Amy Yu
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View article: Individual and County‐Level Social Determinants of Health and Acute Reperfusion Therapies: Get With The Guidelines‐Stroke Registry Results
Individual and County‐Level Social Determinants of Health and Acute Reperfusion Therapies: Get With The Guidelines‐Stroke Registry Results Open
Background The associations between individual‐ and county‐level social determinants of health and reperfusion therapies (thrombolysis or thrombectomy) for acute ischemic stroke have been described separately, but they are rarely studied t…
View article: Harnessing Routinely Collected Health Data for Global Monitoring of Stroke: Roadmap and Vision for INSPIRE-STROKE
Harnessing Routinely Collected Health Data for Global Monitoring of Stroke: Roadmap and Vision for INSPIRE-STROKE Open
Introduction: Sustainable and low-cost data systems for national and global surveillance of stroke are urgently needed to address the growing burden of stroke. Routinely collected health data (including registries and administrative data) …
View article: Increased risk of suicide after stroke: A population-based matched cohort study
Increased risk of suicide after stroke: A population-based matched cohort study Open
Background and Objectives: We examined the timing of suicide after stroke, the sociodemographic factors associated with the risk of suicide, and whether major depression modified the stroke–suicide association. Methods: We conducted a popu…
View article: Clinical Decision-Making and Use of Clinical Decision Support When Clinicians are Fatigued in an Emergency Department: A Qualitative Study
Clinical Decision-Making and Use of Clinical Decision Support When Clinicians are Fatigued in an Emergency Department: A Qualitative Study Open
Clinicians' occupational fatigue can lead to suboptimal decisions that do not align with evidence-based guidelines or patient needs. Examining the effects of occupational fatigue on (1) clinical decision making and (2) the use of clinical …
View article: Female participation in Canadian stroke rehabilitation trials: Comparing trial participants to the inpatient rehabilitation population
Female participation in Canadian stroke rehabilitation trials: Comparing trial participants to the inpatient rehabilitation population Open
Females enrolled in stroke rehabilitation trials are underrepresented compared to inpatient rehabilitation. Trial eligibility criteria may result in the disproportionate exclusion of females compared to males.
View article: Intraosseous Versus Intravenous Vascular Access in Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Intraosseous Versus Intravenous Vascular Access in Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Background. Establishing prompt vascular access facilitates resuscitation for out-of-hospital cardiac arrest (OHCA). While intraosseous access may decrease the time to vascular access, the impact on clinical outcomes in OHCA is unclear. Th…
View article: Stroke care in indigenous populations: A World Stroke Organization (WSO) scientific statement
Stroke care in indigenous populations: A World Stroke Organization (WSO) scientific statement Open
Background: Indigenous Peoples have been reported to experience higher rates of stroke, poorer access to high-quality acute and rehabilitation stroke services, and worse post-stroke outcomes compared to dominant cultures residing in the sa…
View article: Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial
Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial Open
Background In this subanalysis of the TEMPO‐2 (Tenecteplase Versus Standard of Care for Minor Ischaemic Stroke With Proven Occlusion) trial, a randomized clinical trial comparing tenecteplase and nonthrombolytic control in patients with mi…
View article: Correlation Between Free Thyroxine Levels and Mortality in Hypertensive Patients
Correlation Between Free Thyroxine Levels and Mortality in Hypertensive Patients Open
Objective: To study the link between free thyroxine (FT4) levels and mortality in hypertensive patients. Methods: Utilizing data from the National Health and Nutrition Examination Survey performed in the United States from 2007 to 2012. Re…
View article: Access to Endovascular Thrombectomy: Does Driving Time to Comprehensive Stroke Center Matter More Than Rurality?
