Amy Zheng
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View article: Initiation of dolutegravir vs. efavirenz on 12- and 24-month retention and viral suppression: a target trial emulation
Initiation of dolutegravir vs. efavirenz on 12- and 24-month retention and viral suppression: a target trial emulation Open
Initiation of dolutegravir led to an appreciable increase in retention and viral suppression over 24 months when compared to efavirenz. Dolutegravir may lead to increases in long-term retention.
View article: Field validation and application of the luminex triplex HIV assay to estimate HIV prevalence and HIV-1 incidence in Nigeria
Field validation and application of the luminex triplex HIV assay to estimate HIV prevalence and HIV-1 incidence in Nigeria Open
HIV cross-sectional surveys require multi-layered testing with several tests to estimate HIV prevalence and HIV-1 incidence. We evaluated the performance and accuracy of the newly developed HIV Triplex assay to diagnose HIV-1 and HIV-2 and…
View article: Changes in incarceration and tuberculosis notifications from prisons during the COVID-19 pandemic in Europe and the Americas: a time-series analysis of national surveillance data
Changes in incarceration and tuberculosis notifications from prisons during the COVID-19 pandemic in Europe and the Americas: a time-series analysis of national surveillance data Open
Canadian Institutes of Health Research, National Institutes of Health, and Oswaldo Cruz Foundation, Brazil.
View article: PHOTON-COUNTING CT-BASED TRABECULAR BONE ANALYSIS IN THE KNEE: A COMPARATIVE STUDY OF ADVANCED OSTEOARTHRITIS AND HEALTHY CONTROLS
PHOTON-COUNTING CT-BASED TRABECULAR BONE ANALYSIS IN THE KNEE: A COMPARATIVE STUDY OF ADVANCED OSTEOARTHRITIS AND HEALTHY CONTROLS Open
View article: Systematic Review and Meta-Analysis of Retention and Disengagement After Initiation on Antiretroviral Therapy in Low- and Middle-Income Countries After the Introduction of Universal Test and Treat Policies
Systematic Review and Meta-Analysis of Retention and Disengagement After Initiation on Antiretroviral Therapy in Low- and Middle-Income Countries After the Introduction of Universal Test and Treat Policies Open
Background We previously published a systematic review evaluating retention in care after antiretroviral therapy treatment initiation among adults in low- and middle-income countries. We estimated retention at 36 months to be at 74% for st…
View article: A novel method utilizing nasal positive pressure and video laryngoscopy assisted flexible bronchoscopic intubation: A case report
A novel method utilizing nasal positive pressure and video laryngoscopy assisted flexible bronchoscopic intubation: A case report Open
View article: Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients
Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients Open
We investigated changes in microbiome composition and abundance of antimicrobial resistance (AMR) genes post-antibiotic treatment in severe trauma patients. Shotgun sequencing revealed beta diversity (Bray-Curtis) differences between 16 ho…
View article: Prior Negative Biopsy, PSA Density, and Anatomic Location Impact Cancer Detection Rate of MRI-Targeted PI-RADS Index Lesions
Prior Negative Biopsy, PSA Density, and Anatomic Location Impact Cancer Detection Rate of MRI-Targeted PI-RADS Index Lesions Open
Background: MRI fusion prostate biopsy has improved the detection of clinically significant prostate cancer (CSC). Continued refinements in predicting the pre-biopsy probability of CSC are essential for optimal patient counseling. We inves…
View article: Immune Dysregulation, Inflammation in Characterizing Women with Vulvodynia, Depression, and Both
Immune Dysregulation, Inflammation in Characterizing Women with Vulvodynia, Depression, and Both Open
Background: Depression and vulvodynia are often comorbid. The onset of depression and vulvodynia may be immune and/or stress/environmentally induced. We explored whether vulvodynia, depression, or both occur in response to a …
View article: Resolvin E1 heals injured cardiomyocytes: Therapeutic implications and H-FABP as a readout for cardiovascular disease & systemic inflammation
Resolvin E1 heals injured cardiomyocytes: Therapeutic implications and H-FABP as a readout for cardiovascular disease & systemic inflammation Open
View article: Training Program Factors Most Important to Women When Selecting an Otolaryngology Residency
Training Program Factors Most Important to Women When Selecting an Otolaryngology Residency Open
Objectives The aim of the study was to determine factors that female resident physicians find most influential when choosing an otolaryngology residency program. Methods A three‐part survey was sent to current female otolaryngology residen…
View article: Correction: Evaluation of bleeding events in patients receiving acalabrutinib therapy
Correction: Evaluation of bleeding events in patients receiving acalabrutinib therapy Open
View article: A Public Health Critical Race Praxis Informed Congestive Heart Failure Quality Improvement Initiative on Inpatient General Medicine
A Public Health Critical Race Praxis Informed Congestive Heart Failure Quality Improvement Initiative on Inpatient General Medicine Open
View article: Does engagement in HIV care affect screening, diagnosis, and control of noncommunicable diseases in sub-Saharan Africa? A systematic review and meta-analysis
Does engagement in HIV care affect screening, diagnosis, and control of noncommunicable diseases in sub-Saharan Africa? A systematic review and meta-analysis Open
Objective Low- and middle-income countries are facing a growing burden of noncommunicable diseases (NCDs). Providing HIV treatment may also provide opportunities to increase access to NCD services in under-resourced environments. We sought…
View article: 27-year trends in incidence rates for testis cancer across a large statewide registry.
