Amy Treece
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View article: Single-Cell RNA Sequencing of Ewing Sarcoma Tumors Demonstrates Transcriptional Heterogeneity and Clonal Evolution
Single-Cell RNA Sequencing of Ewing Sarcoma Tumors Demonstrates Transcriptional Heterogeneity and Clonal Evolution Open
Purpose: Ewing sarcoma is the second most common bone cancer in children, accounting for 2% of pediatric cancer diagnoses. Patients who present with metastatic disease at the time of diagnosis have a dismal prognosis compared with the >…
View article: Data from Pediatric Chordoma: A Tale of Two Genomes
Data from Pediatric Chordoma: A Tale of Two Genomes Open
Little is known about the genomic alterations in chordoma, with the exception of loss of SMARCB1, a core member of the SWI/SNF complex, in poorly differentiated chordomas. A TBXT duplication and rs2305089 polymorphism, located at 6q27, are…
View article: Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes Open
Rare nucleic variants of adult chordomas in COSMIC Cancer Census Genes, extracted from the original study, and lifted over from GRCh37 build to GRCh38 build.
View article: Supplementary Table 4 from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Table 4 from Pediatric Chordoma: A Tale of Two Genomes Open
List of rare ARID1B variants identified in the skull-base chordoma cohort.
View article: Supplementary Table 1 from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Table 1 from Pediatric Chordoma: A Tale of Two Genomes Open
Pediatric chordoma cohort counts of rare nonsynonymous variants determined from somatic exome sequencing in COSMIC Cancer Census Genes, broken down by variant class (VEP).
View article: Supplementary Table 2 from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Table 2 from Pediatric Chordoma: A Tale of Two Genomes Open
Allele frequency of mtDNA variants in the skull base chordoma cohort across multiple samples. Comparisons are broken down by sample number and by variant class.
View article: Supplementary Table 3 from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Table 3 from Pediatric Chordoma: A Tale of Two Genomes Open
ARID1B as the top gene of interest in the pediatric chordoma cohort with significantly high dn/ds ratio.
View article: Supplementary Table 1 from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Table 1 from Pediatric Chordoma: A Tale of Two Genomes Open
Pediatric chordoma cohort counts of rare nonsynonymous variants determined from somatic exome sequencing in COSMIC Cancer Census Genes, broken down by variant class (VEP).
View article: Supplementary Table 2 from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Table 2 from Pediatric Chordoma: A Tale of Two Genomes Open
Allele frequency of mtDNA variants in the skull base chordoma cohort across multiple samples. Comparisons are broken down by sample number and by variant class.
View article: Data from Pediatric Chordoma: A Tale of Two Genomes
Data from Pediatric Chordoma: A Tale of Two Genomes Open
Little is known about the genomic alterations in chordoma, with the exception of loss of SMARCB1, a core member of the SWI/SNF complex, in poorly differentiated chordomas. A TBXT duplication and rs2305089 polymorphism, located at 6q27, are…
View article: Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes Open
Rare nucleic variants of adult chordomas in COSMIC Cancer Census Genes, extracted from the original study, and lifted over from GRCh37 build to GRCh38 build.
View article: Supplementary Table 3 from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Table 3 from Pediatric Chordoma: A Tale of Two Genomes Open
ARID1B as the top gene of interest in the pediatric chordoma cohort with significantly high dn/ds ratio.
View article: Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes Open
Nucleic variants of the pediatric chodromas found in the COSMIC Cancer Census Genes
View article: Supplementary Table 4 from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Table 4 from Pediatric Chordoma: A Tale of Two Genomes Open
List of rare ARID1B variants identified in the skull-base chordoma cohort.
View article: Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes Open
Rare nucleic variants of pediatric chordomas in COSMIC Cancer Census Genes
View article: Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes Open
Rare mtDNA variants of pediatric chordomas
View article: Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes Open
Rare mtDNA variants of adult chordomas
View article: Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes Open
Nucleic variants of the pediatric chodromas found in the COSMIC Cancer Census Genes
View article: Figure S1 from Pediatric Chordoma: A Tale of Two Genomes
Figure S1 from Pediatric Chordoma: A Tale of Two Genomes Open
Supplementary Figure 1. Mitochondrial gene variant hotspot analysis in the pediatric chordoma cohort based on VEP variant classifications.
View article: Figure S1 from Pediatric Chordoma: A Tale of Two Genomes
Figure S1 from Pediatric Chordoma: A Tale of Two Genomes Open
Supplementary Figure 1. Mitochondrial gene variant hotspot analysis in the pediatric chordoma cohort based on VEP variant classifications.
View article: Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes Open
Rare nucleic variants of pediatric chordomas in COSMIC Cancer Census Genes
View article: Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes Open
Rare mtDNA variants of adult chordomas
View article: Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes
Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes Open
Rare mtDNA variants of pediatric chordomas
View article: Pediatric Chordoma: A Tale of Two Genomes
Pediatric Chordoma: A Tale of Two Genomes Open
Little is known about the genomic alterations in chordoma, with the exception of loss of SMARCB1, a core member of the SWI/SNF complex, in poorly differentiated chordomas. A TBXT duplication and rs2305089 polymorphism, located at 6q27, are…
View article: Bilateral Wilms tumor with anaplasia: A report from the Children's Oncology Group Study AREN0534
Bilateral Wilms tumor with anaplasia: A report from the Children's Oncology Group Study AREN0534 Open
Introduction The purpose of this study is to examine the outcomes in children with anaplastic bilateral Wilms tumor (BWT) from study AREN0534 in order to define potential prognostic factors and areas to target in future clinical trials. Me…
View article: Characterization of transcriptional heterogeneity and novel therapeutic targets using single cell RNA-sequencing of primary and circulating Ewing sarcoma cells
Characterization of transcriptional heterogeneity and novel therapeutic targets using single cell RNA-sequencing of primary and circulating Ewing sarcoma cells Open
Ewing sarcoma is the second most common bone cancer in children, accounting for 2% of pediatric cancer diagnoses. Patients who present with metastatic disease at the time of diagnosis have a dismal prognosis, compared to the >70% 5-year su…
View article: Multi-gene measurable residual disease assessed by digital polymerase chain reaction has clinical and biological utility in acute myeloid leukemia patients receiving venetoclax/azacitidine
Multi-gene measurable residual disease assessed by digital polymerase chain reaction has clinical and biological utility in acute myeloid leukemia patients receiving venetoclax/azacitidine Open
Venetoclax with azacitidine (ven/aza) is a lower-intensity therapeutic regimen that has been shown to improve outcomes in elderly patients with acute myeloid leukemia (AML). Measurable residual disease (MRD) using flow cytometry is a valua…
View article: Children's Oncology Group's 2023 blueprint for research: Renal tumors
Children's Oncology Group's 2023 blueprint for research: Renal tumors Open
Every year, approximately 600 infants, children, and adolescents are diagnosed with renal cancer in the United States. In addition to Wilms tumor (WT), which accounts for about 80% of all pediatric renal cancers, clear cell sarcoma of the …