Anoop Shah
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View article: Circulating cardiovascular biomarkers in motion: redefining cardiovascular risk with dynamic prediction
Circulating cardiovascular biomarkers in motion: redefining cardiovascular risk with dynamic prediction Open
Current approaches to estimate cardiovascular risk for primary prevention of cardiovascular disease (CVD) are suboptimal and novel strategies that optimize and personalize risk predictions are needed. In this review, we provide an overview…
View article: Ethnic differences in the comparative effectiveness of second‐line type 2 diabetes medications in preventing cardiovascular disease
Ethnic differences in the comparative effectiveness of second‐line type 2 diabetes medications in preventing cardiovascular disease Open
Aim To investigate ethnic differences in the comparative effectiveness of sulfonylureas (SU), dipeptidyl peptidase‐4 inhibitors (DPP4i) and sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) on cardiovascular outcomes. Materials and Method…
View article: Burden of cardiovascular diseases in England (2020–24): a national cohort using electronic health records data
Burden of cardiovascular diseases in England (2020–24): a national cohort using electronic health records data Open
British Heart Foundation Data Science Centre (Health Data Research UK).
View article: Neutrophil‐to‐lymphocyte ratio for risk stratification in acute myocarditis across the left ventricular ejection fraction spectrum
Neutrophil‐to‐lymphocyte ratio for risk stratification in acute myocarditis across the left ventricular ejection fraction spectrum Open
Aims Acute myocarditis (AM) is a heterogeneous clinical condition. Several classification models have been proposed to predict adverse clinical outcomes, but risk stratification remains challenging, particularly for patients presenting wit…
View article: Identifying plausible ranges for differential vaccine efficacy across high- and low-income settings: A Systematic Review, Descriptive Meta-Analysis, and illustrative evidence analysis.
Identifying plausible ranges for differential vaccine efficacy across high- and low-income settings: A Systematic Review, Descriptive Meta-Analysis, and illustrative evidence analysis. Open
Background Randomized clinical trials provide the highest standard of evidence about vaccine efficacy. Modelling exercises such as in evidence synthesis and health economic models where efficacy estimates are combined with other data to ob…
View article: B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>-Catalyzed Coupling of <i>N</i>-Alkyl Arylamines and Alkenes for the Synthesis of Tetrahydroquinolines
B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>-Catalyzed Coupling of <i>N</i>-Alkyl Arylamines and Alkenes for the Synthesis of Tetrahydroquinolines Open
Tetrahydroquinolines are featured in molecules with wide ranging properties, including those with biological activity and materials applications. This report demonstrates that widely accessible N-alkyl arylamines can be directly coupled wi…
View article: Association of Pre Pregnancy Body Mass Index and Gestational Weight Gain on Pregnancy Outcomes in Women with Gestational Diabetes: A Retrospective Observational Study
Association of Pre Pregnancy Body Mass Index and Gestational Weight Gain on Pregnancy Outcomes in Women with Gestational Diabetes: A Retrospective Observational Study Open
Introduction: The incidence of obesity and gestational diabetes is increasing globally. Gestational diabetes and obesity are known to be independently associated with adverse perinatal outcomes. Gaining excess weight in pregnancy, especial…
View article: Evaluation and treatment of post-renal transplant cytomegalovirus disease in children
Evaluation and treatment of post-renal transplant cytomegalovirus disease in children Open
Cytomegalovirus (CMV) infection typically presents as viremia, a clinical syndrome, or tissue-invasive disease. Identifying risk factors and conducting initial blood investigations, followed by invasive tests when appropriate, are crucial …
View article: Hypertension in Sub-Saharan Africa: Burden, Barriers and Priorities for Improving Treatment Outcomes
Hypertension in Sub-Saharan Africa: Burden, Barriers and Priorities for Improving Treatment Outcomes Open
The burden of hypertension is rising rapidly in sub-Saharan Africa (SSA), posing significant health challenges and economic costs that hinder national development. Despite being well-studied in clinical medicine, the detection, treatment, …
View article: 277 Advancing Surgical Education with a Cost-Efficient Toe Amputation Simulation Model: A Cohort Study
277 Advancing Surgical Education with a Cost-Efficient Toe Amputation Simulation Model: A Cohort Study Open
Introduction Undergraduate amputation education is underrepresented, limiting exposure to training. Porcine simulation models, known for their anatomical similarity to humans and cost-efficiency, have gained popularity in surgical educatio…
View article: Interobserver Variability in Cardiovascular FDG PET/CT Analysis in Large Vessel Vasculitis