27-year trends in incidence rates for testis cancer across a large statewide registry. Open
Although TC is rare, incidence is rising. Rates of TC in Pennsylvania almost doubled over the past two decades. Fortunately, this rising trend is primarily attributed to increases in local and regional disease. Counties with higher inciden…
View article: Patients’ Perspectives on Emergency Department COVID-19 Vaccination and Vaccination Messaging Through Randomized Vignettes
Patients’ Perspectives on Emergency Department COVID-19 Vaccination and Vaccination Messaging Through Randomized Vignettes Open
Objectives: Emergency departments (EDs) could play an important role in the COVID-19 pandemic response by reaching patients who would otherwise not seek vaccination in the community. Prior to expanding COVID-19 vaccination to the acute car…
View article: Development of a Bead-Based Multiplex Assay for Use in Multianalyte Screening and Surveillance of HIV, Viral Hepatitis, Syphilis, and Herpes
Development of a Bead-Based Multiplex Assay for Use in Multianalyte Screening and Surveillance of HIV, Viral Hepatitis, Syphilis, and Herpes Open
Diagnostic assays that can simultaneously determine the presence of infection with multiple pathogens are key for diagnosis and surveillance. Current multiplex diagnostic assays are complex and often have limited availability.
View article: The Exercise-induced Improvement in Insulin-stimulated Glucose Uptake by Rat Skeletal Muscle Is Absent in Male AS160-Knockout Rats, Partially Restored by Muscle Expression of Phosphomutated AS160, and Fully Restored by Muscle Expression of Wildtype AS160
The Exercise-induced Improvement in Insulin-stimulated Glucose Uptake by Rat Skeletal Muscle Is Absent in Male AS160-Knockout Rats, Partially Restored by Muscle Expression of Phosphomutated AS160, and Fully Restored by Muscle Expression of Wildtype AS160 Open
One exercise session can elevate insulin-stimulated glucose uptake (ISGU) in skeletal muscle, but the mechanisms remain elusive. Circumstantial evidence suggests a role for Akt substrate of 160 kDa (AS160 or TBC1D4). We used genetic approa…
View article: The Exercise-induced Improvement in Insulin-stimulated Glucose Uptake by Rat Skeletal Muscle Is Absent in Male AS160-Knockout Rats, Partially Restored by Muscle Expression of Phosphomutated AS160, and Fully Restored by Muscle Expression of Wildtype AS160
The Exercise-induced Improvement in Insulin-stimulated Glucose Uptake by Rat Skeletal Muscle Is Absent in Male AS160-Knockout Rats, Partially Restored by Muscle Expression of Phosphomutated AS160, and Fully Restored by Muscle Expression of Wildtype AS160 Open
One exercise session can elevate insulin-stimulated glucose uptake (ISGU) in skeletal muscle, but the mechanisms remain elusive. Circumstantial evidence suggests a role for Akt substrate of 160 kDa (AS160 or TBC1D4). We used genetic approa…
View article: Clinical and Economic Effects of Widespread Rapid Testing to Decrease SARS-CoV-2 Transmission
Clinical and Economic Effects of Widespread Rapid Testing to Decrease SARS-CoV-2 Transmission Open
National Institutes of Health.
