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View article: The STent Or NEphrostomy Study: A Randomised Controlled Trial Evaluating the Effectiveness of Percutaneous Nephrostomy Versus Internal Stent in Patient with Urolithiasis and an Indication for Decompression
The STent Or NEphrostomy Study: A Randomised Controlled Trial Evaluating the Effectiveness of Percutaneous Nephrostomy Versus Internal Stent in Patient with Urolithiasis and an Indication for Decompression Open
The STent Or NEphrostomy study proved a PCN to be noninferior to an internal stent in terms of the time to clinical recovery. Either option for drainage is an effective method of treatment, as long as patient-specific risk factors for tech…
View article: Recommendations for Studying <i>In Situ</i> Extracellular Vesicles From Solid Tissue
Recommendations for Studying <i>In Situ</i> Extracellular Vesicles From Solid Tissue Open
Solid tissue‐derived extracellular vesicles (ST‐EVs) are extracellular vesicles (EVs) separated directly from solid tissues of both vertebrates and invertebrates. ST‐EVs provide a physiologically relevant snapshot of tissue‐specific molecu…
View article: Follicular fluid-derived small extracellular vesicles during individual in vitro maturation improve blastocyst development
Follicular fluid-derived small extracellular vesicles during individual in vitro maturation improve blastocyst development Open
Introduction We evaluated the impact of follicular fluid-derived small extracellular vesicles (FF-sEVs) supplementation during oocyte maturation in vitro on bovine embryo outcomes, comparing group and individual culture systems. Methods Fo…
View article: Pre-formation loading of extracellular vesicles with exogenous molecules using photoporation
Pre-formation loading of extracellular vesicles with exogenous molecules using photoporation Open
Despite the natural capacity of extracellular vesicles (EVs) to encapsulate intracellular compounds and transfer these to nearby or distant recipient cells, the intentional loading of EVs with cargo molecules remains a challenging endeavor…
View article: Blood collection tube and RNA purification method recommendations for extracellular RNA transcriptome profiling
Blood collection tube and RNA purification method recommendations for extracellular RNA transcriptome profiling Open
Blood-based extracellular RNA (cell-free RNA; exRNA) biomarkers require validated sample collection, processing, and quantification procedures. No study to date has systematically tested pre-analytical variables affecting transcriptome-wid…
View article: Mapping growth and trajectory in the field of extracellular vesicles: A scientometric analysis
Mapping growth and trajectory in the field of extracellular vesicles: A scientometric analysis Open
Extracellular vesicles (EVs) are a diverse population of membrane bound particles released by cells. They play roles in a variety of diseases and biological functions, piquing the interest of researchers and industry alike. The field is of…
View article: Intact messenger RNA exists in human blood plasma and urine, and their purified macromolecular compartments
Intact messenger RNA exists in human blood plasma and urine, and their purified macromolecular compartments Open
It is generally assumed that extracellular long RNA molecules in biofluids are fragmented. Few studies have indirectly hinted at the existence of possibly functional, intact long RNA transcripts. In search for such RNA molecules, we develo…
View article: Blood collection tube and RNA purification method recommendations for extracellular RNA transcriptome profiling: A large-scale pre-analytical variable performance evaluation
Blood collection tube and RNA purification method recommendations for extracellular RNA transcriptome profiling: A large-scale pre-analytical variable performance evaluation Open
Using blood-based extracellular RNA (circulating cell-free RNA; exRNA) as a clinical biomarker requires validated procedures for sample collection and processing and RNA quantification. No study to date has systematically tested pre-analyt…
View article: Dramatic impact of blood collection tube and RNA purification method on extracellular RNA transcriptomes
Dramatic impact of blood collection tube and RNA purification method on extracellular RNA transcriptomes Open
The use of blood-based extracellular RNA (cell-free RNA; exRNA) as clinical biomarker requires the implementation of a validated procedure for sample collection, processing, and profiling. So far, no study has systematically addressed the …
View article: Cancer‐associated fibroblasts mediate resistance to neoadjuvant therapy in breast cancer
Cancer‐associated fibroblasts mediate resistance to neoadjuvant therapy in breast cancer Open
Dear Editor, We conducted a comprehensive bioinformatic analysis combined with empirical experimental evaluation, highlighting the critical role of cancer-associated fibroblasts (CAFs) in the poor outcomes of breast cancer (BC) patients un…
View article: Live Microscopy of Multicellular Spheroids with the Multimodal Near-Infrared Nanoparticles Reveals Differences in Oxygenation Gradients
Live Microscopy of Multicellular Spheroids with the Multimodal Near-Infrared Nanoparticles Reveals Differences in Oxygenation Gradients Open
Assessment of hypoxia, nutrients, metabolite gradients, and other hallmarks of the tumor microenvironment within 3D multicellular spheroid and organoid models represents a challenging analytical task. Here, we report red/near-infrared (NIR…
View article: Identification and validation of extracellular vesicle reference genes for the normalization of RT‐qPCR data
Identification and validation of extracellular vesicle reference genes for the normalization of RT‐qPCR data Open
Extracellular vesicles (EVs) contain a plethora of biomolecules, including nucleic acids, with diverse diagnostic and therapeutic application potential. Although reverse transcription‐quantitative PCR (RT‐qPCR) is the most widely applied l…
View article: Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches Open
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have ge…
View article: Live microscopy of multicellular spheroids with the multi-modal near-infrared nanoparticles reveals differences in oxygenation gradients
Live microscopy of multicellular spheroids with the multi-modal near-infrared nanoparticles reveals differences in oxygenation gradients Open
Assessment of hypoxia, nutrients, metabolite gradients, and other hallmarks of the tumor microenvironment within 3D multicellular spheroid and organoid models represents a challenging analytical task. Here, we report red/near-infrared emit…
View article: MicroRNA-146b negatively affects bovine embryo development and quality
MicroRNA-146b negatively affects bovine embryo development and quality Open
In brief MicroRNAs (miRNAs) carried in extracellular vesicles are one of the essential factors for embryo development. This study demonstrates that miRNA-146 b has negative impacts on the quality and development of bovine embryos and also …
View article: MIBlood‐EV: Minimal information to enhance the quality and reproducibility of blood extracellular vesicle research
MIBlood‐EV: Minimal information to enhance the quality and reproducibility of blood extracellular vesicle research Open
Blood is the most commonly used body fluid for extracellular vesicle (EV) research. The composition of a blood sample and its derivatives (i.e., plasma and serum) are not only donor‐dependent but also influenced by collection and preparati…
View article: Physical association of low density lipoprotein particles and extracellular vesicles unveiled by single particle analysis
Physical association of low density lipoprotein particles and extracellular vesicles unveiled by single particle analysis Open
Extracellular vesicles (EVs) in blood plasma are recognized as potential biomarkers for disease. Although blood plasma is easily obtainable, analysis of EVs at the single particle level is still challenging due to the biological complexity…
View article: Systematic compositional analysis of exosomal extracellular vesicles produced by cells undergoing apoptosis, necroptosis and ferroptosis
Systematic compositional analysis of exosomal extracellular vesicles produced by cells undergoing apoptosis, necroptosis and ferroptosis Open
Formation of extracellular vesicles (EVs) has emerged as a novel paradigm in cell‐to‐cell communication in health and disease. EVs are notably produced during cell death but it had remained unclear whether different modalities of regulated…