Alice C. Wei
YOU?
Author Swipe
Genome-based classification of pancreatic acinar cell carcinoma reveals similarities to KRAS wild-type PDAC Open
Background Pancreatic acinar cell carcinoma (ACC) is a rare primary neoplasm of acinar cell origin. Histologically, it can present as pure ACC or mixed with neuroendocrine or ductal differentiation. We studied whether ACC shared genomic si…
View article: Recurrence in Patients With Lymph Node-Negative Pancreatic Neuroendocrine Tumors
Recurrence in Patients With Lymph Node-Negative Pancreatic Neuroendocrine Tumors Open
Importance Lymph node (LN) metastasis is a strong predictor of tumor recurrence following pancreatectomy for localized pancreatic neuroendocrine tumors (PanNETs). However, most patients lack LN metastasis and many tumors recur. Tools to gu…
View article: Significant new disability after major non-cardiac surgery in older adults aged 65 years and older in Canada: a multicentre prospective cohort study
Significant new disability after major non-cardiac surgery in older adults aged 65 years and older in Canada: a multicentre prospective cohort study Open
Canadian Institutes of Health Research, PSI Foundation, Ontario Ministry of Health Innovation Fund, and the Elizabeth A and Richard J Currie, OC Chair in Translational Anesthesia Research at St Michael's Hospital and the University of Toro…
View article: The Relationship Between Schizophrenia and Interoceptive Accuracy and Sensitivity: A Systematic Review and Meta-Analysis
The Relationship Between Schizophrenia and Interoceptive Accuracy and Sensitivity: A Systematic Review and Meta-Analysis Open
Interoception is the ability of a person to perceive, integrate, interpret and regulate signals from within the body. The progression of the disease in schizophrenic patients affects their interoceptive function, producing large difference…
View article: Influence of biologic sex and obesity on liver recurrence and survival in patients undergoing upfront surgery for pancreatic adenocarcinoma
Influence of biologic sex and obesity on liver recurrence and survival in patients undergoing upfront surgery for pancreatic adenocarcinoma Open
Background The influence of obesity and sex on outcomes in pancreatic adenocarcinoma (PDAC) remains unclear. The association between obesity (body mass index [BMI], ≥30) and biologic sex (male or female) for outcomes in patients with PDAC …
View article: Correction: Analysis of Short-Term Outcomes in Pancreatic Surgery with Vascular Resection from a Prospective Multicenter Global Study
Correction: Analysis of Short-Term Outcomes in Pancreatic Surgery with Vascular Resection from a Prospective Multicenter Global Study Open
In the original online version of this article, Cristina Ferrone was inadvertently omitted as the Pancreasgroup.org Chief Investigator. The original article was corrected.
View article: Clinical Utility and Prognostic Implications of Circulating Cell-Free DNA in Biliary Tract Cancer
Clinical Utility and Prognostic Implications of Circulating Cell-Free DNA in Biliary Tract Cancer Open
PURPOSE An estimated 25% of patients with biliary tract cancer (BTC) do not undergo genotyping, representing a missed opportunity for therapeutic targeting. METHODS Cell-free DNA (cfDNA) and matched tumor sample from patients with BTC were…
View article: Pembrolizumab and Olaparib (POLAR) Maintenance Therapy in Metastatic Pancreatic Cancer With or Without Homologous Repair Deficiency: A Biomarker Selected Phase II Trial
Pembrolizumab and Olaparib (POLAR) Maintenance Therapy in Metastatic Pancreatic Cancer With or Without Homologous Repair Deficiency: A Biomarker Selected Phase II Trial Open
The phase 2 POLAR trial evaluated maintenance pembrolizumab plus olaparib in 63 participants with metastatic pancreatic cancer with disease control on platinum-based chemotherapy. Participants were prospectively stratified into three cohor…
View article: Data Extraction and Curation from Radiology Reports for Pancreatic Cyst Surveillance Using Large Language Models
Data Extraction and Curation from Radiology Reports for Pancreatic Cyst Surveillance Using Large Language Models Open
BACKGROUND: Manual curation of radiographic features in pancreatic cyst registries for data abstraction and longitudinal evaluation is time-consuming and limits widespread implementation. We examined the feasibility and accuracy of using l…
View article: Clinical utility and tissue concordance of circulating tumor DNA in pancreatic ductal adenocarcinoma
Clinical utility and tissue concordance of circulating tumor DNA in pancreatic ductal adenocarcinoma Open
Background The utility of circulating tumor DNA (ctDNA) in addressing challenges of molecular tissue profiling and complementing next-generation sequencing is undefined in pancreas ductal adenocarcinoma. The objective of this study was to …
Augmenting the Future Liver Remnant Prior to Major Hepatectomy: A Review of Options on the Menu Open
The optimization of the future liver remnant (FLR) is paramount in improving outcomes for patients undergoing liver surgery, as post-hepatectomy liver failure remains a major source of postoperative morbidity and mortality. A wide collecti…
View article: Effectiveness of interactive dashboards to optimize prescribing in general practice: a systematic review
Effectiveness of interactive dashboards to optimize prescribing in general practice: a systematic review Open
Background The World Health Organisation’s Medication Without Harm campaign aims to reduce severe avoidable medication-related harm by 50%. This systematic review explored the characteristics of interventions that provide visual and longit…
View article: Histologic- and Genomic-Directed Adjuvant Therapy for Ampullary Adenocarcinoma: A Hidden Genome–Derived Analysis
Histologic- and Genomic-Directed Adjuvant Therapy for Ampullary Adenocarcinoma: A Hidden Genome–Derived Analysis Open
