Amy Powers
YOU?
Author Swipe
View article: Environmental respiratory hazards epigenetically reprogram macrophages to support tumor progression in lung cancer in never smokers 4703
Environmental respiratory hazards epigenetically reprogram macrophages to support tumor progression in lung cancer in never smokers 4703 Open
Description In recent decades, the incidence of lung cancer (LC) in never smokers (LCINS) has steadily increased, now the 5th leading cause of cancer mortality, and environmental respiratory hazards (ERHs) are implicated in LCINS etiology.…
View article: Pulmonary macrophages transcriptionally remodel lung epithelium to increase lung cancer susceptibility in response to environmental respiratory hazards in female never smokers 3790
Pulmonary macrophages transcriptionally remodel lung epithelium to increase lung cancer susceptibility in response to environmental respiratory hazards in female never smokers 3790 Open
Description For decades there has been an alarming increase in lung cancer in never smoker (LCINS) that occurs more frequently in young women. Pulmonary macrophages (pMac) play a key role in lung cancer (LC) development and are heavily inf…
View article: A Descriptive 5‐Year Analysis of the Demographics and Therapies for Patients With Immune Thrombotic Thrombocytopenic Purpura in the <scp>USA</scp>: A Multicenter Study of 390 Disease Episodes From 2017 to 2021
A Descriptive 5‐Year Analysis of the Demographics and Therapies for Patients With Immune Thrombotic Thrombocytopenic Purpura in the <span>USA</span>: A Multicenter Study of 390 Disease Episodes From 2017 to 2021 Open
Immune thrombotic thrombocytopenic purpura (iTTP) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and microvascular occlusion secondary to acquired ADAMTS13 deficiency. Contemporary data regarding iTTP treatment pr…
View article: The seasonal distribution of immune thrombotic thrombocytopenic purpura is influenced by geography: Epidemiologic findings from a multi‐center analysis of 719 disease episodes
The seasonal distribution of immune thrombotic thrombocytopenic purpura is influenced by geography: Epidemiologic findings from a multi‐center analysis of 719 disease episodes Open
Prior studies have suggested that immune thrombotic thrombocytopenic purpura (iTTP) may display seasonal variation; however, methodologic limitations and sample sizes have diminished the ability to perform a rigorous assessment. This 5‐yea…
View article: Orchestrating Resilience: How Neuropilin-2 and Macrophages Contribute to Cardiothoracic Disease
Orchestrating Resilience: How Neuropilin-2 and Macrophages Contribute to Cardiothoracic Disease Open
Immunity has evolved to balance the destructive nature of inflammation with wound healing to overcome trauma, infection, environmental insults, and rogue malignant cells. The inflammatory response is marked by overlapping phases of initiat…
View article: E-129 Trends in demographic and geographic disparities of stroke-related mortality in older adults in the United States from 1999 to 2020
E-129 Trends in demographic and geographic disparities of stroke-related mortality in older adults in the United States from 1999 to 2020 Open
Stroke is a leading cause of mortality and morbidity in the United States. Many risk factors are controversial, and their relative importance is not fully understood. Elucidating the association between demographic and geographic disparit…
View article: Supplementary Materials and Methods from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma
Supplementary Materials and Methods from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma Open
PDF file - 106K
View article: Supplementary Materials and Methods from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma
Supplementary Materials and Methods from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma Open
PDF file - 106K
View article: Data from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma
Data from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma Open
Human malignant mesothelioma is an aggressive and highly lethal cancer that is believed to be caused by chronic exposure to asbestos and erionite. Prognosis for this cancer is generally poor because of late-stage diagnosis and resistance t…
View article: Data from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma
Data from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma Open
Human malignant mesothelioma is an aggressive and highly lethal cancer that is believed to be caused by chronic exposure to asbestos and erionite. Prognosis for this cancer is generally poor because of late-stage diagnosis and resistance t…
View article: Supplementary Figures 1-10 from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma
Supplementary Figures 1-10 from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma Open
PDF file - 4.5MB, Figure S1. HMGB1 inhibitors hinder asbestos-induced HM transformation. Figure S2. Expressions of the HMGB1 receptors TLR2 and TLR4 are variable in MM cells. Figure S3. HMGB1 is a chemotactic and mitogenic factor in MM cel…
View article: Supplementary Figures 1-10 from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma
Supplementary Figures 1-10 from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma Open
