Meian He
YOU?
Author Swipe
View article: Associations of phthalates and metal(loid)s co-exposure with abdominal obesity indices in Shenzhen, China
Associations of phthalates and metal(loid)s co-exposure with abdominal obesity indices in Shenzhen, China Open
Previous studies have evaluated the obesogenic effects of phthalates or metal(loid)s individually, but the association between their co-exposure and abdominal obesity (AOB) indices, remains largely unknown. We thus aimed to investigate the…
View article: Associations between circulating multiple metals and immunoglobulin levels: A cross-sectional study
Associations between circulating multiple metals and immunoglobulin levels: A cross-sectional study Open
Our findings indicate that long-term exposure to specific metals is linked to distinct alterations in humoral immunity, particularly reductions in IgA and increases in IgG and IgE, underscoring the potential role of environmental metal exp…
View article: Bisphenol A exposure and myocardial ischemia and mitigation by L-arginine supplementation
Bisphenol A exposure and myocardial ischemia and mitigation by L-arginine supplementation Open
Among adults without a history of cardiovascular diseases (CVD), we estimated the effects of urinary bisphenol A (BPA) and plasma nitric oxide metabolites (NOx) on risks of 24-h ST-segment depression events (STDE) and T-wave inversion even…
View article: Metals exposure, biological aging and metabolic syndrome: exploring the associations and mediation effects
Metals exposure, biological aging and metabolic syndrome: exploring the associations and mediation effects Open
Metals disequilibrium is crucial in the progress of metabolic syndrome (MetS), whereas the underlying mechanism remains largely unclear. Aging is closely related with the major diseases, and recent studies show environmental exposure also …
View article: Deficiency in POLE exonuclease causes synthetic lethality in highly aneuploid cancer cells
Deficiency in POLE exonuclease causes synthetic lethality in highly aneuploid cancer cells Open
Summary Aneuploidy is a hallmark of cancer and is associated with drug resistance and poor clinical outcomes across diverse cancer types. However, no therapies have been clinically established to target highly aneuploid tumors. By analyzin…
View article: Relationship Between Aquatic Fungal Diversity in Surface Water and Environmental Factors in Yunnan Dashanbao Black-Necked Crane National Nature Reserve, China
Relationship Between Aquatic Fungal Diversity in Surface Water and Environmental Factors in Yunnan Dashanbao Black-Necked Crane National Nature Reserve, China Open
Aquatic fungi serve as core ecological engines in freshwater ecosystems, driving organic matter decomposition and energy flow to sustain environmental balance. Wetlands, with their distinct hydrological dynamics and nutrient-rich matrices,…
View article: Low and Decreasing Cholesterol Levels and Risk of All-Cause and Cause-Specific Mortality: A Prospective and Longitudinal Cohort Study
Low and Decreasing Cholesterol Levels and Risk of All-Cause and Cause-Specific Mortality: A Prospective and Longitudinal Cohort Study Open
This prospective study aimed to investigate the associations of untreated cholesterol levels and their longitudinal changes, especially low levels, with all-cause and cause-specific mortality in different populations. Participants were dra…
View article: Trends in serum levels of emerging and legacy per- and polyfluoroalkyl substances from 2008 to 2018: a longitudinal study in China
Trends in serum levels of emerging and legacy per- and polyfluoroalkyl substances from 2008 to 2018: a longitudinal study in China Open
Our study provides information on serum PFAS levels in Chinese retired workers in the Dongfeng-Tongji cohort, and highlights that the risk of exposure to novel PFCAs and PFAS alternatives deserves continued attention. For longitudinal stud…
View article: Association between organochlorine pesticides and metabolic dysfunction-associated steatotic liver disease: Findings from the Dongfeng-Tongji cohort
Association between organochlorine pesticides and metabolic dysfunction-associated steatotic liver disease: Findings from the Dongfeng-Tongji cohort Open
This longitudinal study revealed that higher levels of β-HCH and ΣDDTs were associated with increased odds of MASLD, with a positive joint effect. More attention is needed on the harmful effects of OCP co-exposure and acceleration of OCP r…
View article: Exposure to polycyclic aromatic hydrocarbons and risk of abnormal liver function: The mediating role of C-reactive protein
Exposure to polycyclic aromatic hydrocarbons and risk of abnormal liver function: The mediating role of C-reactive protein Open
Polycyclic aromatic hydrocarbons (PAHs) exposure has been suggested to be linked to abnormal liver function (ALF). However, the conclusions are inconsistent, and the underlying mechanism is still unclear. In this study, a cross-sectional d…
View article: Association between blood metal elements and lung cancer: a cross-sectional and Mendelian randomization study
Association between blood metal elements and lung cancer: a cross-sectional and Mendelian randomization study Open
Iron is inversely related to the incidence of lung cancer, with MR analysis supporting its protective role in LUAD. These findings necessitate further validation in large-scale prospective cohort studies.
