Xiaomeng An
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View article: Kinetic Characterization and Inhibitor Screening of Pyruvate Kinase I From Babesia microti
Kinetic Characterization and Inhibitor Screening of Pyruvate Kinase I From Babesia microti Open
The apicomplexan Babesia microti is a main pathogenic parasite causing human babesiosis, which is one of the most widely distributed tick-borne diseases in humans. Pyruvate kinase (PYK) plays a central metabolic regulatory role in most liv…
View article: Erythrocyte Adhesion of Merozoite Surface Antigen 2c1 Expressed During Extracellular Stages of Babesia orientalis
Erythrocyte Adhesion of Merozoite Surface Antigen 2c1 Expressed During Extracellular Stages of Babesia orientalis Open
Babesia orientalis , a major infectious agent of water buffalo hemolytic babesiosis, is transmitted by Rhipicephalus haemaphysaloides . However, no effective vaccine is available. Essential antigens that are involved in parasite invasion o…
View article: Inhibitory Effects of Fosmidomycin Against Babesia microti in vitro
Inhibitory Effects of Fosmidomycin Against Babesia microti in vitro Open
Babesia microti, the main pathogen causing human babesiosis, has been reported to exhibit resistance to the traditional treatment of azithromycin + atovaquone and clindamycin + quinine, suggesting the necessity of developing new dru…
View article: Identifying the Naphthalene-Based Compound 3,5-Dihydroxy 2-Napthoic Acid as a Novel Lead Compound for Designing Lactate Dehydrogenase-Specific Antibabesial Drug
Identifying the Naphthalene-Based Compound 3,5-Dihydroxy 2-Napthoic Acid as a Novel Lead Compound for Designing Lactate Dehydrogenase-Specific Antibabesial Drug Open
Human babesiosis is caused by apicomplexan Babesia parasites, including Babesia microti, Babesia crassa, Babesia sp. MOI, Babesia divergens, Babesia duncani, and Babesia venatorum. Among the…
View article: Surface Antigen 1 Is a Crucial Secreted Protein That Mediates Babesia microti Invasion Into Host Cells
Surface Antigen 1 Is a Crucial Secreted Protein That Mediates Babesia microti Invasion Into Host Cells Open
Babesia microti, a tick-borne intraerythrocytic zoonotic protozoan, causes most of human babesiosis in the world, and patients usually experience intermittent fever, fatigue, and chills, followed by a combination of additional sympt…
View article: Evaluation of Babesia gibsoni GPI-anchored Protein 47 (BgGPI47-WH) as a Potential Diagnostic Antigen by Enzyme-Linked Immunosorbent Assay
Evaluation of Babesia gibsoni GPI-anchored Protein 47 (BgGPI47-WH) as a Potential Diagnostic Antigen by Enzyme-Linked Immunosorbent Assay Open
Babesia gibsoni is one of the important pathogens causing severe incurable canine babesiosis, suggesting the necessity to develop a sensitive, specific, and highly automated diagnostic method for clinical application. Surface protei…
View article: Identification and molecular characterization of a novel Babesia orientalis thrombospondin-related anonymous protein (BoTRAP1)
Identification and molecular characterization of a novel Babesia orientalis thrombospondin-related anonymous protein (BoTRAP1) Open
View article: Efficient RNA-guided base editing for disease modeling in pigs
Efficient RNA-guided base editing for disease modeling in pigs Open
View article: In vivo tunable CRISPR mediates efficient somatic mutagenesis to generate tumor models
In vivo tunable CRISPR mediates efficient somatic mutagenesis to generate tumor models Open
In vivo tunable CRISPR mediates efficient somatic mutagenesis to generate tumor models
View article: <i>piggyBac</i> mediates efficient in vivo CRISPR library screening for tumorigenesis in mice
<i>piggyBac</i> mediates efficient in vivo CRISPR library screening for tumorigenesis in mice Open
Significance Because genome-wide CRISPR/Cas9 libraries are mostly constructed in lentiviral vectors, direct in vivo screening has not been possible as a result of low efficiency in delivery. Here, we examined the piggyBac (PB) transposon a…