Jiahui An
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View article: Pellino1 is a critical regulator of HSV-1 immunity in the skin through GPR15LG 2977
Pellino1 is a critical regulator of HSV-1 immunity in the skin through GPR15LG 2977 Open
Description Infections with herpes simplex viruses (HSV) are common, painful and lifelong. Pellino1 (Peli1) is an intracellular ubiquitin ligase involved in signal transduction from TLRs and cytokine receptors. The specific role for Pellin…
View article: Spiking Neural Networks for Mental Workload Classification with a Multimodal Approach
Spiking Neural Networks for Mental Workload Classification with a Multimodal Approach Open
Accurately assessing mental workload is crucial in cognitive neuroscience, human-computer interaction, and real-time monitoring, as cognitive load fluctuations affect performance and decision-making. While Electroencephalography (EEG) base…
View article: Ultrasound spatiotemporally enables prolonged therapeutic mRNA translation in engineered bacteria for enhanced cancer immunotherapy
Ultrasound spatiotemporally enables prolonged therapeutic mRNA translation in engineered bacteria for enhanced cancer immunotherapy Open
Rationale: Engineered bacteria have recently emerged as a novel and promising strategy for cancer immunotherapy. Nonetheless, precise spatiotemporal regulation of therapeutic gene expression within these bacteria is essential to optimize t…
View article: Functional near-infrared spectroscopy short-channel regression improves cortical activation estimates of working memory load
Functional near-infrared spectroscopy short-channel regression improves cortical activation estimates of working memory load Open
SCR improves fNIRS measurement sensitivity and validity, even in tasks with minimal motor requirements.
View article: Pan-cancer analysis of acetylcholinesterase (AChE) expression by a data-driven approach: future directions of AChE in cancer neuroscience
Pan-cancer analysis of acetylcholinesterase (AChE) expression by a data-driven approach: future directions of AChE in cancer neuroscience Open
There is evidence that the expression of acetylcholinesterase (AChE) is associated with the development of certain cancers. However, there are still insufficient studies to reveal the correlation between AChE expression and cancer developm…
View article: Dioxin-like effects of an emerging contaminant 1,3,6,8-tetrabromocarbazole on the myogenic differentiation of mouse C2C12 cells
Dioxin-like effects of an emerging contaminant 1,3,6,8-tetrabromocarbazole on the myogenic differentiation of mouse C2C12 cells Open
1,3,6,8-Tetrabromocarbazole (1368-BCZ) has been proposed as an emerging environmental contaminant which has aryl hydrocarbon receptor (AhR) activating properties analogous to those of dioxins. Skeletal muscle development is a critical targ…
View article: Development of an in silico serotyping database of Vibrio harveyi by identification and comparison of O-antigen encoding loci
Development of an in silico serotyping database of Vibrio harveyi by identification and comparison of O-antigen encoding loci Open
Vibrio harveyi is an important pathogen for aquatic fish and invertebrates, that can lead to significant economic losses in the aquaculture industry. Rapid and accurate serotyping is essential for the diagnosis and epidemiological investig…
View article: High-Risk Genotypes of Human Papillomavirus at Diverse Anogenital Sites among Chinese Women: Infection Features and Potential Correlation with Cervical Intraepithelial Neoplasia
High-Risk Genotypes of Human Papillomavirus at Diverse Anogenital Sites among Chinese Women: Infection Features and Potential Correlation with Cervical Intraepithelial Neoplasia Open
Background: Both cervical cancer and cervical intraepithelial neoplasia (CIN) are associated with human papillomavirus (HPV) infection at different anogenital sites, but the infection features of high-risk (HR) HPVs at these sites and thei…
View article: Floxed Il1rl2 Locus with mCherry Reporter Element Reveals Distinct Expression Patterns of the IL-36 Receptor in Barrier Tissues
Floxed Il1rl2 Locus with mCherry Reporter Element Reveals Distinct Expression Patterns of the IL-36 Receptor in Barrier Tissues Open
IL-36 cytokines are emerging as beneficial in immunity against pathogens and cancers but can also be detrimental when dysregulated in autoimmune and autoinflammatory conditions. Interest in targeting IL-36 activity for therapeutic purposes…
View article: Pili Subunit PilA Contributes to the Cytoadhesion of <i>Glaesserella Parasuis</i> to Host Cells and Provides Immunoprotection
Pili Subunit PilA Contributes to the Cytoadhesion of <i>Glaesserella Parasuis</i> to Host Cells and Provides Immunoprotection Open
G. parasuis is one of the most prevalent bacterial infections in swine production and can lead to huge economic losses around the world. A full understanding of colonization and immunity with G. parasuis infections will be essential in dis…
