia: A two‐stage, mixed methods study of dementia‐specific training
Rural general practitioner confidence in diagnosing and managing dementia: A two‐stage, mixed methods study of dementia‐specific training Open
Introduction Dementias a prevalent chronic healthcare condition affecting 46 million people worldwide and projected to grow in the coming years. Australians living in rural and regional areas often lack access to specialist dementia care, …
View article: Missing out on effective care in idiopathic pulmonary fibrosis: Racial inequality in access to anti‐fibrotic therapy
Missing out on effective care in idiopathic pulmonary fibrosis: Racial inequality in access to anti‐fibrotic therapy Open
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View article: Social determinants of advanced chronic respiratory interventions: a scoping review
Social determinants of advanced chronic respiratory interventions: a scoping review Open
Introduction Income, education, occupation, social class, sex and race/ethnicity are essential social determinants of health (SDH). Reporting of SDH when testing complex interventions for people with advanced chronic respiratory diseases o…
View article: Mental health symptoms in Australian general practitioners during the COVID-19 pandemic
Mental health symptoms in Australian general practitioners during the COVID-19 pandemic Open
Background General practitioners (GPs) play a central role during the COVID-19 pandemic, and yet awareness of their mental health is limited. Methods A nationwide online survey of self-identified frontline healthcare workers was conducted …
View article: Differences in psychosocial distress among rural and metropolitan health care workers during the <scp>COVID</scp>‐19 pandemic
Differences in psychosocial distress among rural and metropolitan health care workers during the <span>COVID</span>‐19 pandemic Open
Objective The Australian COVID‐19 Frontline Healthcare Workers study examined the prevalence and severity of mental health symptoms during the second wave of the COVID‐19 pandemic. This substudy examined the differences in psychological we…
View article: Thoughts of suicide or self-harm among Australian healthcare workers during the COVID-19 pandemic
Thoughts of suicide or self-harm among Australian healthcare workers during the COVID-19 pandemic Open
Objective: To identify the prevalence and predictors of (a) thoughts of suicide or self-harm among healthcare workers during the COVID-19 pandemic and (b) help-seeking among those healthcare workers with thoughts of suicide or self-harm. M…
View article: Mental Health Symptoms and Workplace Challenges among Australian Paramedics during the COVID-19 Pandemic
Mental Health Symptoms and Workplace Challenges among Australian Paramedics during the COVID-19 Pandemic Open
Background: Paramedics are vital to the health system response to the COVID-19 pandemic; however, the pressures on this workforce have been intense and challenging. This study reports on mental health symptoms and the working environment a…
View article: Differences in Coping Strategies and Help-Seeking Behaviours among Australian Junior and Senior Doctors during the COVID-19 Pandemic
Differences in Coping Strategies and Help-Seeking Behaviours among Australian Junior and Senior Doctors during the COVID-19 Pandemic Open
Background: Throughout the COVID-19 pandemic, hospital medical staff (HMS) have faced significant personal, workplace, and financial disruption. Many have experienced psychosocial burden, exceeding already concerning baseline levels. This …
View article: Differences in Coping Strategies and Help-Seeking Behaviours among Australian Junior and Senior Doctors during the COVID-19 Pandemic
Differences in Coping Strategies and Help-Seeking Behaviours among Australian Junior and Senior Doctors during the COVID-19 Pandemic Open
Background: Throughout the COVID-19 pandemic, hospital medical staff (HMS) have faced significant personal, workplace, and financial disruption. Many have experienced psychosocial burden, exceeding already concerning baseline levels. This …
View article: Occupational Disruptions during the COVID-19 Pandemic and Their Association with Healthcare Workers’ Mental Health
Occupational Disruptions during the COVID-19 Pandemic and Their Association with Healthcare Workers’ Mental Health Open
Background: The COVID-19 crisis has caused prolonged and extreme demands on healthcare services. This study investigates the types and prevalence of occupational disruptions, and associated symptoms of mental illness, among Australian fron…
View article: Moral Distress and Perceived Community Views Are Associated with Mental Health Symptoms in Frontline Health Workers during the COVID-19 Pandemic
Moral Distress and Perceived Community Views Are Associated with Mental Health Symptoms in Frontline Health Workers during the COVID-19 Pandemic Open
Background: Sudden changes in clinical practice and the altered ability to care for patients due to the COVID-19 pandemic have been associated with moral distress and mental health concerns in healthcare workers internationally. This study…
View article: Moral Distress and Perceived Community Views Are Associated With Mental Health Symptoms in Frontline Health Workers During the COVID-19 Pandemic
Moral Distress and Perceived Community Views Are Associated With Mental Health Symptoms in Frontline Health Workers During the COVID-19 Pandemic Open
Background: Sudden changes in clinical practice and the altered ability to care for patients due to the COVID-19 pandemic have been associated with moral distress and mental health concerns in healthcare workers internationally. This study…
View article: TWEAK-Fn14 Signalling in Acute and Chronic Skeletal Muscle Remodelling
TWEAK-Fn14 Signalling in Acute and Chronic Skeletal Muscle Remodelling Open
Submitted in fulfilment of the requirements for Doctor of Philosophy to the Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Victoria, Australia.