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View article: Effect of alirocumab on postprandial hyperlipidaemia in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled, cross‐over trial
Effect of alirocumab on postprandial hyperlipidaemia in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled, cross‐over trial Open
Aims Postprandial hyperlipidaemia (PPL), characterized by elevated triglyceride (TG) concentrations after a meal, is common in type 2 diabetes (T2D) and is often recognized as an independent cardiovascular risk factor. Here, we aimed to as…
View article: The glycoprotein GP130 governs the surface presentation of the G protein–coupled receptor APLNR
The glycoprotein GP130 governs the surface presentation of the G protein–coupled receptor APLNR Open
Glioblastoma is one of the most lethal forms of adult cancer, with a median survival of ∼15 mo. Targeting glioblastoma stem-like cells (GSCs) at the origin of tumor formation and relapse may prove beneficial. In situ, GSCs are nested withi…
View article: Serine 165 phosphorylation of SHARPIN regulates the activation of NF-κB
Serine 165 phosphorylation of SHARPIN regulates the activation of NF-κB Open
The adaptor SHARPIN composes, together with the E3 ligases HOIP and HOIL1, the linear ubiquitin chain assembly complex (LUBAC). This enzymatic complex catalyzes and stamps atypical linear ubiquitin chains onto substrates to modify their fa…
View article: Serine 165 Phosphorylation of SHARPIN regulates the Activation of NF-κB
Serine 165 Phosphorylation of SHARPIN regulates the Activation of NF-κB Open
The adaptor SHARPIN composes, together with the E3 ligases HOIP and HOIL1, the linear ubiquitin chain assembly complex. This enzymatic complex catalyzes and stamps atypical linear ubiquitin chains onto substrates to modify their fate, and …
View article: Post-translational Modifications of the CARMA1-BCL10-MALT1 Complex in Lymphocytes and Activated B-Cell Like Subtype of Diffuse Large B-Cell Lymphoma
Post-translational Modifications of the CARMA1-BCL10-MALT1 Complex in Lymphocytes and Activated B-Cell Like Subtype of Diffuse Large B-Cell Lymphoma Open
Piracy of the NF-κB transcription factors signaling pathway, to sustain its activity, is a mechanism often deployed in B-cell lymphoma to promote unlimited growth and survival. The aggressive activated B-cell like (ABC) subtype of diffuse …
View article: Inhibition of mTOR in head and neck cancer cells alters endothelial cell morphology in a paracrine fashion
Inhibition of mTOR in head and neck cancer cells alters endothelial cell morphology in a paracrine fashion Open
Head and neck squamous cell carcinoma (HNSCC) represent aggressive classes of tumors with a high mortality rate. The mammalian target of rapamycin (mTOR) pathway is instrumental in their initiation and expansion. Although results from pre‐…
View article: Assessment of new potential therapeutic targets in murine and cellular models of gastrointestinal stromal tumors
Assessment of new potential therapeutic targets in murine and cellular models of gastrointestinal stromal tumors Open
The present thesis project focused on the preclinical study of Neurotensin receptor 1 (Ntsr1), Endoglin/CD105 (Eng), Glypican 6 (Gpc6) and Sprouty homolog 4 (Spry4) as potential markers or molecular targets for future therapeutic intervent…
View article: Hyperplasia of Interstitial Cells of Cajal in Sprouty Homolog 4 Deficient Mice
Hyperplasia of Interstitial Cells of Cajal in Sprouty Homolog 4 Deficient Mice Open
Gastrointestinal stromal tumors, which are thought to derive from interstitial cells of Cajal or their precursors, often harbor an oncogenic mutation of the KIT receptor tyrosine kinase. Sprouty homolog 4, a known negative regulator of ERK…