Amy Scott-Thomas
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View article: Gut Microbiota and Liver Dysfunction in Sepsis: The Role of Inflammatory Mediators and Therapeutic Approaches
Gut Microbiota and Liver Dysfunction in Sepsis: The Role of Inflammatory Mediators and Therapeutic Approaches Open
Sepsis is a life-threatening complication caused by an uncontrolled immune response to infection that can lead to multi-organ dysfunction, including liver injury. Recent research has shown the critical role of gut microbiota in sepsis path…
View article: Novel Monoclonal Antibodies 1D2 and 4E4 Against Aspergillus Glycoprotein Antigens Detect Early Invasive Aspergillosis in Mice
Novel Monoclonal Antibodies 1D2 and 4E4 Against Aspergillus Glycoprotein Antigens Detect Early Invasive Aspergillosis in Mice Open
Due to the high morbidity and mortality rates of invasive aspergillosis (IA) and the importance of early IA detection for successful treatment and subsequent outcome, this study aimed to determine a time course of detectable antigen in a m…
View article: The inhibitory effect of copper, zinc, and manganese on <i>Legionella longbeachae</i> in potting mix leachate
The inhibitory effect of copper, zinc, and manganese on <i>Legionella longbeachae</i> in potting mix leachate Open
Legionella longbeachae is the leading cause of Legionnaires’ disease (LD) in Australasia and has been linked to exposure to compost and potting soils. Adding antimicrobial metal ions such as copper (Cu2+), zinc (Zn2+), and manganese (Mn2+)…
View article: Low Vitamin C Concentrations in Patients with Community-Acquired Pneumonia Resolved with Pragmatic Administration of Intravenous and Oral Vitamin C
Low Vitamin C Concentrations in Patients with Community-Acquired Pneumonia Resolved with Pragmatic Administration of Intravenous and Oral Vitamin C Open
Community-acquired pneumonia (CAP) is characterized by elevated markers of inflammation and oxidative stress and depleted circulating concentrations of the antioxidant nutrient vitamin C. A feasibility trial of intravenous and oral vitamin…
View article: Adjunctive intravenous then oral vitamin C for moderate and severe community-acquired pneumonia in hospitalized adults: feasibility of randomized controlled trial
Adjunctive intravenous then oral vitamin C for moderate and severe community-acquired pneumonia in hospitalized adults: feasibility of randomized controlled trial Open
Patients hospitalised with community acquired pneumonia (CAP) have low peripheral blood vitamin C concentrations and limited antioxidant capacity. The feasibility of a trial of vitamin C supplementation to improve patient outcomes was asse…
View article: The inhibitory effect of copper, zinc, and manganese on <i>Legionella longbeachae</i> and other <i>Legionella</i> spp. <i>in vitro</i>
The inhibitory effect of copper, zinc, and manganese on <i>Legionella longbeachae</i> and other <i>Legionella</i> spp. <i>in vitro</i> Open
Legionella longbeachae is an important cause of Legionnaires’ disease in Australasia and is associated with exposure to potting soils. Our aim was to identify ways to reduce the load of L. longbeachae in potting soils. Inductively-coupled …
View article: A Novel Monoclonal Antibody 1D2 That Broadly Inhibits Clinically Important Aspergillus Species
A Novel Monoclonal Antibody 1D2 That Broadly Inhibits Clinically Important Aspergillus Species Open
Aspergillus fumigatus is a ubiquitous airborne fungus, is the predominant cause (>90%) of invasive aspergillosis (IA) in immunosuppressed patients and has a high mortality. New approaches to prevention and treatment are needed because of t…
View article: Hydrogen Sulfide and Substance P Levels in Patients with Escherichia coli and Klebsiella pneumoniae Bacteraemia
Hydrogen Sulfide and Substance P Levels in Patients with Escherichia coli and Klebsiella pneumoniae Bacteraemia Open
Hydrogen sulfide (H2S) and substance P (SP) are known from animal models and in vitro studies as proinflammatory mediators. In this study, peripheral blood concentrations of H2S and SP were measured in patients with Escherichia coli or Kle…
View article: Monoclonal Antibodies and Invasive Aspergillosis: Diagnostic and Therapeutic Perspectives
Monoclonal Antibodies and Invasive Aspergillosis: Diagnostic and Therapeutic Perspectives Open
Invasive aspergillosis (IA) is a life-threatening fungal disease that causes high morbidity and mortality in immunosuppressed patients. Early and accurate diagnosis and treatment of IA remain challenging. Given the broad range of non-speci…
View article: Two Monoclonal Antibodies That Specifically Recognize Aspergillus Cell Wall Antigens and Can Detect Circulating Antigens in Infected Mice
Two Monoclonal Antibodies That Specifically Recognize Aspergillus Cell Wall Antigens and Can Detect Circulating Antigens in Infected Mice Open
Invasive aspergillosis (IA) is a life-threatening disease mainly caused by Aspergillus fumigatus and Aspergillus flavus. Early diagnosis of this condition is crucial for patient treatment and survival. As current diagnostic techniques for …
View article: Presence of Legionella Longbeachae in Pine but not Composted Green Waste Used in Manufacture of Potting Soils in New Zealand
Presence of Legionella Longbeachae in Pine but not Composted Green Waste Used in Manufacture of Potting Soils in New Zealand Open
In this research we compared the proportion of samples taken at different stages in the manufacturing process of potting soils that were qPCR positive for Legionella longbeachae. This included samples of composted feed stock, mixing sites …
View article: Legionellosis Caused by Non-Legionella pneumophila Species, with a Focus on Legionella longbeachae
Legionellosis Caused by Non-Legionella pneumophila Species, with a Focus on Legionella longbeachae Open
Although known as causes of community-acquired pneumonia and Pontiac fever, the global burden of infection caused by Legionella species other than Legionella pneumophila is under-recognised. Non-L. pneumophila legionellae have a worldwide …
View article: Pine Species Provide a Niche for <i>Legionella Longbeachae</i>
Pine Species Provide a Niche for <i>Legionella Longbeachae</i> Open
Legionella longbeachae is the commonest cause of Legionnaires' disease (LD) nationwide in New Zealand (NZ). Most cases occur in spring and summer (October - January) and are associated with the use of commercial potting mix, which usually …
View article: Enhancement of Culture of Legionella longbeachae from Respiratory Samples by Use of Immunomagnetic Separation and Antimicrobial Decontamination
Enhancement of Culture of Legionella longbeachae from Respiratory Samples by Use of Immunomagnetic Separation and Antimicrobial Decontamination Open
Legionella longbeachae is the commonest Legionella species identified in patients with community-acquired pneumonia in New Zealand. Isolation of the organism on culture is the gold standard for the diagnosis of Legionnaires disease, but it…