Background: The benefit of adjuvant chemotherapy (AC) for ampullary adenocarcinoma is unclear. The Hidden Genome model classifies prognostic subtypes with greater accuracy than standard histologic classification (intestinal [INT] vs pancre…
View article: Cognitive impairment across the schizophrenia spectrum: a comparative neuropsychological study
Cognitive impairment across the schizophrenia spectrum: a comparative neuropsychological study Open
Introduction Cognitive impairment represents a core feature of schizophrenia spectrum disorders, predating psychosis onset and persisting throughout illness progression. This cross-sectional study systematically evaluates neurocognitive fu…
View article: RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer
RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer Open
A fundamental challenge for cancer vaccines is to generate long-lived functional T cells that are specific for tumour antigens. Here we find that mRNA-lipoplex vaccines against somatic mutation-derived neoantigens may solve this challenge …
View article: Carbohydrate antigen 19-9 (CA19-9) response after induction FOLFIRINOX for locally advanced pancreatic cancer identifies patients who may benefit from surgical exploration: multicentre, observational cohort study
Carbohydrate antigen 19-9 (CA19-9) response after induction FOLFIRINOX for locally advanced pancreatic cancer identifies patients who may benefit from surgical exploration: multicentre, observational cohort study Open
Background Which patients with locally advanced pancreatic cancer may benefit from surgical exploration after induction treatment remains debated. The aim of this retrospective cohort study was to identify independent factors for overall s…
View article: Robotic Versus Open Placement of Hepatic Artery Infusion Pumps
Robotic Versus Open Placement of Hepatic Artery Infusion Pumps Open
Background A growing number of centers offer hepatic artery infusion pump (HAIP) chemotherapy for advanced liver malignancies. While small series have demonstrated feasibility of robotic HAIP placement, comparison of outcomes with open pla…
View article: Inter-rater variability for the American Society of Anesthesiologists classification in patients undergoing hepato-pancreato-biliary surgery (MILESTONE-2): international survey among surgeons and anaesthesiologists
Inter-rater variability for the American Society of Anesthesiologists classification in patients undergoing hepato-pancreato-biliary surgery (MILESTONE-2): international survey among surgeons and anaesthesiologists Open
Background Patients undergoing hepato-pancreato-biliary surgery are typically preoperatively assessed using the American Society of Anesthesiologists (ASA) classification, which is also used for case-mix adjustment when comparing centre ou…
View article: Impact of Financial Toxicity on Treatment Adherence and Quality of Life in Pancreatic Cancer
Impact of Financial Toxicity on Treatment Adherence and Quality of Life in Pancreatic Cancer Open
PURPOSE Financial toxicity (FT) is increasingly recognized as a major issue in cancer care. We evaluated the prevalence and risk factors for FT in patients with pancreatic ductal adenocarcinoma (PDAC) and FT associations with treatment adh…
View article: <i>KRAS</i> Variants Are Associated With Survival Outcomes and Genomic Alterations in Biliary Tract Cancers
<i>KRAS</i> Variants Are Associated With Survival Outcomes and Genomic Alterations in Biliary Tract Cancers Open
PURPOSE KRAS variants are associated with poor outcomes in biliary tract cancers (BTCs). This study assesses the prevalence of KRAS variants and their association with survival and recurrence in patients with intrahepatic cholangiocarcinom…
View article: Survival Outcomes and Genetic Characteristics of Resected Pancreatic Acinar Cell Carcinoma
Survival Outcomes and Genetic Characteristics of Resected Pancreatic Acinar Cell Carcinoma Open
Background Pancreatic acinar cell carcinoma (pACC) is a rare neoplasm of the exocrine pancreas. There is a dearth of information about tumor characteristics and patient outcomes. This study describes the clinical characteristics, genetic a…
View article: Adjuvant modified FOLFIRINOX for resected pancreatic adenocarcinoma: clinical insights and genomic features from a large contemporary cohort
Adjuvant modified FOLFIRINOX for resected pancreatic adenocarcinoma: clinical insights and genomic features from a large contemporary cohort Open
Background Adjuvant modified leucovorin calcium, fluorouracil, irinotecan hydrochloride, and oxaliplatin (FOLFIRINOX) is standard of care for fit individuals with resected pancreatic ductal adenocarcinoma (PDAC). Data are limited on adjuva…
View article: Long-term outcomes in patients with advanced intrahepatic cholangiocarcinoma treated with hepatic arterial infusion chemotherapy
Long-term outcomes in patients with advanced intrahepatic cholangiocarcinoma treated with hepatic arterial infusion chemotherapy Open
Background Hepatic artery infusion of chemotherapy has demonstrated disease control and suggested improvement in overall survival in intrahepatic cholangiocarcinoma. We report herein the long-term results and role of molecular alterations …
View article: Conversion Therapy to Transplant or Surgical Resection in Patients with Unresectable Hepatocellular Carcinoma Treated with Boosted Dose of Yttrium-90 Radiation Segmentectomy
Conversion Therapy to Transplant or Surgical Resection in Patients with Unresectable Hepatocellular Carcinoma Treated with Boosted Dose of Yttrium-90 Radiation Segmentectomy Open
Background/Objectives: The aim of this study was to assess the efficacy of boosted dose yttrium-90 radioembolization (TARE) as a modality for conversion therapy to transplant or surgical resection in patients with unresectable hepatocellul…