Access to Endovascular Thrombectomy: Does Driving Time to Comprehensive Stroke Center Matter More Than Rurality? Open
Background: Acute stroke treatments are highly time-sensitive, with geographical disparities affecting access to care. This study examined the impact of driving distance to the nearest comprehensive stroke center (CSC) and rurality on the …
View article: Creation and Evolution of the Ontario Stroke Registry: Protocol and Two Decades of Data from a Population-Based Clinical Stroke Registry
Creation and Evolution of the Ontario Stroke Registry: Protocol and Two Decades of Data from a Population-Based Clinical Stroke Registry Open
Background: Stroke clinical registries are critical for systems planning, quality improvement, advocacy and informing policy. We describe the methodology and evolution of the Registry of the Canadian Stroke Network/Ontario Stroke Registry …
View article: Levels of Evidence Supporting Recommendations in Gastroenterology
Levels of Evidence Supporting Recommendations in Gastroenterology Open
INTRODUCTION: We aimed to analyze gastrointestinal guidelines to assess the quality of evidence and strength of recommendation. METHODS: We abstracted clinical practice guidelines and guidance statements from 4 American gastroenterology so…
View article: High-Throughput Drug Screening in Chondrosarcoma Cells Identifies Effective Antineoplastic Agents Independent of IDH Mutation
High-Throughput Drug Screening in Chondrosarcoma Cells Identifies Effective Antineoplastic Agents Independent of IDH Mutation Open
The term chondrosarcoma refers to a rare and heterogeneous group of malignant cartilaginous tumors that are typically resistant to chemotherapy and radiotherapy. Metastatic chondrosarcoma has a poor prognosis, and effective systemic therap…
View article: Humans are resource-rational predictors in a sequence learning task
Humans are resource-rational predictors in a sequence learning task Open
Organisms can solve complex tasks despite having limited cognitive resources when those resources are used optimally. Doing so optimally makes an organism “resource-rational”. In this paper, we show for the first time that humans are resou…
View article: Estrogen receptor alpha (ERα) regulates PARN-mediated nuclear deadenylation and gene expression in breast cancer cells
Estrogen receptor alpha (ERα) regulates PARN-mediated nuclear deadenylation and gene expression in breast cancer cells Open
The estrogen signalling pathway is highly dynamic and primarily mediated by estrogen receptors (ERs) that transcriptionally regulate the expression of target genes. While transcriptional functions of ERs have been widely studied, their rol…
View article: Using Multilevel Models and Generalized Estimating Equation Models to Account for Clustering in Neurology Clinical Research
Using Multilevel Models and Generalized Estimating Equation Models to Account for Clustering in Neurology Clinical Research Open
In clinical and health services research, clustered data (also known as data with a multilevel or hierarchical structure) are frequently encountered. For example, patients may be clustered or nested within hospitals. Understanding when dat…
View article: Association Between Neighborhood‐Level Income and the Incidence of Cardiovascular Events Varies by Immigration Status: A Population‐Based Cohort Study
Association Between Neighborhood‐Level Income and the Incidence of Cardiovascular Events Varies by Immigration Status: A Population‐Based Cohort Study Open
Background Neighborhood‐level income is inversely associated with cardiovascular events; however, it is uncertain whether this association varies with immigration status. Methods and Results We conducted a population‐based cohort study of …
View article: Beta-Amyloid Related Neurodegenerative and Neurovascular Diseases: Potential Implications for Transfusion Medicine
Beta-Amyloid Related Neurodegenerative and Neurovascular Diseases: Potential Implications for Transfusion Medicine Open
Cerebral amyloid angiopathy (CAA) is a progressive cerebrovascular and neurodegenerative disorder that is caused by the aberrant accumulation of soluble beta-amyloid isoforms in the small vessel walls of the cerebral and cerebellar cortice…
View article: Validation of the Passive Surveillance Stroke Severity score in three Canadian provinces
Validation of the Passive Surveillance Stroke Severity score in three Canadian provinces Open
ObjectiveAdjusting for stroke severity is critical in stroke outcomes research. The Passive Surveillance Stroke SeVerity (PaSSV) score is an administrative data-based measure of stroke severity, initially derived in Ontario, Canada using d…
View article: Although Outpatient Care Patterns Changed During the Covid-19 Pandemic, Continuity Remained Important: A Retrospective Cohort Study
Although Outpatient Care Patterns Changed During the Covid-19 Pandemic, Continuity Remained Important: A Retrospective Cohort Study Open
Background The changes in outpatient care delivery during the COVID-19 pandemic represented a natural experiment which allows us to compare outcomes and evaluate the impact of physician-patient continuity after different types of outpatien…
View article: Secondary Stroke Prevention in People With Schizophrenia
Secondary Stroke Prevention in People With Schizophrenia Open
Background People with schizophrenia are less likely than those without to be treated for cardiovascular disease. We aimed to evaluate the association between schizophrenia and secondary preventive care after ischemic stroke. Methods and R…
View article: How Do Quantitative Tissue Imaging Outcomes in Acute Ischemic Stroke Relate to Clinical Outcomes?
How Do Quantitative Tissue Imaging Outcomes in Acute Ischemic Stroke Relate to Clinical Outcomes? Open
Background and Purpose Infarct volume and other imaging markers are increasingly used as surrogate measures for clinical outcome in acute ischemic stroke research, but how improvements in these imaging surrogates translate into better clin…
View article: A Randomized Controlled Trial of Tenecteplase Versus Standard of Care for Minor Ischemic Stroke with Proven Occlusion (TEMPO-2): Rational and design of a multicenter, randomized open-label clinical trial
A Randomized Controlled Trial of Tenecteplase Versus Standard of Care for Minor Ischemic Stroke with Proven Occlusion (TEMPO-2): Rational and design of a multicenter, randomized open-label clinical trial Open
Background: Almost half of acute ischemic stroke patients present with mild symptoms and there are large practice variations in their treatment globally. Individuals with an intracranial occlusion who present with minor stroke are at an in…