Interobserver Variability in Cardiovascular FDG PET/CT Analysis in Large Vessel Vasculitis Open
Introduction: PET/CT has a synergistic value for optimal diagnosis, disease activity monitoring, and evaluation of damage progression in large vessel vasculitis. The use of standardized uptake values (SUV) as a measurement of relative tiss…
View article: Implementation strategies to improve outcomes in patients with established cardiovascular disease in sub-Saharan Africa: A systematic review
Implementation strategies to improve outcomes in patients with established cardiovascular disease in sub-Saharan Africa: A systematic review Open
Sub-Saharan Africa (SSA) is experiencing an epidemic of cardiovascular disease (CVD). Despite numerous evidence-based therapies and management guidelines for patients with acute or established CVD, significant gaps persist in their impleme…
View article: Machine learning to optimize use of natriuretic peptides in the diagnosis of acute heart failure
Machine learning to optimize use of natriuretic peptides in the diagnosis of acute heart failure Open
Aims B-type natriuretic peptide (BNP) and mid-regional pro-atrial natriuretic peptide (MR-proANP) testing are guideline-recommended to aid in the diagnosis of acute heart failure. Nevertheless, the diagnostic performance of these biomarker…
View article: Ashwagandha ( <i>Withania somnifera (L.) Dunal</i> ) for promoting recovery in long covid: protocol for a randomised placebo-controlled clinical trial (APRIL Trial)
Ashwagandha ( <i>Withania somnifera (L.) Dunal</i> ) for promoting recovery in long covid: protocol for a randomised placebo-controlled clinical trial (APRIL Trial) Open
Background Long covid describes a syndrome of persistent symptoms following COVID-19 and is responsible for substantial healthcare and economic burden. Currently, no effective treatments have been established. Ashwagandha ( Withania somnif…
View article: Ethnic variations in neutrophil count as predictors of prognosis following acute myocardial infarction
Ethnic variations in neutrophil count as predictors of prognosis following acute myocardial infarction Open
We report ethnicity-specific leucocyte dynamics after AMI. Furthermore, neutrophil count is associated with a disproportionate risk in ethnic minority compared with white individuals. Understanding post-AMI inflammation and its interaction…
View article: Arterial Stiffness is Related to Diabetes-Associated Microvascular Complications: the SEARCH for Diabetes in Youth Study
Arterial Stiffness is Related to Diabetes-Associated Microvascular Complications: the SEARCH for Diabetes in Youth Study Open
Objective: To assess the relationship between arterial stiffness, an early marker of macrovascular cardiovascular disease, and microvascular complications in adolescents and young adults with youth-onset diabetes. Research Design and Metho…
View article: Arterial Stiffness is Related to Diabetes-Associated Microvascular Complications: the SEARCH for Diabetes in Youth Study
Arterial Stiffness is Related to Diabetes-Associated Microvascular Complications: the SEARCH for Diabetes in Youth Study Open
Objective: To assess the relationship between arterial stiffness, an early marker of macrovascular cardiovascular disease, and microvascular complications in adolescents and young adults with youth-onset diabetes. Research Design and Metho…
View article: Tissue Doppler echocardiography predicts long-term cardiovascular mortality: the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) legacy 20-year follow-up study
Tissue Doppler echocardiography predicts long-term cardiovascular mortality: the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) legacy 20-year follow-up study Open
Background Left ventricular diastolic function as assessed by tissue Doppler echocardiography predicts cardiovascular event rates at 4 years of follow-up in patients with hypertension. Our aim was to evaluate whether this extends to predic…
View article: Artificial Intelligence Methods to Detect Heart Failure with Preserved Ejection Fraction (AIM-HFpEF) within Electronic Health Records: An equitable disease prediction model
Artificial Intelligence Methods to Detect Heart Failure with Preserved Ejection Fraction (AIM-HFpEF) within Electronic Health Records: An equitable disease prediction model Open
Background and aims Heart Failure with Preserved Ejection Fraction (HFpEF) accounts for approximately half of all heart failure cases, with high levels of morbidity and mortality. However, most cases of HFpEF are undiagnosed as conventiona…
View article: Imaging and Circulating Biomarker-Defined Cardiac Pathology in Pulmonary Tuberculosis: A Systematic Review
Imaging and Circulating Biomarker-Defined Cardiac Pathology in Pulmonary Tuberculosis: A Systematic Review Open
Background: Pulmonary tuberculosis (PTB) is associated with increased cardiovascular disease (CVD) mortality. However, underlying pathophysiological mechanisms are poorly understood. This systematic review aims to synthesize the evidence o…