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View article: Effects of Novel Mutations in the LEPR Gene on Litter Size in Gobi Short Tail Sheep and Sonid Sheep
Effects of Novel Mutations in the LEPR Gene on Litter Size in Gobi Short Tail Sheep and Sonid Sheep Open
Increasing the litter size in sheep is a primary objective in breeding programs, driving sustained interest in identifying candidate functional genes and molecular markers associated with fecundity. The known FecD mutation in the LEPR gene…
View article: Jinwei Sinisan Alleviates Depression-Like Behaviors in Cums Mice by Regulating Synaptic Plasticity Through Pld2 Pathway
Jinwei Sinisan Alleviates Depression-Like Behaviors in Cums Mice by Regulating Synaptic Plasticity Through Pld2 Pathway Open
View article: Unravelling the Link between Psychological Distress and Liver Disease: Insights from an Anxiety-like Rat Model and Metabolomics Analysis
Unravelling the Link between Psychological Distress and Liver Disease: Insights from an Anxiety-like Rat Model and Metabolomics Analysis Open
Psychological distress is associated with an increase in liver disease mortality. This association highlights the close relationship between psychological and physical health. The underlying mechanism of this association needs to be elucid…
View article: The Effects of Early-Life Stress on Liver Transcriptomics and the Protective Role of EPA in a Mouse Model of Early-Life-Stress-Induced Adolescent Depression
The Effects of Early-Life Stress on Liver Transcriptomics and the Protective Role of EPA in a Mouse Model of Early-Life-Stress-Induced Adolescent Depression Open
Early-life stress (ELS) was found to increase the risk of adolescent depression, and clinical evidence indicated that eicosapentaenoic acid (EPA) was decreased in patients with adolescent depression, but the underlying mechanisms are uncle…
View article: Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway
Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway Open
Hepatic fibrosis (HF) could be developed into liver cirrhosis or even hepatocellular carcinoma. Stress has an important role in the occurrence and development of various considerable diseases. However, the effect of a certain degree stress…
View article: Metabolomics revealed the anxiety-like behaviors led to liver injury through EGFR/PI3K/AKT/NF-κB pathway in rats
Metabolomics revealed the anxiety-like behaviors led to liver injury through EGFR/PI3K/AKT/NF-κB pathway in rats Open
Psychological distress is associated with increased liver disease mortality. This association highlighted the close relationship between psychological and physical health. Thus, further work to elucidated the underlying mechanism should be…
View article: Yao medicine Amydrium hainanense suppresses hepatic fibrosis by repressing hepatic stellate cell activation via STAT3 signaling
Yao medicine Amydrium hainanense suppresses hepatic fibrosis by repressing hepatic stellate cell activation via STAT3 signaling Open
Ethnopharmacological relevance: Hepatic fibrosis (HF) occurs in response to chronic liver injury and may easily develop into irreversible liver cirrhosis or even liver cancer. Amydrium hainanense water extract (AHWE) is a water-soluble com…
View article: Comparative Analysis of the Metabolites and Biological Activity of Cultivated and Wild <i>Lignosus rhinocerotis</i>
Comparative Analysis of the Metabolites and Biological Activity of Cultivated and Wild <i>Lignosus rhinocerotis</i> Open
In this paper, Lignosus rhinocerotis (Cooke) Ryvarden ( L. rhinocerotis ) cultivated in rice medium (LRR) and in sawdust medium (LRS) was harvested. Then, in terms of the LRR, LRS, and wild L. rhinocerotis (LRW), the total flavonoid conten…
View article: Integrating Network Pharmacology and Experimental Validation to Investigate the Effects and Mechanism of Astragalus Flavonoids Against Hepatic Fibrosis
Integrating Network Pharmacology and Experimental Validation to Investigate the Effects and Mechanism of Astragalus Flavonoids Against Hepatic Fibrosis Open
Hepatic fibrosis (HF) represents the excessive wound healing where an excess amount of connective tissues is formed within the liver, finally resulting in cirrhosis or even hepatocellular carcinoma (HCC). Therefore, it is significant to di…
View article: The Potential Antioxidant Activity and Characterization of Bioactive Compounds of <i>Stahlianthus involucratus</i>
The Potential Antioxidant Activity and Characterization of Bioactive Compounds of <i>Stahlianthus involucratus</i> Open
Stahlianthus involucratus ( S. involucratus ) has anti‐inflammatory, antinociceptive, and antipyretic activities; however, there are no literature reports on its antioxidant capacity. This study presents a comparative assessment of the pol…
View article: Lysosomal Acid Lipase, a Novel Biomarker for Hepatic Fibrosis
Lysosomal Acid Lipase, a Novel Biomarker for Hepatic Fibrosis Open