Amy V. Nalls
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View article: Vertical transmission of chronic wasting disease in free-ranging white-tailed deer populations
Vertical transmission of chronic wasting disease in free-ranging white-tailed deer populations Open
View article: Immunological and Pathogenic Differences of Two Experimental Bluetongue Virus Serotype Infections Evaluated in Two Disparate Host Species
Immunological and Pathogenic Differences of Two Experimental Bluetongue Virus Serotype Infections Evaluated in Two Disparate Host Species Open
Bluetongue virus (BTV) is a prevalent midge-borne pathogen that infects ruminant species worldwide. BTV infections range from asymptomatic to lethal, with mechanisms that determine the severity of infection remaining largely undefined. Alt…
View article: Temporal Characterization of Prion Shedding in Secreta of White-Tailed Deer in Longitudinal Study of Chronic Wasting Disease, United States
Temporal Characterization of Prion Shedding in Secreta of White-Tailed Deer in Longitudinal Study of Chronic Wasting Disease, United States Open
Chronic wasting disease (CWD) affects cervids in North America, Asia, and Scandinavia. CWD is unique in its efficient spread, partially because of contact with infectious prions shed in secreta. To assess temporal profiles of CWD prion she…
View article: Lack of prion transmission barrier in human PrP transgenic Drosophila
Lack of prion transmission barrier in human PrP transgenic Drosophila Open
While animal prion diseases are a threat to human health, their zoonotic potential is generally inefficient because of interspecies prion transmission barriers. New animal models are required to provide an understanding of these prion tran…
View article: Monitoring longitudinal immunological responses to bluetongue virus 17 in experimentally infected sheep
Monitoring longitudinal immunological responses to bluetongue virus 17 in experimentally infected sheep Open
View article: Genetic modulation of CWD prion propagation in cervid PrP <i>Drosophila</i>
Genetic modulation of CWD prion propagation in cervid PrP <i>Drosophila</i> Open
Chronic wasting disease is a fatal prion condition of cervids such as deer, elk, moose and reindeer. Secretion and excretion of prion infectivity from North American cervids with this condition causes environmental contamination and subseq…
View article: Poster Presentations
Poster Presentations Open
Problem: Epidemiological studies in humans implicate maternal expression of different combinations of KIRs, which are a family of cell surface receptors that tune cellular activation status, as being predictive in pregnancy complication on…
View article: Clearance of variant Creutzfeldt–Jakob disease prions <i>in vivo</i> by the Hsp70 disaggregase system
Clearance of variant Creutzfeldt–Jakob disease prions <i>in vivo</i> by the Hsp70 disaggregase system Open
The metazoan Hsp70 disaggregase protects neurons from proteotoxicity that arises from the accumulation of misfolded protein aggregates. Hsp70 and its co-chaperones disassemble and extract polypeptides from protein aggregates for refolding …
View article: Detection of Chronic Wasting Disease Prions in Fetal Tissues of Free-Ranging White-Tailed Deer
Detection of Chronic Wasting Disease Prions in Fetal Tissues of Free-Ranging White-Tailed Deer Open
The transmission of chronic wasting disease (CWD) has largely been attributed to contact with infectious prions shed in excretions (saliva, urine, feces, blood) by direct animal-to-animal exposure or indirect contact with the environment. …
View article: Characterization of subclinical ZIKV infection in immune-competent guinea pigs and mice
Characterization of subclinical ZIKV infection in immune-competent guinea pigs and mice Open
An infectious agent’s pathogenic and transmission potential is heavily influenced by early events during the asymptomatic or subclinical phase of disease. During this phase, the presence of infectious agent may be relatively low. An import…
View article: Very low oral exposure to prions of brain or saliva origin can transmit chronic wasting disease
Very low oral exposure to prions of brain or saliva origin can transmit chronic wasting disease Open
The minimum infectious dose required to induce CWD infection in cervids remains unknown, as does whether peripherally shed prions and/or multiple low dose exposures are important factors in CWD transmission. With the goal of better underst…
View article: In vitro detection of haematogenous prions in white-tailed deer orally dosed with low concentrations of chronic wasting disease
In vitro detection of haematogenous prions in white-tailed deer orally dosed with low concentrations of chronic wasting disease Open
Infectivity associated with prion disease has been demonstrated in blood throughout the course of disease, yet the ability to detect blood-borne prions by in vitro methods remains challenging. We capitalized on longitudinal pathogen…
View article: Comparison of conventional, amplification and bio-assay detection methods for a chronic wasting disease inoculum pool
Comparison of conventional, amplification and bio-assay detection methods for a chronic wasting disease inoculum pool Open
Longitudinal studies of chronic wasting disease (CWD) in the native host have provided considerable understanding of how this prion disease continues to efficiently spread among cervid species. These studies entail great cost in animal, ti…
View article: Assessment of Chronic Wasting Disease Prion Shedding in Deer Saliva with Occupancy Modeling
Assessment of Chronic Wasting Disease Prion Shedding in Deer Saliva with Occupancy Modeling Open
The detection of prions is difficult due to the peculiarity of the pathogen, which is a misfolded form of a normal protein. The specificity and sensitivity of detection methods are imperfect in complex samples, including in excreta. Here, …
View article: Infectious Prions in the Pregnancy Microenvironment of Chronic Wasting Disease-Infected Reeves' Muntjac Deer
Infectious Prions in the Pregnancy Microenvironment of Chronic Wasting Disease-Infected Reeves' Muntjac Deer Open
Ample evidence exists for the presence of infectious agents at the maternal-fetal interface, often with grave outcomes to the developing fetus (i.e., Zika virus, brucella, cytomegalovirus, and toxoplasma). While less studied, pregnancy-rel…
View article: Aspects of the husbandry and management of captive cervids
Aspects of the husbandry and management of captive cervids Open
View article: In utero transmission and tissue distribution of chronic wasting disease-associated prions in free-ranging Rocky Mountain elk
In utero transmission and tissue distribution of chronic wasting disease-associated prions in free-ranging Rocky Mountain elk Open
The presence of disease-associated prions in tissues and bodily fluids of chronic wasting disease (CWD)-infected cervids has received much investigation, yet little is known about mother-to-offspring transmission of CWD. Our previous work …
View article: Immediate and Ongoing Detection of Prions in the Blood of Hamsters and Deer following Oral, Nasal, or Blood Inoculations
Immediate and Ongoing Detection of Prions in the Blood of Hamsters and Deer following Oral, Nasal, or Blood Inoculations Open
Infectious prions traverse epithelial barriers to gain access to the circulatory system, yet the temporal parameters of transepithelial transport and persistence in the blood over time remain unknown. We used whole-blood real-time quaking-…