PDF file - 4.5MB, Figure S1. HMGB1 inhibitors hinder asbestos-induced HM transformation. Figure S2. Expressions of the HMGB1 receptors TLR2 and TLR4 are variable in MM cells. Figure S3. HMGB1 is a chemotactic and mitogenic factor in MM cel…
View article: Isoforms of Neuropilin-2 Denote Unique Tumor-Associated Macrophages in Breast Cancer
Isoforms of Neuropilin-2 Denote Unique Tumor-Associated Macrophages in Breast Cancer Open
Tumor-associated macrophages (TAMs) exert profound influence over breast cancer progression, promoting immunosuppression, angiogenesis, and metastasis. Neuropilin-2 (NRP2), consisting of the NRP2a and NRP2b isoforms, is a co-receptor for h…
View article: 680 Isoforms of neuropilin-2 regulate distinct macrophage functions and are associated with unique tumor-associated macrophages in murine and human breast cancer
680 Isoforms of neuropilin-2 regulate distinct macrophage functions and are associated with unique tumor-associated macrophages in murine and human breast cancer Open
Background Tumor-associated macrophages (TAMs) exert profound influence over breast cancer progression, promoting immunosuppression, angiogenesis, and metastasis.1 Neuropilin-2 (NRP2), consisting of NRP2a and NRP2b isoforms, is …
View article: 112 Tumor-specific reactivity and effector function of chimeric antigen receptor engineered macrophages targeting MUC1
112 Tumor-specific reactivity and effector function of chimeric antigen receptor engineered macrophages targeting MUC1 Open
Background Chimeric antigen receptors (CAR) have demonstrated remarkable efficacy in licensing T cells for antitumor responses against hematopoietic malignancies but have had limited success against solid tumors. Macrophages, both archetyp…
View article: Experimental respiratory exposure to putative Gulf War toxins promotes persistent alveolar macrophage recruitment and pulmonary inflammation
Experimental respiratory exposure to putative Gulf War toxins promotes persistent alveolar macrophage recruitment and pulmonary inflammation Open
These findings indicate that macrophage accumulation and pulmonary inflammation induced by GWTs continue in the absence of toxin exposure and may contribute to the immunopathology of respiratory Gulf War Illness.
View article: HMGB1 Promotes Myeloid Egress and Limits Lymphatic Clearance of Malignant Pleural Effusions
HMGB1 Promotes Myeloid Egress and Limits Lymphatic Clearance of Malignant Pleural Effusions Open
Pleural effusions, when benign, are attributed to cardiac events and suffusion of fluid within the pleural space. When malignant, lymphatic obstruction by tumor and failure to absorb constitutively produced fluid is the predominant formula…
View article: Investigating the Lytic Staphylococcus aureus Bacteriophage Reservoir Amongst a South Carolina University Population: Discovery, Characterization, and Identification of a Potential Bacteriophage Treatment for Methicillin-Resistant Staphylococcus aureus
Investigating the Lytic Staphylococcus aureus Bacteriophage Reservoir Amongst a South Carolina University Population: Discovery, Characterization, and Identification of a Potential Bacteriophage Treatment for Methicillin-Resistant Staphylococcus aureus Open
Bacteriophages are viruses that only infect bacterial cells and can be used to treat antibiotic resistant bacterial infections. This study focused on the isolation and characterization of bacteriophages lytic to Staphylococcus aureus at Co…
View article: Investigating palygorskite’s role in the development of mesothelioma in southern Nevada: Insights into fiber-induced carcinogenicity
Investigating palygorskite’s role in the development of mesothelioma in southern Nevada: Insights into fiber-induced carcinogenicity Open
Similar to asbestos fibers, nonregulated mineral fibers can cause malignant mesothelioma (MM). Recently, increased proportions of women and young individuals with MM were identified in southern Nevada, suggesting that environmental exposur…
View article: p16(INK4A) expression in invasive laryngeal cancer
p16(INK4A) expression in invasive laryngeal cancer Open
View article: Sudden Development of Thrombocytopenia After Reversal of Anticoagulation for Surgery
Sudden Development of Thrombocytopenia After Reversal of Anticoagulation for Surgery Open
Herein, we report a case of post-transfusion purpura after the reversal of anticoagulation for surgical purposes in a 66-year old ethnic Asian man who was undergoing long-term warfarin therapy for antiphospholipid syndrome. The patient exp…
View article: Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s
Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s Open
We recently discovered an inherited cancer syndrome caused by BRCA1-Associated Protein 1 (BAP1) germline mutations, with high incidence of mesothelioma, uveal melanoma and other cancers and very high penetrance by age 55. To identify famil…
View article: Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma
Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma Open
View article: Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression
Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression Open
View article: High Incidence of Somatic BAP1 Alterations in Sporadic Malignant Mesothelioma
High Incidence of Somatic BAP1 Alterations in Sporadic Malignant Mesothelioma Open