Explanipedia

A-024 Prognosis for Adverse Events in Suspected ACS Without MI, and Subgroups with or Without History of Incident and Previous MACE Using the Atellica IM High-Sensitivity Troponin I Assay Open

Jennifer Snyder, Sarah Bethoney, Ryan Butterfield, Richard Carter, Amy Tyler , et al. · 2025

Background Cardiac troponin (cTn) is the preferred biomarker to aid in the diagnosis of myocardial infarction (MI). This study evaluated if cTnI predicts all-cause mortality (ACM) or major adverse cardiac events (MACE) (MI, cardiac death, …

Disclosure of Adverse Events in Pediatrics: Policy Statement Open

Laura Sigman, Robert Turbow, Daniel R. Neuspiel, Julia M. Kim, Steven A. Bondi , et al. · 2025

Disclosure of adverse events has become the expectation in medicine and is widely regarded as the appropriate path when medical errors occur. Although data are limited on adverse events in pediatrics, that they occur frequently is uncontes…

Transition to Weight-Based High-Flow Nasal Cannula Use Outside of the ICU for Bronchiolitis Open

Robert J. Willer, Patrick W. Brady, Amy Tyler, Jennifer D. Treasure, Eric R. Coon · 2024

Importance Most children’s hospitals have adopted weight-based high-flow nasal cannula (HFNC) bronchiolitis protocols for use outside of the intensive care unit (ICU) setting. Whether these protocols are achieving their goal of reducing br…

BS58 Identifying older donor hearts suitable for transplantation: the use of senescence as a marker of biological age. Open

María Camacho Encina, Amy Tyler, Imogen Hardwick, Laura Booth, Rachael E. Redgrave , et al. · 2023

Introduction Due to the association of ageing with adverse myocardial remodelling and declined myocardial function, hearts from donors over 65 years of age, accounting for approximately 40% of potential adult donors, are discarded for tran…

The Current State of High-Flow Nasal Cannula Protocols at Children’s Hospitals Open

Robert J. Willer, Patrick W. Brady, Amy Tyler, Jennifer D. Treasure, Eric R. Coon · 2023

OBJECTIVES To describe the current state of non-ICU high flow nasal cannula (HFNC) protocols at children’s hospitals and explore associations between HFNC protocol type and utilization outcomes. METHODS We performed a cross-sectional study…

Methods to improve the translation of evidence-based interventions: A primer on dissemination and implementation science for occupational safety and health researchers and practitioners Open

Rebecca J. Guerin, Russell E. Glasgow, Amy Tyler, Borsika A. Rabin, Amy G. Huebschmann · 2022

Reducing PICU-to-Floor Time-to-Transfer Decision in Critically Ill Bronchiolitis Patients using Quality Improvement Methodology Open

Cristin Q. Fritz, Blake Martin, Megan Riccolo, Michelle Fennell, Elise Rolison , et al. · 2022

Introduction: Specific criteria for de-escalation from the PICU are often not included in viral bronchiolitis institutional pathways. Variability of transfer preferences can prolong PICU length of stay. We aimed to decrease the time from r…

Variation in Dexamethasone Dosing and Use Outcomes for Inpatient Croup Open

Amy Tyler, Mersine A. Bryan, Chuan Zhou, Rita Mangione‐Smith, Derek J. Williams , et al. · 2021

OBJECTIVES Evaluate the association between dexamethasone dosing and outcomes for children hospitalized with croup. METHODS This study was nested within a multisite prospective cohort study of children aged 6 months to 6 years admitted to …

Implementing Improvements: Opportunities to Integrate Quality Improvement and Implementation Science Open

Amy Tyler, Russell E. Glasgow · 2021

In hospitals, improvers and implementers use quality improvement science (QIS) and less frequently implementation research (IR) to improve health care and health outcomes. Narrowly defined quality improvement (QI) guided by QIS focuses on …

Use of Procalcitonin in a Febrile Infant Clinical Pathway and Impact on Infants Aged 29 to 60 Days Open

Kaitlin Widmer, Sarah K. Schmidt, Leigh Anne Bakel, Michael W. Cookson, Jan Leonard , et al. · 2021

OBJECTIVES: Recent evidence suggests that measuring the procalcitonin level may improve identification of low-risk febrile infants who may not need intervention. We describe outcomes after the implementation of a febrile infant clinical pa…