View article: Clinical and Economic Impact of Widespread Rapid Testing to Decrease SARS-CoV-2 Transmission
Clinical and Economic Impact of Widespread Rapid Testing to Decrease SARS-CoV-2 Transmission Open
Background The value of frequent, rapid testing to reduce community transmission of SARS-CoV-2 is poorly understood. Objective To define performance standards and predict the clinical, epidemiological, and economic outcomes of nationwide, …
View article: Asians and Asian Subgroups are Underrepresented in Medical Research Studies Published in High-Impact Generalist Journals
Asians and Asian Subgroups are Underrepresented in Medical Research Studies Published in High-Impact Generalist Journals Open
View article: Speed Versus Efficacy: Quantifying Potential Tradeoffs in COVID-19 Vaccine Deployment
Speed Versus Efficacy: Quantifying Potential Tradeoffs in COVID-19 Vaccine Deployment Open
Letters5 January 2021Speed Versus Efficacy: Quantifying Potential Tradeoffs in COVID-19 Vaccine DeploymentFREECorrection(s) for this article:CorrectionsMay 2021Correction: Quantifying Potential Tradeoffs in COVID-19 Vaccine DeploymentFREEA…
View article: Supplementary Material for: Efficiency and Clinical Outcomes of Moses Technology with Flexible Ureteroscopic Laser Lithotripsy for Treatment of Renal Calculus
Supplementary Material for: Efficiency and Clinical Outcomes of Moses Technology with Flexible Ureteroscopic Laser Lithotripsy for Treatment of Renal Calculus Open
Objective: The aim of the study was to compare the efficiency and clinical outcomes of Moses contact mode (MCM) and regular dusting mode (RDM) during flexible ureteroscopic lithotripsy (FURL) for treatment of renal calculus. …
View article: Clinical Outcomes Of A COVID-19 Vaccine: Implementation Over Efficacy
Clinical Outcomes Of A COVID-19 Vaccine: Implementation Over Efficacy Open
The global effort to develop a coronavirus disease 2019 (COVID-19) vaccine is on track to produce one or more authorized vaccines. We examine how different definitions and thresholds of vaccine efficacy, coupled with different levels of im…
View article: The Association Between Symptoms and COVID-19 Test Results Among Healthcare Workers
The Association Between Symptoms and COVID-19 Test Results Among Healthcare Workers Open
Sacks, Chana A. MD, MPH; Dougan, Michael MD, PhD; McCoy, Thomas H. Jr. MD; Zheng, Amy BA; Buonomo, Giancarlo BA; North, Crystal M. MD, MPH; Metlay, Joshua P. MD, PhD; Walensky, Rochelle P. MD, MPH Author Information
View article: Assessment of SARS-CoV-2 Screening Strategies to Permit the Safe Reopening of College Campuses in the United States
Assessment of SARS-CoV-2 Screening Strategies to Permit the Safe Reopening of College Campuses in the United States Open
In this analytic modeling study, screening every 2 days using a rapid, inexpensive, and even poorly sensitive (>70%) test, coupled with strict behavioral interventions to keep Rt less than 2.5, is estimated to maintain a controllable numbe…
View article: COVID-19 screening strategies that permit the safe re-opening of college campuses
COVID-19 screening strategies that permit the safe re-opening of college campuses Open
Importance The COVID-19 pandemic poses an existential threat to many US residential colleges: either they open their doors to students in September or they risk serious financial consequences. Objective To define SARS-CoV-2 screening perfo…
View article: Development and Validation of PREDICT-DM: A New Microsimulation Model to Project and Evaluate Complications and Treatments of Type 2 Diabetes Mellitus
Development and Validation of PREDICT-DM: A New Microsimulation Model to Project and Evaluate Complications and Treatments of Type 2 Diabetes Mellitus Open
Background: Type 2 diabetes mellitus (T2DM) affects ∼30 million people in the United States and ∼400 million people worldwide, numbers likely to increase due to the rising prevalence of obesity. We sought to design, develop, …
View article: Implementing Generalized Additive Models to Estimate the Expected Value of Sample Information in a Microsimulation Model: Results of Three Case Studies
Implementing Generalized Additive Models to Estimate the Expected Value of Sample Information in a Microsimulation Model: Results of Three Case Studies Open
Background. The expected value of sample information (EVSI) can help prioritize research but its application is hampered by computational infeasibility, especially for complex models. We investigated an approach by Strong and colleagues to…