View article: Severe Inflammation Caused by Coinfection of PCV2 and Glaesserella parasuis Is Associated with Pyroptosis via Noncanonical Inflammasome Pathway
Severe Inflammation Caused by Coinfection of PCV2 and Glaesserella parasuis Is Associated with Pyroptosis via Noncanonical Inflammasome Pathway Open
Coinfections of porcine circovirus type 2 (PCV2) and Glaesserella parasuis (G. parasuis) are widely existing in the swine industry worldwide. However, the mechanisms for this coinfection remain unclear. The aim of this study is to assess w…
View article: Trichostatin A increases BDNF protein expression by improving XBP-1s/ATF6/GRP78 axis in Schwann cells of diabetic peripheral neuropathy
Trichostatin A increases BDNF protein expression by improving XBP-1s/ATF6/GRP78 axis in Schwann cells of diabetic peripheral neuropathy Open
Diabetic peripheral neuropathy (DPN) is the common complication of diabetes mellitus. Histone deacetylase (HDAC) inhibitor trichostatin A (TSA) is reported to ameliorate the peripheral nerves degeneration of DPN. However, the exact mechani…
View article: ICEHpsaHPS7, a Novel Multiple Drug Resistance Integrative Conjugative Element in <i>Glaesserella parasuis</i>
ICEHpsaHPS7, a Novel Multiple Drug Resistance Integrative Conjugative Element in <i>Glaesserella parasuis</i> Open
Integrative conjugative elements (ICEs) are a kind of novel self-transmissible mobile genetic element. In this study, a novel ICE was identified in Glaesserella ( Haemophilus ) parasuis .
View article: STAT3 phosphorylation mediates high glucose—impaired cell autophagy in an HDAC1‐dependent and ‐independent manner in Schwann cells of diabetic peripheral neuropathy
STAT3 phosphorylation mediates high glucose—impaired cell autophagy in an HDAC1‐dependent and ‐independent manner in Schwann cells of diabetic peripheral neuropathy Open
Schwann cells are the main supportive cells of the peripheral nerves. Schwann cells suffer inhibition of autophagy under hyperglycemia treatment in diabetic peripheral neuropathy (DPN). However, the exact mechanism is still not fully eluci…
View article: Detection and sequencing of porcine circovirus 3 in commercially sourced laboratory mice
Detection and sequencing of porcine circovirus 3 in commercially sourced laboratory mice Open
Porcine circovirus 3 ( PCV 3), a recently discovered virus, has spread widely in pigs throughout the world. In order to investigate the possibility of mice used to study the infection of PCV 3, commercially sourced Balb/C and ICR mice were…
View article: HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372
HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372 Open
Changes in histone lysine methylation status have been observed during cancer formation. JMJD2A protein is a demethylase that is overexpressed in several tumors. Herein, our results demonstrate that JMJD2A accelerates malignant progression…
View article: Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis
Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis Open
Cancer stem cells are associated with tumor recurrence. IKK is a protein kinase that is composed of IKKα, IKKβ, IKKγ. Herein, we demonstrate that IKKα plus IKKβ promoted and IKKγ inhibited liver cancer stem cell growth in vitro and in vivo…
View article: Double mutant P53 (N340Q/L344R) promotes hepatocarcinogenesis through upregulation of Pim1 mediated by PKM2 and LncRNA CUDR
Double mutant P53 (N340Q/L344R) promotes hepatocarcinogenesis through upregulation of Pim1 mediated by PKM2 and LncRNA CUDR Open
P53 is frequently mutated in human tumors as a novel gain-of-function to promote tumor development. Although dimeric (M340Q/L344R) influences on tetramerisation on site-specific post-translational modifications of p53, it is not clear how …
View article: CUDR promotes liver cancer stem cell growth through upregulating TERT and C-Myc
CUDR promotes liver cancer stem cell growth through upregulating TERT and C-Myc Open
Cancer up-regulated drug resistant (CUDR) is a novel non-coding RNA gene. Herein, we demonstrate excessive CUDR cooperates with excessive CyclinD1 or PTEN depletion to accelerate liver cancer stem cells growth and liver stem cell malignant…
View article: miR675 upregulates long noncoding RNA H19 through activating EGR1 in human liver cancer
miR675 upregulates long noncoding RNA H19 through activating EGR1 in human liver cancer Open
microRNAs (miRNAs) are short non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miR675, embedded in H19's first exon,…
View article: LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2
LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2 Open
Long non-coding RNA HOTAIR predicts negative tumor prognosis and exhibits oncogenic activity. Herein, we demonstrate HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2. Mechanistically, HOTAIR red…