92 Clinical Frailty Scoring Is Crucial For the COVID-19 Era and Beyond Open

Luke A. White, Amy Tyler, A. Samji · 2021

Introduction The COVID-19 pandemic placed a new focus on provision of clinical resources. With high mortality and limited capacity; appropriate decisions to escalate to critical care were vital for just resource allocation but also to prev…

Associations Between Quality Measures and Outcomes for Children Hospitalized With Bronchiolitis Open

Mersine A. Bryan, Amy Tyler, Chuan Zhou, Derek J. Williams, David Johnson , et al. · 2020

OBJECTIVES: To use adherence to the Pediatric Respiratory Illness Measurement System (PRIMES) indicators to evaluate the strength of associations for individual indicators with length of stay (LOS) and cost for bronchiolitis. METHODS: We p…

Vaccination Status and Adherence to Quality Measures for Acute Respiratory Tract Illnesses Open

Mersine A. Bryan, Annika M. Hofstetter, Tamara D. Simon, Chuan Zhou, Derek J. Williams , et al. · 2020

OBJECTIVES: To assess the relationship between vaccination status and clinician adherence to quality measures for children with acute respiratory tract illnesses. METHODS: We conducted a multicenter prospective cohort study of children age…

Qualitative Study to Understand Pediatric Hospitalists and Emergency Medicine Physicians’ Perspectives of Clinical Pathways Open

Kimberly O’Hara, Melisa Tanverdi, Jennifer A. Reich, Douglas Scudamore, Amy Tyler , et al. · 2020

Introduction: Healthcare costs are rising, and clinical pathways (CPW) are one means to promote high-value care by standardizing care and improving outcomes without compromising cost or quality. However, providers do not always follow CPW,…

080 Assessing Sarcopenia in Patients With Heart Failure - A Retrospective Clinical Audit Open

Amy Tyler, Christine Madronio, В. Paul, Amy Joseph, Faraz Pathan · 2020

Pediatric Respiratory Illness Measurement System (PRIMES) Scores and Outcomes Open

Rita Mangione‐Smith, Chuan Zhou, Derek J. Williams, David Johnson, Chén C. Kenyon , et al. · 2019

BACKGROUND AND OBJECTIVES: The Pediatric Respiratory Illness Measurement System (PRIMES) generates condition-specific composite quality scores for asthma, bronchiolitis, croup, and pneumonia in hospital-based settings. We sought to determi…

Predictors of Symptom Rebound in Critically Ill Patients With Croup Open

Amy Tyler, Lauren Anderson, Angela Moss, Jessica Graham, Amanda F. Dempsey , et al. · 2019

OBJECTIVES: There are no data to inform the ideal length of in-hospital observation after symptom improvement or to inform the ideal dexamethasone dose in critically ill children with croup. We describe a cohort of critically ill children …

Steroid variability in pediatric inpatient asthmatics: survey on provider preferences of dexamethasone versus prednisone Open

Jillian M. Cotter, Amy Tyler, Jennifer Reese, Sonja I. Ziniel, Monica J. Federico , et al. · 2019

Objective: Our hospital's pediatric Emergency Department (ED) began using dexamethasone for treating asthma exacerbations after ED studies showed non-inferiority of dexamethasone compared to prednisone. However, providers have not r…

Interventions to Reduce Over-Utilized Tests and Treatments in Bronchiolitis Open

Amy Tyler, Paul Krack, Leigh Anne Bakel, Kimberly O’Hara, Douglas Scudamore , et al. · 2018

This multidisciplinary improvement initiative resulted in a significant reduction in use for bronchiolitis care at our institution. Our approach, which included a novel, real-time data dashboard and interventions such as individual provide…

Variation in Inpatient Croup Management and Outcomes Open

Amy Tyler, Lisa McLeod, Brenda L. Beaty, Elizabeth Juaréz-Colunga, Meghan Birkholz , et al. · 2017

BACKGROUND AND OBJECTIVES: Croup is a clinical diagnosis, and the available evidence suggests that, except in rare cases, ancillary testing, such as radiologic imaging, is not helpful. Given the paucity of inpatient-specific evidence for c…

A Quality Improvement Collaborative to Improve the Discharge Process for Hospitalized Children Open

Susan Wu, Amy Tyler, Tina Logsdon, Nicholas M. Holmes, Ara Balkian , et al. · 2016

OBJECTIVE: To assess the impact of a quality improvement collaborative on quality and efficiency of pediatric discharges. METHODS: This was a multicenter quality improvement collaborative including 11 tertiary-care freestanding children’s …

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