View article: Value of triglyceride glucose-body mass index in predicting nonalcoholic fatty liver disease in individuals with type 2 diabetes mellitus
Value of triglyceride glucose-body mass index in predicting nonalcoholic fatty liver disease in individuals with type 2 diabetes mellitus Open
Background There is limited data on the association between TyG-BMI and NAFLD in patients with Type 2 Diabetes Mellitus (T2DM). The magnitude of risk prediction and predictive efficacy of TyG-BMI for T2DM with NAFLD remains unclear. Object…
View article: Associations between polychlorinated biphenyls and cancer risk among type 2 diabetes: The modifying effects of lifestyle
Associations between polychlorinated biphenyls and cancer risk among type 2 diabetes: The modifying effects of lifestyle Open
A growing percentage of diabetes-related deaths has been attributed to cancer, with environmental factors playing important contributions. Thus, we studied the potential relationship between endocrine disruptors polychlorinated biphenyls (…
View article: Genome-wide DNA methylation profiling in blood reveals epigenetic signature of incident acute coronary syndrome
Genome-wide DNA methylation profiling in blood reveals epigenetic signature of incident acute coronary syndrome Open
DNA methylation (DNAm) has been implicated in acute coronary syndrome (ACS), but the causality remains unclear in cross-sectional studies. Here, we conduct a prospective epigenome-wide association study of incident ACS in two Chinese cohor…
View article: Genetic predisposition to impaired beta-cell function modifies the association between serum pyrethroid levels and the risk of type 2 diabetes: A gene-environment interaction study
Genetic predisposition to impaired beta-cell function modifies the association between serum pyrethroid levels and the risk of type 2 diabetes: A gene-environment interaction study Open
Previous studies suggested that pyrethroid exposure was associated with elevated type 2 diabetes (T2D) risk, while it remains uncertain whether genetic predisposition modifies this association. A nested case-control study within the prospe…
View article: Associations of Plasma Metabolites With Risks of Incident Stroke and Its Subtypes in Chinese Adults
Associations of Plasma Metabolites With Risks of Incident Stroke and Its Subtypes in Chinese Adults Open
Background Metabolomics studies have identified various metabolic markers associated with stroke risk, yet much uncertainty persists regarding heterogeneity in these associations between different stroke subtypes. We aimed to examine metab…
View article: Polygenic Risk Score Modifies the Association of HbA1c With Hearing Loss in Middle-Aged and Older Chinese Individuals: The Dongfeng-Tongji Cohort
Polygenic Risk Score Modifies the Association of HbA1c With Hearing Loss in Middle-Aged and Older Chinese Individuals: The Dongfeng-Tongji Cohort Open
OBJECTIVE Evidence regarding the modifying effect of the polygenic risk score (PRS) on the associations between glycemic traits and hearing loss (HL) was lacking. We aimed to examine whether these associations can be influenced by genetic …
View article: Polygenic risk score modifies the association of HbA1c with hearing loss in middle-aged and older Chinese: The Dongfeng-Tongji cohort
Polygenic risk score modifies the association of HbA1c with hearing loss in middle-aged and older Chinese: The Dongfeng-Tongji cohort Open
Objective: Evidence regarding the modifying effect of polygenic risk score (PRS) on the association between glycemic traits and hearing loss (HL) was lacking. We aimed to examine whether these association can be influenced by genetic susce…
View article: Polygenic risk score modifies the association of HbA1c with hearing loss in middle-aged and older Chinese: The Dongfeng-Tongji cohort
Polygenic risk score modifies the association of HbA1c with hearing loss in middle-aged and older Chinese: The Dongfeng-Tongji cohort Open
Objective: Evidence regarding the modifying effect of polygenic risk score (PRS) on the association between glycemic traits and hearing loss (HL) was lacking. We aimed to examine whether these association can be influenced by genetic susce…
View article: Effects of multiple metals exposure on abnormal liver function: The mediating role of low-density lipoprotein cholesterol
Effects of multiple metals exposure on abnormal liver function: The mediating role of low-density lipoprotein cholesterol Open
Equilibration of metal metabolism is critical for normal liver function. Most epidemiological studies have only concentrated on the influence of limited metals. However, the single and synergistic impact of multiple-metal exposures on abno…
View article: Circulating concentrations of bile acids and prevalent chronic kidney disease among newly diagnosed type 2 diabetes: a cross-sectional study
Circulating concentrations of bile acids and prevalent chronic kidney disease among newly diagnosed type 2 diabetes: a cross-sectional study Open
Background The relationship between circulating bile acids (BAs) and kidney function among patients with type 2 diabetes is unclear. We aimed to investigate the associations of circulating concentrations of BAs, particularly individual BA …