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View article: Human Coronavirus-229E Hijacks Key Host-Cell RNA-Processing Complexes for Replication
Human Coronavirus-229E Hijacks Key Host-Cell RNA-Processing Complexes for Replication Open
The recent rise in zoonotic coronavirus outbreaks underscores the urgency to understand virus-host interactions to develop potent antiviral therapeutics. Systems biology approaches, particularly proteomics, have been invaluable in providin…
View article: Correction: Proteome-wide characterization of PTMs reveals host cell responses to viral infection and identifies putative antiviral drug targets
Correction: Proteome-wide characterization of PTMs reveals host cell responses to viral infection and identifies putative antiviral drug targets Open
[This corrects the article DOI: 10.3389/fimmu.2025.1587106.].
View article: Harnessing Nanobodies for Precision Targeting of Proteoforms: Opportunities and Challenges in Therapeutics and Diagnostics
Harnessing Nanobodies for Precision Targeting of Proteoforms: Opportunities and Challenges in Therapeutics and Diagnostics Open
Proteoforms are biologically distinct yet structurally similar proteins that play key roles in driving disease progression but are rarely accounted for in the development of therapeutics and diagnostics. Nanobodies (Nbs) have emerged as a …
View article: ProteoMeter: A pipeline for integrating multi-PTM and limited proteolysis data to reveal modification-structure coupling at the residue level
ProteoMeter: A pipeline for integrating multi-PTM and limited proteolysis data to reveal modification-structure coupling at the residue level Open
Systemic perturbations trigger extensive changes across the proteome–altering protein abundance, post-translational modifications (PTMs), conformational states, and complex assembly. Interpreting these effects demands computational pipelin…
View article: Proteome-wide characterization of PTMs reveals host cell responses to viral infection and identifies putative antiviral drug targets
Proteome-wide characterization of PTMs reveals host cell responses to viral infection and identifies putative antiviral drug targets Open
Post-translational modifications (PTMs) are biochemical modifications that can significantly alter protein structure, function, stability, localization, and interactions with other molecules, thereby activating or inactivating intracellula…
View article: Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity
Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity Open
Coronaviruses (CoV) emerge suddenly from animal reservoirs to cause novel diseases in new hosts. Discovered in 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in camels in the Middle East and is continually cau…
View article: Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity
Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity Open
Coronaviruses (CoV) emerge suddenly from animal reservoirs to cause novel diseases in new hosts. Discovered in 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in camels in the Middle East and is continually cau…
View article: Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East Respiratory Syndrome coronavirus disease severity
Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East Respiratory Syndrome coronavirus disease severity Open
Coronaviruses (CoV) emerge suddenly from animal reservoirs to cause novel diseases in new hosts. Discovered in 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in camels in the Middle East and is continually causing…
View article: Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals
Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals Open
Host kinases play essential roles in the host cell cycle, innate immune signaling, the stress response to viral infection, and inflammation. Previous work has demonstrated that coronaviruses specifically target kinase cascades to subvert h…
View article: Charting the Impact of Maternal Antibodies and Repeat Exposures on Sapovirus Immunity in Early Childhood From a Nicaraguan Birth Cohort
Charting the Impact of Maternal Antibodies and Repeat Exposures on Sapovirus Immunity in Early Childhood From a Nicaraguan Birth Cohort Open
Background Sapovirus is an important cause of acute gastroenteritis in childhood. While vaccines against sapovirus may reduce gastroenteritis burden, a major challenge to their development is a lack of information about natural immunity. M…
View article: Abstract 2357 Generation of target specific nanobodies
Abstract 2357 Generation of target specific nanobodies Open
Nanobodies (Nb) are single chain antibodies that bind available protein epitopes with remarkable specificity making them valuable tools for molecular and structural biology studies. The goal of this work is to identify target specific nano…
View article: Abstract 2416 HCoV-229E infected lung cells reveal key molecular targets using structural proteomic analysis
Abstract 2416 HCoV-229E infected lung cells reveal key molecular targets using structural proteomic analysis Open
The emergence of novel viruses from zoonotic reservoirs are on the rise which can lead to outbreaks in humans that severely impact societal functions and the global economy. Indeed, the recent SARS-CoV 2 pandemic exposed vulnerabilities an…